OBJECTIVE:To investigate the effect of prostaglandin E1 combined with atorvastatin on related indicators in elderly patients with hypertensive nephropathy. METHODS:70 elderly patients with hypertensive nephropathy were randomly divided into control group and observation group. Control group was orally given 10 mg Atorvastatin calcium tablet,once a day;observation group was additionally given 10 μg Prostaglandin E1 injection,adding into 250 ml 0.9% Sodium chloride injection by intravenous infusion,once a day. The treatment course for both groups was 2 weeks. All patients were given quality low-protein,low-salt and low cholesterol diet,depressurization,lipid-lowering and other conventional treatment. Heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure(DBP),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C),serum creatinine(Scr),24h urinary protein(TP/24 h),microalbuminuria(mAlb),uri-nary β2-microglobulin (β2-MG),blood urea nitrogen (BUN) before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:After treatment,HR,SBP,DBP,TG,TC and LDL-C in 2 groups were significantly lower than before,and difference was statistically significant(P<0.05),but there was no significant difference in the above-mentioned in-dicators between 2 groups and HDL-C before and after treatment(P>0.05);Scr,TP/24 h,mAlb,β2-MG and BUN were signifi-cantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). And there was no significant difference in the incidence of adverse reactions(P>0.05). CONCLUSIONS:Based on the con-ventional treatment,prostaglandin E1 combined with atorvastatin can effectively improve the HR,blood pressure and blood lipid of elderly patients with hypertensive nephropathy;however,prostaglandin E1 combined with atorvastatin is better than atorvastatin alone in aspect of protecting renal function,with similar safety.