0.05). Conclusion Blood stasis syndrome is more common in AHS. PBC&RBS had some effects on AHS.

Objective To analyze dynamic features of TCM syndrome elements according to the neuropsychological characteristics of cognitive function impairment after ischemic stroke.Methods The hospitalized cerebral infarction patients without dementia were evaluated dynamically with the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) (Beijing Version) after IQCODE screens at different phase points.And they were divided into groups according to the severity of cognitive function impairment.The occurring frequency of TCM syndrome elements at all phase points for diagnosis was compared.Results The phase points and TCM syndrome elements closely related with the cognitive function impairment after ischemic stroke were as following:the 3rd day with fire and yin deficiency,the 7th day with yin deficiency,the 1st month with fire,phlegm,and blood stasis,and the 3rd month with fire,phlegm,blood stasis,qi deficiency,and yin deficiency.Conclusion The neuropsychological characteristics of cognitive function impairment of ischemic stroke are closely related with TCM syndrome elements and their evolvement as well as their different combinations.

BACKGROUND:The elderly hip fracture patients with chronic obstructive pulmonary disease (COPD) have a higher postoperative mortality than those only with hip fractures. In recent years, it has become an issue of concerns. Because the mechanism is unknown, however, there are no effective clinical interventions for these patients. OBJECTIVE:To observe the effect of bone marrow stromal stem cel s (BMSCs) on the level of pulmonary inflammation in aged rats with chronic obstructive pulmonary disease (COPD) after hip fractures. METHODS:Thirty male Sprague-Dawley rats, 12 months old, were exposed to smoking for 4 months and randomized into three groups, smoking, smoking+hip fracture+normal saline, smoking+hip fracture+BMSCs groups. Animal models of hip fracture were made in the latter two groups. Twenty-four hours after hip fracture, the lower lobe and peripheral blood samples were taken from al rats in the three groups, to evaluate the pathological changes of lung tissue and detect levels of inflammatory factors in the lung tissue and peripheral blood. RESULTS AND CONCLUSION:After closed hip fracture, aged COPD rats exhibited inflammatory cel infiltration, mucus secretion, airway stenosis or occlusion;the levels of interleukin-6, tumor necrosis factor-αand interleukin-10 in the lung tissue and peripheral blood were increased. After intravenous injection of BMSCs, the pathological changes of the lung tissue were reduced, and the levels of pro-inflammatory factors, tumor necrosis factor-αand interleukin-6, decreased, but the level of anti-inflammatory factor interleukin-10 further increased, which were significantly different from those in the normal saline group (P<0.05). These findings indicate that BMSCs can relieve acute lung injury in aged COPD rats with hip fractures.

Objective To investigate the effect of pathophysiology case-based learning(CBL)method on scores of pediatrics.Methods Undergraduates from 2005 grade at Chengde medical college were divided into two groups:experimental group(n=138,CBL method)and control group(n=136,conventional teaching method).The scores of pediatrics between the two groups were compared.The pediatrics test paper was divided into two types:type B,which was tightly connected with the pathophysiology knowledge and type F,which had less connection with pathophysiology knowledge.The accuracy rates of both groups were compared.Correlation analysis on scores between pathophysiology and internal medicine,surgery,pediatrics,obstetircs and gynaecology was made.Results No significant difference in total scores of pediatrics was observed between the two groups(P＞0.05);total accuracy rate of experimental group was higher than that of control group(P＞0.05);similar total accuracy rates of type F test paper were observed in both groups(P＞0.05);positive correlations in scores between pathophysiology and internal medicine,surgery,pediatrics,obstetircs and gynaecology were found.Conclusions Satisfactory long-term effect are received by applying pathophysiological CBL model since it can promote the application of pathophysiological knowledge in pediatrics,however,no apparent effect on students'clinical ability can be obtained from the mere application of CBL in pathophysiology course.

Objective:Based on network pharmacology to study the mechanism of Shaoyao-Gancao Decoction in treating tension-type headache. Methods:Searched for the active ingredients and potential targets of Shaoyao-Gancao Decoction from TCMSP database, and adopted the targets of tension-type headache from GeneCards, DisGeNET, Drugbank and OMIM databases. Then obtained all the intersections of Shaoyao-Gancao Decoction and tension-type headache, and uploaded them to the STRING databases to construct a PPI network and conduct topological properties analysis. Finally, established a Chinese medicine regulatory network of Chinese medicine-components-target genes-disease by Cytoscape 3.6.1 software. To perform the GO function enrichment analysis and KEGG analysis on the core targets. Results:There were 51 intersections of Shaoyao-Gancao Decoction and tension-type headache. The topological properties analysis suggested that CASP3, JUN, HSP90AA1, MAPK1, STAT3, CCND1, ESR1, RELA, PTGS2, MAPK14 may be the potential targets for the treatment of tension-type headache in Shaoyao-Gancao Decoction. Gene ontology enrichment analysis showed 876 biological processes, 101 molecular functions and 62 cellular components. KEGG pathway enrichment analysis showed 25 related signaling pathways, including TNF signaling pathway, serotonergic synapse, NOD-like receptor signaling pathway, Dopaminergic synapse and Sphingolipid signaling pathway. Conclusion:The treatment of tension-type headache by Shaoyao-Gancao Decoction verified the characteristics of multi-component, multi-target and multi-pathway, which provided reference for the clinical medication.

Objective To evaluate the efficacy of ketorolac versus tramadol used in analgesia during percutaneous vertebroplasty(PVP)in patients with osteoporotic vertebral compression fracture(OVCF).Methods This retro-spective study selected 126 patients who underwent PVP for treatment of osteoporotic vertebral compression fracture.Among them,there were 35 males and 91 females,with an age range of 60-82 years and an average age of 71.2±6.5 years old.The patients were divided into two groups:ketorolac group and tramadol group.Operation time and analgesic consumption of the two groups were recorded and compared;The mean artery pressure(MAP)and heart rate(HR)were recorded at following times point:entering operation room(T0),beginning of surgery(T1),in-jection of bone cement into the vertebral body(T2),ending of surgery(T3);pain visual analogue scale(VAS)were recorded at admission,after analgesic medication,intraoperative maximum,at discharge and 1 year after sur-gery;Oswestry disability index(ODI)1 year after surgery,satisfaction scores of patient,adverse events happened intraoperatively and postoperatively were also collected for comparison.Results There was no difference in general data between the two groups.The values of HR and MAP at T1,T2 and T3 were significantly lower in the ketorolac group compared to tramadol group(P＜0.05);No difference in VAS scores between the two groups of patients was observed at admission,discharge,and follow-up.Ketorolac group showed significantly lower VAS scores than tram-adol group after analgesic medication and during surgery(P＜0.05);There was no difference in the treatment course of preoperative analgesics between the two groups.The dosage of intraoperative analgesics in ketorolac group was significantly lower than that in tramadol group,and the difference was statistically significant(P＜0.05).The operation time in the ketorolac group was significantly shorter than that in tramadol group,and patient satisfaction was significantly higher than that in tramadol group(P＜0.001).There was no difference in pre-operative and post-operative ODI scores between the two groups.The incidence of post-operative nausea was significantly lower in ke-torolac group than in the tramadol group(P＜0.05).Conclusions Ketorolac can effectively shorten operation time,reduce the pain intensity of patients with osteoporotic vertebral compression fracture,and can decrease the occur-rence of postoperative nausea and improve patient satisfaction.

Objective:To investigate the application effect of scenario infiltration combined with interactive teaching in the teaching of nursing interns in the department of infectious diseases.Methods:A total of 120 nursing students who received training in Department of Infectious Diseases, Beijing Luhe Hospital Affiliated to Capital Medical University, were selected as subjects; 58 nursing students who received routine teaching were enrolled as conventional teaching group, and 62 nursing students who received scenario infiltration combined with interactive teaching were enrolled as combined teaching group. The two groups were compared in terms of self-evaluation teaching effect, nurse-patient communication ability, assessment scores, awareness of protection, and teaching satisfaction. SPSS 22.0 was used for the t-test and the chi-square test. Results:After the end of internship, compared with the conventional teaching group, the combined teaching group had significantly higher self-evaluation scores of learning interest, thinking ability, operational skills, teamwork awareness, and problem-solving ability ( P<0.05), significantly higher scores of planning and preparing, initiating communication, collecting and providing information, obtaining and understanding patient perspectives, and ending communication ( P<0.05), and significantly higher assessment scores of theoretical knowledge, nursing operational skills, and emergency and rescue abilities ( P<0.05). Compared with the conventional teaching group, the combined teaching group had a significantly higher proportion of nursing students who correctly disposed medical waste (96.77% vs. 79.31%) and a significantly lower proportion of nursing students with insufficient self-protection ability (4.84% vs. 22.41%). Compared with the conventional teaching group, the combined teaching group had significantly higher satisfaction scores of teaching content, course design, and teaching effect ( P<0.05). Conclusion:The application of scenario infiltration combined with interactive teaching can better meet the teaching needs of nursing interns in the department of infectious diseases and effectively improve their communication skills, comprehensive abilities, and awareness of protection, and therefore, it holds promise for further application.