OBJECTIVE:To establish a method for simultaneously determining chloramphenicol,salicylic acid and metroni_ dazole in compound chloramphenicol tincture with no need for separation.METHODS:The concentrations of three main in?gredients were determined by multiwavelength coefficient spectrophotometry,the detecting wavelengths being277.5,297.0and317.0nm respectively.RESULTS:The average recoveries of chloramphenicol,salicylic acid and metronidazole were(100.22?0.74)%,(99.25?1.54)%and(99.79?1.92)%respectively.CONCLUSION:This method is simple,rapid and accurate.It is suitable for the determination of multicomonent preparation in hospital routine analysis.

Objective To evaluate the effect of preoperative transarterial chemoembolization (TACE) for resectable hepatocellular carcinoma (HCC).Methods HCC patients undergoing up-front hepatectomy (group A) were compared with those receiving TACE before hepatectomy (group B).Results Tumor size decreased significantly after TACE (t =3.3 1,P =0.021).The rates of tumor encapsulation and liver adhesions were significantly more often seen in group B.There were fewer tumor-residual and more frequent necrosis in group B.Operative time in group B was longer (t =2.71 ,P =0.046).The average blood loss and complication rate were of no difference between the two groups.The occurrence of pleural effusion and intrahepatic recurrence rate in group A was higher than group B (x2 =3.85 ,P =0.031) (x2 =2.76,P =0.046).The overall survival rate from the second year postoperative in group B was higher than group A (x2 =3.37, P =0.043).Conclusions TACE could diminish tumor, advance encapsulation and reduce tumor-residual.Preoperative TACE does not improve 1-, 2-, and 3-year tumor-free survival rates but improve 1-, 2-, and 3-year overall survival rates.