1.Chronic Hepatitis E Virus Infection and Treatment in Organ Transplant Recipients.
Shu CHEN ; Feixue WEI ; Ting WU ; Ningshao XIA
Chinese Journal of Virology 2015;31(3):293-298
Hepatitis E, caused by hepatitis E virus (HEV) infection, usually leads to an acute clinical course, and is the most common diagnosis among cases of acute viral hepatitis. From 2008, there have been increasing reports of chronic HEV infection in immunocompromised patients such as organ transplant recipients. Without intervention with antiviral treatment, approximately 60% of HEV infections in organ transplant recipients evolve into chronic HEV infections. Of these chronic hepatitis E patients, 10% may develop liver fibrosis and progress to liver cirrhosis. This article reviews chronic HEV infection and treatment in organ transplant recipients.
Animals
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Antiviral Agents
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therapeutic use
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Hepatitis E
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drug therapy
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virology
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Hepatitis E virus
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genetics
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isolation & purification
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physiology
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Hepatitis, Chronic
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drug therapy
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virology
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Humans
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Transplant Recipients
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Transplants
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virology
2.Effects of OPRM1 A118G Gene Polymorphism on the Dosage of Opioids in Chinese Han Population Pa-tients with Cancer Pain
Ying LI ; Feixue WU ; Li SUN ; Xiang LI ; Yongzhong WANG
China Pharmacy 2016;27(20):2737-2739
OBJECTIVE:To provide reference for the individualized treatment of opioid drugs by investigating the effects of OPRM1 A118G gene polymorphism on opioids dosage in Chinese Han Population patients with cancer pain. METHODS:66 Chi-nese Han Population patients with medium and severe cancer pain were selected from a third grade class A hospital. Using fluores-cence in-situ hybridization,OPRM1 A118G genotypes were detected to compare the opioids dosage of different genotype in pa-tients with cancer pain. RESULTS:Among 66 patients,distribution frequency of AA,AG and GG genotype were 36.36%, 53.03% and 10.61%,respectively;those of A and G allele were 62.88% and 37.12%;the daily dosage of opioids in AA,AG, GG genotype patients respectively were(21.67±13.41),(42.00±32.18)and(87.14±73.65)mg,with statistical significance(P<0.001). Among 39 patients receiving opioids for the first time,the dosage of 6 AA genotype patients and 15 AG genotype patients had been adjusted,with statistical significance(P=0.026). After adjusting dosage,daily dosage of AA genotype and AG genotype patients were (16.11 ± 9.16) and(28.57 ± 18.52)mg,with statistical significance (P=0.011). CONCLUSIONS:OPRM1 A118G genotype can influence the dosage of opioid in Chinese Han Population patients with cancer pain,and gene polymorphism can be used as evidence for dosage guide of opioids.
3.Advances in epidemiological researches of Herpes zoster
Xinjing MA ; Feixue WEI ; Yingying SU ; Shoujie HUANG ; Ting WU
Chinese Journal of Microbiology and Immunology 2016;36(12):948-953
Herpes zoster ( HZ, also known as shingles) , caused by reactivation of latent varicella zoster virus ( VZV) , is a viral disease characterized by a painful skin rash with blisters involving a limited area. Elderly individuals older than fifty years of age are at increased risk of contracting HZ. In China, HZ becomes a significant health burden along with population aging. The virological characteristics, clinical di-agnosis, epidemiological characteristics of HZ are summarized in this review. Moreover, the burden of HZ, risk factors as well as the prevention and control of HZ are also discussed.
4.Applicated value of rosuvastatin in the treatment of coronary heart disease patients with diabetes
Shengzhi WU ; Xiaoke SHI ; Ruopei ZHU ; Yifei CHEN ; Feixue LIAO
Chinese Journal of Primary Medicine and Pharmacy 2014;(9):1334-1335
Objective To compare main adverse cardiac events of patients with coronary heart disease and diametes,but normal lipids after statin on lowering lipids , and to bring out necessity of early lowering lipids . Methods A total of 324 patients with coronary heart disease and diametes were enrolled ,LDL-C was measured in-hospital for all patients and LDL-C<3.36mmol/L suitable for the experiment .They were divided into statin group (n=176,rosuvastatin 10 mg/d)and control group(n=148)randomly,all patients received second prevention for cor-onary heart disease including anti-platelet,anti-myocardial ischemia,smoke quitting,adjust diets and exercise,the CAG or PTCA(and stent implanting),CABG.the end events were main adverse cardiac events (cardiac events,recur-rent angina and target vessel reconstruction ).The mean follow-up time was(13 ±6)months.Results The fasting plasma glucose,LDL-C,hs-CRP in statin group were all significantly lower than those of control group [FPG:(5.3 ± 0.9)vs.(6.7 ±1.2)mmol/L,P=0.042;LDL-C:(1.7 ±0.6)mmol/Lvs.(3.9 ±1.6)mmol/L,P<0.01;hs-CRP:(1.4 ±0.5)mmol/L vs.(3.8 ±1.2)mg/L,P <0.01],MACE were less(15.6% vs.37.1%,P =0.032). Conclusion Early statin on patient with coronary heart disease and diametes ,though normal lipids ,which can down-regulate main adverse cardiac events significantly .
5. The impact of male circumcision on the natural history of genital HPV infection: a prospective cohort study
Feixue WEI ; Meng GUO ; Xinjing MA ; Yue HUANG ; Ya ZHENG ; Lin WANG ; Yan SUN ; Sijie ZHUANG ; Kai YIN ; Yingying SU ; Shoujie HUANG ; Mingqiang LI ; Ting WU ; Jun ZHANG
Chinese Journal of Preventive Medicine 2018;52(5):486-492
Objective:
To analyze the correlation between circumcision and incidence and clearance of male genital HPV infection.
Methods:
From May to July 2014, 18-55 year old men who had sexual behavior history were recruited from the general population in Liuzhou, Guangxi to set up a cohort. Totally, 113 circumcised and 560 uncircumcised men were enrolled and interviewed using a questionnaire (including information on demographic characteristics and sexual behaviors), then they were followed-up with 6-month interval for 2 times. On each visit, specimens of male external genitalia were collected and genotyped for HPV DNA. The differences of incidence and clearance of genital HPV infections between circumcised and uncircumcised men were analyzed by Log-rank test. Cox regression was used to analyze the relationship between circumcision and incidence and clearance of HPV infection.
Results:
The median age (
6.Screening and identification of core genes for diabetic nephropathy
Xiaojun Wu ; Feixue Ni ; Yuxue Xu
Acta Universitatis Medicinalis Anhui 2024;59(4):610-618
Objective :
To screen the core genes of diabetic kidney disease ( DKD) based on bioinformatics , ex- plore the therapeutic targets of DKD , and discuss its possible regulatory mechanism .
Methods :
The expression da- ta matrix of glomerular transcriptome in patients with DKD in GEO database (GSE30528 , GSE47183) was extrac- ted , and the differentially expressed genes ( DEGs) were screened by bioinformatics methods to identify the core differential genes , and then gene expression and enrichment analysis (GSEA) were conducted to predict effective targets .
Results :
By screening and identifying the mRNA expression matrix of DKD , five core genes were screened out. Among them , C1orf21 and NPHS1 were significantly down regulated , and CD48 , COL1A2 , and TGFBI were up regulated . NPHS1 and CD48 were significantly related to immune differences , intercellular communication , and cell surface interaction . Through receiver operating characteristic curve ( ROC) analysis and GSEA analysis and drug target prediction , it might be of great significance for the treatment of DKD .
Conclusion
The core genes screened in this study have significant correlation with DKD , which may be used as effective markers for the treat- ment of diabetes . And then , this study provides a theoretical basis for the treatment and identification of DKD .