Objective To discuss the adverse effect caused by capecitabine chemotherapy and its nuning measures.Methods A retrospective analysis was carried out for the adverse effect,occurrence regularity and nursing measures in 58 patients undergoing chemotherapy with capecitabine from June 2004 to December 2007.Results Handfoot syndrome happened in 30 cases,nausea and vomiting 23 cases,diarrhea 20 cases and stomatitis 15 cases in 58 patients.After positive prevention and effective nursing 57 patients successfully accomplished capecitabine chemotherapy.Only one patient withdrew due to grade 3 handfoot syndrome.Conclusions Positive prevention and eady detection and treatment can alleviate the adverse effect of capecitabine chemotherapy,so the psychological burden of patients can be relieved.

Objective To investigate the incidence of macrosomia in Ezhou of Hubei province of China,and analyze the in-fluencing factors in an attempt to provide scientific evidence for the prevention and intervention of macrosomia.Methods The incidence and change pattern of macrosomia were analyzed by reviewing the medical records of delivery between 2010 to 2014 in Maternal and Child Health Hospital of Ezhou City.Chi-square and logistic regression were used to analyze the lnfluencing fac-tors of macrosomia.Results The incidence of macrosomia in Ezhou city was 5.5% in 2010-2014,and it tended to decline by year.Univariate and multivariate analyses revealed that maternal age at delivery,gestational week,history of miscarriage and the infant gender were influencing factors of macrosomia.Conclusion The development of macrosomia is associated with many fac-tors.More attention should be paid to the pregnancy care to reduce the occurrence of macrosomia.

Objective To analysis the the effect of Ji Desheng Sheyao on coagulation,liver, kidney function in bee sting injury patients with severe toxic effect.Methods 42 bee sting injury patients with severe toxic effect were collected.Corresponding treatment and nursing measures were given respectively, after the treatment, the coagulation function,liver, kidney function and nursing effect were detected in all patients.Results After treatment compared with control group,there was no significant difference in the coagulation function of the patients in the experimental group;the serum levels of ALT,AST and TBIL were lower in the experimental group (P<0.05); the serum levels of BUN and Scr were lower in the experimental group(P<0.05);the incidence of complications was lower, and the nursing satisfaction was higher in the experimental group(P<0.05).Conclusions Ji Desheng Sheyao and good nursing measures can significantly reduce oxidative stress in patients with severe toxic effect , improve liver and kidney function, reduce the incidence of complications, improve patient care satisfaction.

Objective To evaluate the effect of transtheoretical model(TTM)-based health education on the self-care behaviors of patients with heart failure.Methods One hundred and fifty heart failure patients from January 2012 to June 2013 were randomly assigned to two groups,75 cases in each group.The patients in the experimental group received TTM-based health education;the patients in the control group received conventional health education.All patients were investigated with the Self-Care of Heart Failure Index (SCHFI) at baseline,1 month and 3 months after intervention.Results After intervention,the scores of self-care maintaining,self care management and self care confidence in the experimental group were significantly higher than those in the control group.Conclusions TTM-based health education can effectively improve the self-care behaviors of patients with heart failure.

This paper reviewed and analyzed the whole 29 years' compiling and revising histo-ry of Neurology the 5-year programming textbook for national undergraduates. The textbook has been becoming a high-quality textbook with novelty, practicability, readability and systematicness, conform-ing to the need of national education reform and reflecting the characteristics of neurology. Through the review of textbook history, we know that material construction can deepen the educational reform, improve the teaching level and discipline development, promote quality education and personnel train-ing.

Objective To establish the method for determining the content of Fructus Cnidii in Dafeng wan by HPLC. Methods Diamonsil ODS1 C18 column was used with CH3OH-0.1 mol/L (NH4)2SO4 (70︰ 30) [adjust pH to 2.5 by sulphuric acid solution (1→5)] as the mobile phase. The detection wavelength was set at 322 nm and flow rate was 1.0 mL/min. Results The calibration curve was linear at the range of 0.101～0.808 ?g for the Fructus Cnidii and linear equation was Y =9.964 406?10-3X -1.355 684?10-1, r=0.999 5. The average recovery was 98.4% and RSD was 1.40% (n=6). Conclusion This method was simple and accurate, with good specificity and repeatability, which provides scientific quantitative analysis method of Fructus Cnidii in Dafeng wan.

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease with unknown etiology,including ulcerative colitis (UC) and Crohn’s disease (CD).At present,as the global incidence of inflammatory bowel disease is increasing year by year,the role of the intestinal micro ecology in disease evolution has attracted more and more attention,and as an important part of gut microbes system,the intestinal fungus'changes and effects in disease states are unclear.This paper reviews on the intestinal fungus in the occurrence,development of inflammatory bowel disease from the composition and distribution of the intestinal fungus and its relationship with the gut bacteria,and the immune reaction.

Objective:To explore the effect of health education under KABP model on negative emotions and pregnancy outcome in patients with high-risk pregnancy.Methods:Choosing 180 patients with high-risk pregnancy as the research objectsfrom June 2014 to May 2016 in our hospital,we divided the patients into two groups using the random number table method,each for 90 cases.The control group was given comprehensive nursing;the observation group was given health education under KABP model on the basis of control group.We compared the differences of negative emotions and pregnancy outcome between the two groups.Results:Before nursing,there was no significant difference of the Self-Rating Anxiety Scale (SAS) score and Self-Rating Depression Scale (SDS) score between the two groups (P ＞ 0.05).After intervention,the fetal distress,neonatal asphyxia and postpartum hemorrhage rate of observation group were significantly lower than control group,while the rate of natural delivery of observation group was significantly higher than control group (P ＜ 0.05).Nursing satisfaction of observation group was significant higher than control group (P ＜ 0.05).Conclusion:The health education under KABL model helps to significantly improve negative emotions and pregnancy outcome in patients with high-risk pregnancy,thus significantly improve nursing quality.It is worthy of clinical popularization and application.

Treatment and the clinical outcome of patients with head and neck cancer are determined by accurate staging and assessment of the cervical lymph nodes for metastases is an important step of this process. Ultrasonography, ultrasonography-guided fine needle aspiration (FNA), CT, MRI and PET/CT are used in the assessment of cervical lymph nodes. Ultrasonography guided FNA is advantageous in ease of application, minimumal invasiveness to patients, and less contraindications. Combined with cell block and molecular biology, FNA can be an effective tool for the diagnosis. The present article reviewed the diagnostic value of ultrasonography guided FNA in cervical lymph node assessment in patients with head and neck cancer.

Objective To investigate the application of ureteral catheter in complicated gynecological laparoscopic surgery for the prevention of ureteral injury . Methods A total of 182 cases of gynecological laparoscopic surgery performed from January 2009 to November 2011 were selected as study group .Bilateral ureteral catheters were inserted under cystoscopy , and then laparoscopic surgery was performed under the instruction of the catheter .The catheter was immediately removed after the surgery .A total of 200 cases of laparoscopic surgery were selected as control group and preoperative ureteral catheterization was not applied in this group .The incidence rate of ureteral injury was compared between the two groups . Results The success rate of bilateral ureteral catheterization in the study group was 98.9%(180/182)and no ureteral injury occurred .In the control group, ureteral injury was found in 2 cases, which were converted to open surgery for ureter repair and double J stent was retained .The 2 cases recovered 2 months after the surgery.Bladder injury was found in 2 cases during the surgery , which received immediate repair assisted by surgeons from the department of urinary surgery and recovered 2 months after postoperative catheterization . No statistical difference was found in complication rate between the two groups ( P=0.125 ) . Conclusion The application of ureteral catheterization in complicated gynecological laparoscopic surgery can reduce the risk of intraoperative ureteral injury .