Objective Analysis of nitroglycerin combined with predictive nursing in the clinical application of coronary heart disease patients. Methods From January 2015 to December 2016, 200 patients with coronary heart disease were treated with angina pectoris. The patients were randomly divided into observation group and control group (100 cases). The control group was treated with routine nursing mode, and the patients in the observation group were treated with predictive nursing mode. The differences of hospitalization time and quality of life scores between the two groups were observed. The anxiety and depression of the two groups were observed before and after treatment, and the satisfaction of the two groups was observed. Results The scores of hospitalization and quality of life in observation group were better than those in control group (P<0.05). There was no statistically significant difference between SAS score and SDS score before treatment, but SAS score and SDS score of observation group were significantly lower than those of control group (P<0.05). The satisfaction degree of the patients in the observation group was better than that in the control group (P<0.05). Conclusion Predictive nursing has a good effect in the clinical nursing of patients with coronary heart disease and angina pectoris. It can effectively improve the patients' anxiety and depression, shorten the hospital stay and improve the quality of life. It is worth to be used in clinical practice.

Objective To investigate the infection rate of human papillomavirus (HPV) type 51 in the high-risk HPV(HR-HPV) tested positive samples and discuss the state of HPV51 in the host.Methods HR-HPV tested positive samples were tested by PCR methods to investigate the infection rate of HPV51 and the whole genome of HPV51 was amplified by PCR methods.Results 21 cervical samples were positive in 204 HR-HPV tested positive samples.We got five HPV51 whole genomes successfully.Conclusion The infection rate of HPV51 was 10.3％ and HPV51 genomes existed in an episomal state in the host.

Objective To investigate the infection rate and distribution of human papillomavirus type 39 in Beijing.Methods HPV genotyping detection coupled with cytological test of cervical exfoliated cells within 30 days were used for the patients from the People's Liberation Army General Hospital,between January 2013 to July 2014.Full-length genomes were amplified for the HPV39 positive samples.Results Among 19 018 samples,518 were HPV39 positive (2.72％).Two peaks were observed in the age groups 21-25 and 46-50 years old,with positive rate of 2.98％ and 2.44％ respectively.The prevalence of HPV39 in low-grade squamous intraepithelial lesion (LSIL) was 18.52％,higher than other cervical lesion groups.In addition,full-length genome amplifications were successful in five HPV39 positive samples.Conclusions In the studied population,HPV39 showed two increases in age groups,and abundance in LSIL.Episomal form of HPV39 viral genomes existed in the samples.

As a representative chemotherapeutic drug, docetaxel (DTX) has been used for breast cancer treatment for decades. However, the poor solubility of DTX limits its efficacy, and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4 (CXCR4) expression during the treatment. Herein, we conjugated CXCR4 antagonist peptide (CTCE) with DTX (termed CTCE-DTX) as an anti-metastasis agent to treat breast cancer. CTCE-DTX could self-assemble to nanoparticles, targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX efficacy. Thus, the CTCE-DTX NPs achieved promising efficacy on inhibiting both bone-specific metastasis and lung metastasis of triple-negative breast cancer. Our work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy.