1.Application of Embedded System to Medical Equipment
Chinese Medical Equipment Journal 1989;0(04):-
Objective To discuss the possibility of application of embedded system to medical equipment. Methods The principle and actuality of embedded system were explained, and a concrete example was presented. Results The application of the embedded system to medical equipment reduced the cost of medical equipment, and increased the realtime capability, reliability and longevity of medical equipment. Conclusion More and more embedded systems are being applied to medical equipment. Medical equipment based on embedded system have been developed ceaselessly.
2.Research Progress of Multidrug Resistance of Breast Cancer
Chinese Journal of Bases and Clinics in General Surgery 2004;0(01):-
Objective To review the recent studies on the multidrug resistance of breast cancer. Methods The literatures of recent years on the studies of multidrug resistance, multidrug resistance protein and breast cancer resistance protein were reviewed. Results Multidrug resistance resulted from multiple factors. How to identify the sensibility of chemotherapy drugs and select individual therapeutic regime early were important to improve the survival rate and life quality of breast cancer patients.Conclusion These studies on multidrug resistance of breast cancer are helpful to predicting the effect and outcome of chemotherapy and overcoming the barrier of drug resistance.
3.Progress in the research of integron in bacterial resistance
Chinese Journal of Laboratory Medicine 2017;40(1):7-10
Integron was a novel bacterial resistance gene horizontal transmission element.In recent years, many researchers made a lot of research on the resistance mechanism of pathogen.In this paper, the detection and the novel discovery of the integron gene cassette were summarized , including Enterobacteria, Acinetobacter baumanii, Pseudomonas aeruginosa and other bacteria , on the basis of the multidrug resistance mechanism mediated by integron.The prospect the research was descixbed and more attention should be paid to the prevention and control of multidrug resistant bacteria.
4.Anticoagulation therapy for stroke prevention in patients with nonvalvular atrial fibrillation
International Journal of Cerebrovascular Diseases 2012;20(5):347-350
Patients with nonvalvular atrial fibrillation are the high-risk population of ischemic stroke.Anticoagulation therapy is mainly used to prevent the occurrence of stroke in clinical practice.However,there are some difficulties in the conventional administration of oral anticoagulant warfarin because of some restrictions.There are a number of novel oral anticoagulants with promising data for the prevention of stroke in nonvalvular atrial fibrillation,such as direct thrombin inhibitor and coagulant factor X a inhibitor.
5.Diagnosis of the Vulnerability of Carotid Atherosclerosis Plaque
International Journal of Cerebrovascular Diseases 2008;16(11):852-857
The vulnerable carotid atherosclerosis plaque is an important risk factor for ischemic stroke.However,there are no objective diagnostic criteria for the vulnerability of carotid atherosclerosis plaque in clinical practice now.This article reviews the progress in the diagnosis of vulnerable plaque from the aspects of ultrasound,CT,MRL cerebral angiography,and biochemical indexes.
7.Risk factors for intracranial atherosclerotic stenosis
International Journal of Cerebrovascular Diseases 2012;20(4):278-283
Intracranial atherosclerotic stenosis mostly occurs in Asians,blacks and Hispanicsis,which is the most important reason for the occurrence and recurrence of ischemic stroke.The current studies mainly concentrate on the aspect of the relationship between the intracranial atherosclerotic stenosis and the traditional risk factors.With the development of genetic technology,the relationship between the genetic factors and intracranial atherosclerotic stenosis has also received increasing attention.This article reviews the advances in research on the traditional risk factors for intraeranial atherosclerotic stenosis and genetic research.
8.Research Progress of Exemestane in Treatment of Breast Cancer
Chinese Journal of Bases and Clinics in General Surgery 2003;0(06):-
Objective To determine the investigation progression on exemestane in the treatment of breast cancer. Methods The literatures of recent years on the studies of exemestane were reviewed. Results Exemestane is an effective steroidal aromatase inactivator with superior tolerability, safety and efficacy in the adjuvant, neo-adjuvant and metastatic therapy of breast cancer. Conclusion With the progression of clinical trial with exmestane, exemestane will be regarded as an important drug in comprehensive therapy of breast cancer.
9.Evaluation of gastric lavage effi ciency and utility using a rapid quantitative method in a swine paraquat poisoning model
World Journal of Emergency Medicine 2020;11(3):174-181
BACKGROUND: Gastric lavage (GL) is one of the most critical early therapies for acute paraquat
(PQ) poisoning; however, details of the treatment protocol remain to be established.
METHODS: A rapid quantitative method involving sodium dithionite testing was developed.
It was validated for the determination of the PQ concentrations in gastric juice and eluate samples
from a swine acute PQ poisoning model with early or delay GL, or without. The vital signs, laboratory
testing, and PQ plasma concentrations were collected for therapeutic effect evaluation.
RESULTS: The reaction conditions of the test were optimized for two types of samples. Early
GL at one hour (H1) could improve the signs and symptoms after acute PQ poisoning at 24 hours
(H24). In contrast, GL at 6 hours (H6) could only partially relieve the vital signs. The H1 GL group
effectively reduced the peak of the plasma PQ concentration. In addition, the PQ concentrations in
the plasma and the gastric juice were signifi cantly decreased in both the GL groups as compared to
the untreated group at H24. Moreover, there was no signifi cant difference in the washing effi ciencies
calculated from the total eluates between the two GL groups. However, the washing effi ciency of the
fi rst 10 L eluate is superior to that of the additional 10 L eluate.
CONCLUSION: GL only at early stage may it benefit PQ poisoning in an animal model. The
currently used 20 L GL volume may need to be reduced in view of the low washing efficiency in
the later 10 L eluate. The rapid quantitative method can be used for gastric juice sample and has a
certain value for clinical GL practices.