1.Effect of Shenqi Fuzheng injection on immune function and quality of life in patients with advanced gastric cancer chemotherapy
Beina LU ; Feifang WANG ; Ying HUANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):136-137
Objective To study the effect of Shenqi Fuzheng injection on immune function and quality of life in patients with advanced gastric cancer.Methods 100 Patients with advanced gastric cancer treated from July 2014 to April 2017 in our hospital were randomly divided into two groups.The patients in the control group were treated with conventional FOLTOX regimen.The patients in the experimental group received Shenqi Fuzheng injection.The immunological function and quality of life of the two groups were analyzed and analyzed.Results Compared with the control group, the content of CD3+ was significantly improved in the patients treated with Shenqi Fuzheng Injection, the content of CD8+ was effectively decreased and the CD4+ / CD8+ ratio was effectively improved.Shenqi Fuzheng injection can effectively improve the immune function of patients, the difference was statistically significant(P<0.01).The number of patients in the treatment group was 39, and the control group was 26, the difference was statistically significant(x2 =7.43, P<0.01).There were 40 patients with sleep improvement in the treatment group and 25 patients in the control group, the difference was statistically significant(x2 =9.89, P<0.01).Conclusion Applying Shenqi Fuzheng Injection on FOLTOX can effectively improve the immunity of patients and improve the quality of life.Shenqi Fuzheng injection in clinical worthy of promotion.
2.Effect of aerobic inhalation of salbutamol on chronic obstructive pulmonary disease and psychological intervention
Yue LI ; Feifang WANG ; Qiong LIU ; Yanan LI
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):332-333,336
Objective To study the clinical effects of inhalation of albuterol and the treatment of chronic obstructive pulmonary disease in the treatment of chronic obstructive pulmonary disease.Methods Choose 88 cases of patients treated in our hospital, it can be divided into two groups, separately carries on the routine therapy, salbutamol aerosol inhalation therapy, and routine health education and psychological intervention.The clinical outcomes and anxiety were analyzed in the two groups.Results The curative effect of observation group, anxiety, improve the situation, obviously better than the control group, all the data through a detailed comparison between groups, the difference was statistically significant(P<0.05).Conclusion Chronic obstructive pulmonary disease, the use of albuterol atomization inhalation and combined psychological intervention, the treatment effect is good.
3.Content Determination of 18 Amino Acids in Compound Amino Acid Injection by HPLC with Pre-column PITC Derivatization
Yuan WANG ; Hailong WANG ; Gaowa JIN ; Feifang ZHANG ; Bingcheng YANG ; Xinmiao LIANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(6):1347-1352
An efficient and sensitive analytical method for the simultaneous content determination of 18 amino acids in compound amino acid injection was developed using high performance liquid chromatography (HPLC) with pre-column derivatization. Phenyl isothiocyanate (PITC) was used as derivatization reagent. The target compounds were separated on a Unitary-C18 column (250 mm í 4.6 mm, 5 μm) in gradient elution mode using sodium acetate and the mixture of acetonitrile, methanol and water as mobile phases. The detection wavelength was 254 nm. The derivatization reagent dosage, derivatization time, salt concentration, the pH and the column temperature of mobile phase were investigated. Finally, 18 amino acids were separated within 40 minutes. The method showed that the good linearity (r2 ≥ 0.997 7) was at a range from 9 μg·mL-1 to 1 021 μg·mL-1. The recoveries ranged from 92.6% to 110.7%. And the relative standard deviations (RSD) ranged from 0.01% to 5.68%. The limits of quantification (LOQ, S/N = 10) ranged from 0.02 μg·mL-1 to 13.41 μg·mL-1. This method, which was simple, sensitive and accurate, can be applied for the content determination of amino acids in compound amino acid injections.
4.Efficacy of epidural autologus blood patch under X-ray guidance in patients with spontaneous intracranial hypotension
Feifang HE ; Taidi ZHONG ; Ping WANG ; Chunhong XU ; Suming TIAN ; Li WANG ; Jin WANG ; Xingyue HU ; Ishikawa SHINICHI ; Nishie HIROYUKI
Chinese Journal of Anesthesiology 2009;29(3):212-214
Six patients(3 male,3 female)aged 33-66 yr, Course of disease 6-35 days, diagnosed with spontaneous intracranial hypotemion in Sir Run Run Shaw Hospital from November 2007 to May 2008,Were treated with on epidural autologus blood patch trader X-ray guidance. According to the results of CT myelography. the puncture site Was chosen in the 1-2 vertebral interspaees below the site of a single eerebrospinal fluid leak. For patients with multiple cerebrospinal fluid leaks.the procedure was performed at the spinal cord segment of the most severe leak. The mixture of augous blood and Omnipaque(300g/100 ml)at a ratio of 2:1 was injected into the epidural space to cover the spinal cord segment of the leaks under C-arm fluoroscopic guidance.Side effects were recorded during and after the injection of autologus blood.The treatment was repeated one week later if the former one failed.One patient was treated with epidural blood patch 3 times.and the rest 5 patients were treated with epidural blood patch 1 time.During the injeetion of autologus blood,5 patients complained of pain in the purtclure site,2 experienced pain radiating to the upper limb,2 felt,numbness in the right leg and all of these syndromes could be self-relieved.No side effects were observed after the injection of autologus blood.All the patients were Cured and no recurrence was observed during a 2-6 month follow-up.