Objective To explore the distribution of pathogens in lower respiratory tract infection, and to explore the drug resistance, and summarize the clinical experience.MethodsFrom February 2014 to August 2016 in Changxing county people's hospital, the specimens of the patients with lower respiratory tract infection were analyzed.Distribution of pathogenic bacteria was analyzed and its drug resistance was summarized.ResultsA total of 100 strains of bacteria were isolated, including 27(27%) strains of fungi, 26(26%) strains of gram positive bacteria, 47(47%) strains of gram negative bacteria.The proportion of gram negative bacteria was significantly higher than that of gram positive bacteria and fungi, and the difference was statistically significant (P<0.05).Different pathogenic bacteria have different drug resistance to commonly used antibiotics.The resistance of Candida albicans to fluconazole was 100.0%, the resistance of Staphylococcus aureus to compound sulfamethoxazole was 90% and to gentamicin was 100.0%, the resistance of Escherichia coli to levofloxacin was 100.0%.ConclusionGram negative bacteria accounted for the highest proportion in pathogen of lower respiratory tract infection.Different pathogenic bacteria have different resistance to different antibiotics in clinical, and monitoring and rational use of drugs should be strengthened in order to improve the efficacy and reduce drug resistance.