Conjunctiva ; surgery ; Diagnosis, Differential ; Eye Neoplasms ; metabolism ; pathology ; surgery ; Humans ; Infant ; Male ; Neoplasm Recurrence, Local ; Nerve Sheath Neoplasms ; metabolism ; pathology ; surgery ; Reoperation ; S100 Proteins ; metabolism

Animals ; Female ; Fetal Heart ; abnormalities ; diagnostic imaging ; surgery ; Heart Defects, Congenital ; diagnostic imaging ; physiopathology ; surgery ; Humans ; Pregnancy ; Treatment Outcome ; Ultrasonography, Prenatal

Objective To investigate the effects of apigenin on the migration of vascular smooth muscle cells (VSMC) induced by platelet derived growth factor (PDGF)-BB and the possible molecular mechanism. Methods VSMCs were isolated from thoracic aortas of male Sprague-Dawley rats using enzyme digestion method. Migration of VSMCs was determined by transwell assay. Western blotting was carried out to evaluate phosphorylation of c-jun N-terminal kinase (JNK). Results Treatment with PDGF-BB (20 ng·mL-1 ) significantly promote VSMC migration,the number of migrated cells was 2. 46 times than that of control group. However,after 12. 5 μmol·L-1 apigenin pretreatment,the number of migrated cells was 46. 5% of the PDGF-BB group. Various dose of apigenin can significantly inhibit VSMC migration induced by PDGF-BB,12. 5 μmol · L-1 apigenin treatment significantly inhibited PDGF-BB phosphorylation of JNK. Conclusion Apigenin can suppress the migration of VSMC induced by PDGF-BB. These beneficial effects on VSMC were at least partly mediated by the inhibition of activity of JNK.

Objective To evaluate the tolerance and efficacy of nasogastric enteral nutrition (NGEN) in the treatment of severe acute pancreatitis (SAP). Methods PUBMED, Web of Science and The Cochrane Central Register of Controlled Trials from 1966 to 2011 (up to October) and Chinese Journals Full-text Database (CNKI), Database for Chinese Technical Periodicals (VIP) and Wanfang Digital Journal Full-text Database from 1978 to 2011 (up to October) were retrieved to collect clinical randomized controlled trials of NGEN to compare with nasojejunal enteral nutrition (NJEN) in the treatment of SAP. Two reviewers independently screened the literature for eligibility and evaluated the quality with confirmation of cross-check. Different opinions would be decided by the third party. Statistical analysis was performed by meta-analysis using Review Manager 4.2. Results Three randomized controlled trails including 159 patients with SAP met the inclusion criteria, involving 82 patients in NGEN group and 77 in NJEN group. There was no significant difference between NGEN and NJEN group in the risk of mortality of SAP (RR=0.69, 95%CI: 0.37-1.29, P=0.25), conversion to surgery (RR=2.09, 95% CI: 0.55-7.92, P=0.28), diarrhea subsequent to enteral nutrition (RR=1.43, 95% CI: 0.59-3.45, P=0.43), rate of tube displacement (RR=0.42, 95%CI: 0.08-2.17, P=0.30) and pain related with enteral nutrition (RR=0.94, 95%CI: 0.32-2.70, P=0.90). While compared with NJEN, the risk of infectious complications was lower than NGEN (RR=0.64, 95%CI: 0.42-0.99, P=0.04). Conclusion In enteral nutrition support of SAP, NGEN is comparable to NJEN in efficacy and tolerance, but the former has the lower rate of infectious complications and easier to operate, and there is a tendency of NEGN to replace the latter.

The Pharmacopoeia of the People’s Republic of China 2025 edition is to be issued in March 2025. Chinese Pharmacopoeia is the basic requirements on the drug manufacture, drug testing, drug use and drug administration. The new edition Chinese Pharmacopoeia will be dramatically improved on the pharmacopoeia monographs included, establishing the standards system, standards conversion and application of drug quality control for the new technology, new method & new tool, drug control on the safety and effectiveness as well as the drug standard international harmonization. It will take important role on improving the drug quality, ensuring the safety of drugs for public use, strengthen technical support for drug administration, promoting the high-quality development of China’s medical and pharmaceutical industry. This paper introduces the development and revision of the Chinese Pharmacopoeia 2025 Edition,aim at helping the industries well understanding and implantation the new edition Chinese Pharmacopoeia.

ObjectiveTo explore the relations between the alkaline phosphatase(ALP) and the type of cerebral palsy. MethodsThe ALP level of 40 children with different types of cerebral palsy were examined with the Olympus AU-600 apparatus. ResultsThe ALP value of the children with spastic cerebral palsy is normal. The ALP value of the children with athetoid cerebral palsy is higher than spastic cerebral palsy(P<0.001).Conclusions The ALP value can help us to identify the type of cerebral palsy.

Nursing is a major of strong practice and operation.The purpose of clinical simulation teaching system is to meet the cultivation of clinical ability and the training of clinical skill of nursing students.This system adopted the cases teaching, applied the nursing program, and laid stress on forming the clinical thought and cultivating a good humanistic spirit.It also strives to solve the stringent phase of practice environment among the present nursing students through constituting a scientific and standard simulation teaching system.

Objective To observe the curative effects of Shuxuetong in treating patients with acute cerebral infarction and its effects on the level of serum C-reactive protein (CRP).Methods One hundred and twenty patients with acute cerebral infarction who had the onset within 48 h were equally randomized into treatment group and control group.Six ml Shuxuetong and Troxerutin for intravenous drip daily were given to the treatment group and the control group,respectively,for a consecutive 14 d.The concentrations of serum CRP in the 2 groups were measured by immunonephelometry before treatment and on the 5th,10th and 14th d of treatment.The scores of neurological functional deficit scale were compared before treatment and on the 14th d of treatment in the 2 groups.Results The concentration of serum CRP in the treatment group on the 5th,10th and 14th d of treatment was significantly lower than that in the control group (P<0.05).The scores of neurological functional deficit scale in the treatment group (14.57±7.88) were significantly lower than those in the control group (19.08±8.11) (P<0.05).The clinical efficacy between the 2 groups was obviously different (P<0.05).Conclusion Shuxuetoug can decrease the concentration of serum CRP and improve the nervous function in patients with acute cerebral infarction.

Objective To analyze the application of objective structured clinical examination (OSCE) in graduation examination of nursing undergraduate students to promote exam reform. Methods Multistation OSCE was carried out among 110 nursing undergraduate students of Grade 2006 in our school at the end of graduation practice, and the results were analyzed. Results Fine reliability and validity was found of OSCE. Authentic performance of the students was reflected. Conclusions OSCE is a scientific and effective evaluation of clinical nursing ability among nursing undergraduate students.