AIM:To analyze the clinical significance of axial length, diopter and retinal nerve fiber layer thickness in hyperopia children with anisometropia amblyopia. ·METHODS: From January 2015 to January 2017 in our hospital for treatment, 103 cases, all unilateral, were diagnosed as hyperopia anisometropia amblyopia. The eyes with amblyopia were as experimental group ( 103 eyes), another normal eye as control group (103 eyes). We took the detection with axial length, refraction, foveal thickness, corrected visual acuity, diopter and the average thickness of retinal nerve fiber layer. ·RESULTS: Differences in axial length and diopter and corrected visual acuity were statistically significant between the two groups (P<0. 05). The two groups had no significant difference in retinal nerve fiber layer thickness (P>0. 05). There was statistical significance difference on the foveal thickness (P<0. 05). There was a negative correction correlation between the visual acuity, axial length with foveal and peripapillary nerve fiber layer thickness, but no significant difference in correlation ( P>0. 05 ). The positive correlation between diopter with nerve fiber layer thickness of foveal and around the optic disc were no statistically significant difference (P>0. 05). ·CONCLUSION:Retinal thickness of the fovea in the eye with hyperopic anisometropia amblyopia were thicker than those in normal eyes;the nerve fiber layer of around the optic disc was not significantly different between the amblyopic eyes and contralateral eyes. The refraction and axial length had no significant correlation with optic nerve fiber layer and macular foveal thickness.

Accidents, Occupational ; Adult ; Female ; Humans ; Male ; Phosgene ; analogs & derivatives ; poisoning

Attention deficit and hyperactivity disorders (ADHD),a neurodevelopmental disability with core symptoms of inattention,hyperactivity and impulsivity increases the risk of many cognitive problems.However,the brain structures and pathways involved in the interplays between the core symptoms,such as activity deficits,and cognitive impairments have remained unknown over the past decades.This article review the academic developments in recent years that elucidate the neural mechanisms involved in the sensorimotor-cognitive difficulties at systematic,circuitry,cellular,and molecular levels.The treatment potentials of physical activity enhancement were addressed,as a new alternative and supplementary therapeutic strategy for ADHD,based on our current understanding of the neurobiology of cognitive-sensorimotor interaction.

Objective:To study the effects of the Lonicera on immediate hypersensitiviy,and to provide pharmacological clues for the further clinical practice.Methods:The effects of Lonicera on both the heat-unstable PCA and the heat-stable PCA experiments of the mice were observed,and the changes of the histamine levels in the ovalbumin-induced allergic mouse's intestines after administrating the Lonicera were detected by observing the histopathologic changes with either HE stain or toludine blue stain and measuring the levels of histamine in the intestines with a fluorescent method.Results:The high and the middle coneatracions of the Lonicera could inhibit the heat-unstable PCA activity in the mice( P 0.05).The high and middle concentracions of the Lonicera were significantly effective,in increasing the percentage of the intact intestinal mast cells( P

This article started to be discussed experience in construction of Beijing base of philosophy and social sciences,with strategic position,break system and ideas,encourage the NGOs' attending the bases,put forward through includes:improve the understanding of the importance of philosophy and social sciences,establish a scientific system,increase capital investment to solve the key problems of hinder the development of bases.In-depth study and expand the main function and role of research base from strategic soothsaing,scientific development,increase power,innovation,fault tolerant,etc.

Acute pancreatitis has uncertain and complicated conditions,and non -surgical treatment is mainly used during the early stage. However,as for the causes of acute pancreatitis in early stage,timely surgical intervention should be given to control some causes.This arti-cle also elaborates on the application of percutaneous drainage and video -assisted minimally invasive surgery.It is pointed out that there are still controversies over the advantages and disadvantages of minimally invasive surgery and conventional laparotomy and how to select video -assisted minimally invasive surgery,and that in depth studies are still needed in future.

Objective To study and compare the clinical effect of laparoscopic partial nephrectomy and open partial nephrectomy for renal tumor.Methods 60 renal tumor patients underwent partial nephrectomy were selected as the research subjects.They were randomly divided into two groups.30 cases of the control group received open surgery, 30 patients of the observation group received the implementation of laparoscopic surgery.The postoperative recovery, complication rate, renal function indicators were compared between the two groups.Results The operation time between the two groups had no statistically significant difference[(110.06±28.76)min vs.(108.43±29.64)min,t=0.216,P=0.830].However, the amount of intraoperative blood loss was significantly less in the observation group[(45.17±16.42)mL vs.(132.46±41.37)mL,t=10.742,P=0.000].The gastrointestinal function recovery time, hospitalization time of the observation group were significantly shorter than those of the control group[(2.48±1.07)d vs.(4.96±2.39)d,(7.31±4.32)d vs.(12.59±5.18)d,t=5.187,4.288,P=0.000,0.000].The incidence rate of complications of observation group was significantly lower than the control group (3.33% vs.20.00%,x2=4.043,P=0.044).After operation, the glomerular filtration rate of the two groups had no statistically significant difference compared with pre-operation[(42.18±5.42)mL/min vs (42.93±5.16)mL/min,t=0.549,P=0.585],and after operation, the comparison between the two groups also had no statistically significant difference[(41.34±4.96)mL/min vs.(40.85±5.08)mL/min,t=0.378,P=0.707].Conclusion The safety of retroperitoneal laparoscopic partial nephrectomy for renal tumor is reliable, the effect on renal function is not obvious, compared with open surgery, laparoscopic surgery can reduce surgical trauma, faster postoperative recovery.

Objective To investigate the effect of Celebrex on hemorheology and levels of serum intercelluar adhesion molecule-1 (sICAM-1),serum vascular cell adhesion molecule-1 (sVCAM-1),tumour necrosis factor-α (TNF-α),interleukin-6 (IL-6) in patients with delayed fracture healing.Methods 201 patients with delayed fracture healing in our hospital were randomly divided into observation group (n =101) and control group (n =100).The patients in control group received conventional surgical internal fixation,while patients in observation group received conventional surgical internal fixation combined with Celebrex.The clinical efficacy was observed,while the changes of hemorheology and levels of sICAM-1,sVCAM-1,TNF-α,IL-6 were compared between two groups before and after treatment.Results The effective rate of observation group was 94.1％,which was significant higher than that of control group 70.0％ (P＜0.01).There were no significantly differences between two groups in the indexes of hemorheology and levels of sICAM-1,sVCAM-1,TNF-α,IL-6 before treatment (P＞0.05).The indexes of hemorheology and levels of sICAM-1,sVCAM-1,TNF-α,IL-6 were significantly reduced after treatment,while the decreased degrees of observation group were better than those of control group,with statistically significant difference (P＜0.05).Conclusions Celebrex can improve the indexes of hemorheology,reduce the levels of sICAM-1,sVCAM-1,TNF-α,IL-6 and improve the clinical effect in treatment of delayed fracture healing.It is worth of popularization and application.

AIM:To observe the changes in vascular endothelial growth factor (VEGF) expression and the cell numbers of cellular necrosis in hippocampus CA1 area after cerebral ischemia and hypothermia postconditioning (HPC). METHODS: The focal thrombotic cerebral ischemia was induced by photochemical reaction in tree shrews. 6 h after ischemia, HPC was executed by a focal homoeothermic equipment, which reduced the brain temperature and maintained at 31-32 ℃ for 1 h. VEGF expression in hippocampus CA1 area was detected by immunohistochemistry. The numbers of death cells were counted and the ultrastructure was observed under the electron microscope. RESULTS: Compared to control group, VEGF expressions increased in neuron of hippocampus CA1 area at 24 h, and decreased at 72 h in HPC group (P

Pancreatic cancer is the fourth most common cause of cancer death,with a 5- year survival rate of less than 5％.The management and prognosis of the patients have remained dismal due to higher resistance of cancer cells to conventional approaches including surgery,radiation and chemotherapy.Therefore,there is a need for development of specific and sensitive tumor marker for pancreatic cancer.Caveolin- 1 is an essential constituent of caveolae and interacts with a variety of cellular proteins and regulates cell- signaling events.In this review,we survey the functional roles of caveolin- 1 in pancreatic cancer and argue that caveolin-1 regulates multiple cancer-associated processes including tumor growth,cell invasion,metastasis,cell apeptosis.However,Caveolin-1 has been reported to impact both positively and negatively on various aspects of pancreatic cancer progression.The function of caveolin- 1 is interdependent on tumor stage and the expression of some signaling pathways that impact on its role during tumor progression.