Introduction: The global impact of the coronavirus disease 2019 (COVID-19) pandemic has continually jeopardized vulnerable populations encompassing children, youth, elders, and individuals with immunodeficiency and comorbidities. Methods: In recognizing the crucial role of predictive analytics in shaping public health decisions, this study utilizes a predictive design, drawing on official data from the Department of Health (DOH) in the Davao Region, Philippines, spanning 57 days from March 15 to May 10, 2020. By comparing the Susceptible, Infected, Recovered (SIR) model and the Autoregressive Integrated Moving Average (ARIMA) model, the research aims to provide a scientific foundation for informed decision-making by public health authorities. Result: Analysis revealed that the SIR model emerged as the most effective in identifying trends and forecasting future cases. Despite both models indicating a substantial reduction in infection rates, caution is advised against discontinuing control and preventive measures due to the latent potential for another surge. The findings underscore the necessity for scientifically forecasted data to guide decision-makers in enhancing the responsiveness of public health services during similar and potentially worsening conditions. Conclusions Hence, this study contributes to the ongoing pandemic preparedness and responsiveness discourse. Its emphasis on predictive analytics, particularly the SIR model, offers valuable insights for authorities tasked with safeguarding public health. The significance lies in addressing the current situation in the Davao region and providing a template for future scenarios. As the world grapples with the unpredictable nature of infectious diseases, informed decision-making based on scientific forecasts becomes imperative for effective public health management.