Objective To search a better novae biomaterial applied to guide bone regeneration for promoting the healing of acute bone trauma by the experimental study of Haversian remodeling.Method Circular bone defects of 5mm diameter were created in tibias and the corners of mandibles in 36 rabbits.The defects were covered with calcium alginate film (CAF) in the experimental group, collagen membrane (CM)and no membrane (blank) in the control groups respectively. Healing conditions were analyzed using gross inspection, and histological and immunohistochemical studies after 1, 2, 4, 6 and 8 weeks respectively.Results The experimental group appeared more and earlier Haversian remodeling with osteoinductive factors leading to better bone regeneration. The control groups showed more macrophages with CM absorbed slowly, weak and delayed Haversian remodeling, and less osteoinductive factors ( P ＜ 0.05) in the early stage.Conclusions Calcium alginate film, as a relatively cheaper biomaterial, provided better effect than the collagen membrane on guided bone regeneration, because of its better Haversian remodeling and more content of osteoinductive factors shown in this experiment.

Objective:To evaluate the effect of occlusal adjustment on the restoration of the idiopathic cervical lesions.Methods:295 teeth with dental idiopathic cervical lesions in 83 patients were divided into 2 groups,142 teeth with occlusal interference were included in group 1 and the 153 without occlusal interference in group 2.The deffects of all the teeth were filled with Z350 nano-resin and followed up for 2 years.Then the teeth with treatment failure were divided into the experimental group (A,30 from group 1 and 14 from group 2) and the control group(B,30 from group 1 and 15 from group 2).The idiopathic cervical lesions of all teeth were filled with Z350 nano-resin,the occlusion of the corresponding teeth in group A was adjusted at the same time,that of group B was not treated.The cases were followed up for 1 year.Results:The success rate of group 1 and group 2 was 57.75％ and 81.05％ repectively (P ＜ 0.05).A subsequently treatment and 1 year follow-up showed that the success rate of gorup A and B for the cases with treatment failure of group 1 was 83.33％ and 56.67％ (P ＜ 0.05),for group 2 was 85.72％ and 40％ (P ＜ 0.05) respectively.Conclusion:The occlusal adjustment is benefit to the clinical effect of the treatment outcome of idiopathic cervical lesions.

IgG4-related disease is a novel clinical entity which can affect single or multiple organs.IgG4-related sialadenitis is referred to the salivary gland involvement of IgG4-related disease, with or without other organ involvement.IgG4-related sialadenitis is characterized by painless swelling or enlargement of salivary glands, high serum IgG4 level, abundant IgG4+ plasma cells infiltration with fibrosis histologically, and good response to glucocorticoids.With review of related articles, highlight and provide an overview of the most recent and focused findings and concepts of this disease, including the most significant pathogenic process based on kinds of immunocytes, cytokines, as well as participation of epithelial-mesenchymal transition, the clinical value of elevated serum IgG4 concentration and pathological role of infiltrated IgG4+ plasma cells, the potential relationship with salivary gland malignant tumor, the applying and usefulness of positron emission tomography-CT, the diagnostic utility of lip biopsy, treatment, prognosis, and also future perspectives.