Objective To optimize technology of three can group dynamic countercurrent extraction process of ferulic acid from Angelicae Sinensis Radix.Methods The content of ferulic acid was determined by HPLC. With content of ferulic acid as index, comprehensive test was used to investigate effect of extraction solvent and extraction time on extraction efficiency.Results The optimum process parameters were as follows:extraction solvent with 10 times of water;20 minutes for each extraction time.Conclusion The process which uses method of three can group of dynamic countercurrent extraction of ferulic acid from Angelicae Sinensis Radix is reliable, highly efficient and energy saving.

Objective To investigate the internal and external factors of scientific and technological innovations in pro-vincial maternal and child health care institutions and propose effective strategies for facilitating the innovations.Methods The PEST-SWOT model was used to analyze the internal strengths and weaknesses,external opportunities,and threats of the scientific and technological innovations in a provincial maternal and child health care institution from the perspectives of political,econom-ic,social,and technical environment.Results The institution has advantages and opportunities in policy support,scientific re-search management and investment,and disciplinary characteristics.However,it faces some threats and has disadvantages in tal-ent team,information-oriented level,and industrial competition.Conclusion The development of scientific and technological in-novation in provincial maternal and child health care institutions is affected by internal and external factors.It is necessary to firmly seize opportunities and comprehensively promote scientific and technological innovations from the aspects of medical treat-ment,teaching and research collaboration,discipline layout,talent team,and information-oriented construction.

Objective To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome.Methods A case-control study was performed.According to inclusion and exclusion criteria,among the staff members of enterprises and public institutions aged 20～60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012,622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group,and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group.Questionnaire investigation,chronic occupational stress investigation,physical examination,and laboratory tests were performed for all subjects.Results Compared with the control group,the case group had significantly higher serum levels and abnormal rates of AST and ALT (t=-4.338 and-5.485,x2=11.168 and 34.302,all P＜0.05).There were no significantdifferences in the serum level and abnormal rate of AST between the subgroups with different occupational stresses in both groups (F=2.192 and 2.567,x2=2.694 and 5.402,all P＞0.05),but there were significant differencesbetween the subgroups in all subjects (F=5.005,x2=6.398,all P＜0.05).There were no significant differences in the serum level and abnormal rate of ALT between thesubgroups with different occupational stresses in the case group,the control group,and all subjects (F=0.845,0.450,and 1.416,x2=2.564,1.344,and 3.147,all P＞0.05).The partial correlation analysis showed that the total score of occupational stress was positively correlated withthe serum level of AST (r=0.071,P＜0.05) and was not correlatcd with the serum level of ALT(r=-0.044,P＞0.05),and that the serum level of AST was positively correlated with that of ALT (r=0.736,P＜0.05).After the adjustment for age,sex,nationality,smoking,drinking,marital status,and degree of education,the total score of occupational stress was positively correlated with the serum level of AST (r=0.069,P＜0.05) and was not correlated with the serum level of ALT (r=-0.042,P＞0.05),and the serum level of AST was positively correlated with that of ALT(r=0.730,P＜0.05).The multiple linear regression analysis showed that the serum level of AST increased with the increasing occupational stress (b=0.131,P=0.013).Conclusion Occupational stress is associated with increased serum level of AST,and the serum level of AST increases with the increasing occupational stress.Increased risk of metabolic syndrome caused by occupational stress may be associated with the increased activity of AST caused by occupational stress.

Objective To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome.Methods A case-control study was performed.According to inclusion and exclusion criteria,among the staff members of enterprises and public institutions aged 20～60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012,622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group,and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group.Questionnaire investigation,chronic occupational stress investigation,physical examination,and laboratory tests were performed for all subjects.Results Compared with the control group,the case group had significantly higher serum levels and abnormal rates of AST and ALT (t=-4.338 and-5.485,x2=11.168 and 34.302,all P＜0.05).There were no significantdifferences in the serum level and abnormal rate of AST between the subgroups with different occupational stresses in both groups (F=2.192 and 2.567,x2=2.694 and 5.402,all P＞0.05),but there were significant differencesbetween the subgroups in all subjects (F=5.005,x2=6.398,all P＜0.05).There were no significant differences in the serum level and abnormal rate of ALT between thesubgroups with different occupational stresses in the case group,the control group,and all subjects (F=0.845,0.450,and 1.416,x2=2.564,1.344,and 3.147,all P＞0.05).The partial correlation analysis showed that the total score of occupational stress was positively correlated withthe serum level of AST (r=0.071,P＜0.05) and was not correlatcd with the serum level of ALT(r=-0.044,P＞0.05),and that the serum level of AST was positively correlated with that of ALT (r=0.736,P＜0.05).After the adjustment for age,sex,nationality,smoking,drinking,marital status,and degree of education,the total score of occupational stress was positively correlated with the serum level of AST (r=0.069,P＜0.05) and was not correlated with the serum level of ALT (r=-0.042,P＞0.05),and the serum level of AST was positively correlated with that of ALT(r=0.730,P＜0.05).The multiple linear regression analysis showed that the serum level of AST increased with the increasing occupational stress (b=0.131,P=0.013).Conclusion Occupational stress is associated with increased serum level of AST,and the serum level of AST increases with the increasing occupational stress.Increased risk of metabolic syndrome caused by occupational stress may be associated with the increased activity of AST caused by occupational stress.

Objective:To observe any effect of tactile vibration feedback training on the balance and wal-king ability of stroke survivors.Methods:Fifty stroke survivors who met the selection criteria were randomly divided into a control group ( n=25) and an observation group ( n=25). In addition to conventional exercise training, neuromuscular electrical stimulation and biofeedback therapy, the control group underwent one hour of walking training daily, 5 days a week for 6 weeks, while the observation group received tactile vibration feedback training with the same timetable. Before and after the treatment, lower limb motor function was evaluated using the Berg Balance Scale (BBS), the Timed Up and Go (TUG) test and the Fugl-Meyer lower extremity assessment (FMA-LE). A Gaitrite analyzer recorded the gait parameters of the two groups. The step length on the unaffected side was recorded and the duration of the single support phase was compared between the affected and healthy sides. Results:Before the treatment, there was no significant difference between the two groups in average step length on the unaffected side or in the difference in duration of the single support phase between the affected and healthy sides. The average BBS scores, TUG test times and FMA-LE scores also were not significantly different. After the treatment all of those indicators were significantly better in the treatment group, on average.Conclusions:Tactile vibration feedback training can significantly improve the balance and walking ability of stroke survivors during the recovery period, and lower their risks of falling.

Objective To explore the value of multimodal MRI in evaluating the efficacy of retinoblastoma(RB)after selective ophthalmic artery infusion(SOAI)in children.Methods The MRI and clinical data of 80 children with intraocular RB with monocu-lar disease after chemotherapy were collected.The changes of MRI parameters in children with successful and failed eye protection before and after chemotherapy was analyzed.Results After chemotherapy,the maximum tumor diameter and △ SI were significantly reduced,the distance between tumor and optic disc and apparent diffusion coefficient(ADC)were significantly increased,the calcifi-cation/tumor ratio was increased,and the change of eyeball size was not obvious in the children with successful eye protection com-pared with before treatment.After chemotherapy,the maximum tumor diameter and the range of retinal detachment were significantly increased,and the cross-sectional area of the eyeball was significantly reduced,and △ SI,ADC and calcification/tumor ratio were not significantly changed compared with before treatment in the children with failed eye protection.Conclusion Multimodal MRI can accu-rately evaluate the effectiveness of chemotherapy in children and provide conclusive evidence for the formulation of subsequent treat-ment plans.

Objective:Diabetic retinopathy (DR) is the most common cause of adult blindness in China. Screening of DR is important for early detection, prevention, and treatment. However, there is still controversy in the research on the prevalence and risk factors of DR in China. This study was designed to evaluate the prevalence of DR and related risk factors in patients with type 2 diabetes mellitus in Beijing City.Methods:A cross-sectional survey was conducted in in Dongcheng District and Tongzhou District, Beijing City. Patients with type 2 diabetes aged 18-80 years were selected from four communities, and all subjects underwent questionnaires, physical examinations, laboratory examinations and fundus photography. The logistic regression model was used to analyze the associated factors of DR.Results:A total of 1 531 subjects were included, with the median age of 66 years old and the average age of (65.6±7.4) years old, and the glycosylated hemoglobin level in the subjects was 7.2%±1.3%, and the glycosylated hemoglobin compliance rate was 56.0%(857/1 531). A total of 254 patients with diabetic retinopathy were detected, and the prevalence of DR was 16.6%(254/1 531). Among them, there were 218 cases of non-proliferative diabetic retinopathy and 36 cases of proliferative diabetic retinopathy. Compared with the non-DR group, there were statistically significant differences in fasting blood glucose ( Z=-3.74, P<0.001), glycosylated hemoglobin( Z=-10.664, P<0.001), urinary microalbumin excretion rate( Z=-7.767, P<0.001), low-density lipoprotein cholesterol( Z=-2.589, P=0.01), and duration of diabetes( Z=-10.189, P<0.001) between the DR group and the non-DR group. Multivariate regression analysis showed that the duration of diabetes ( OR=1.08, 95% CI: 1.06-1.10, P<0.001), glycosylated hemoglobin ( OR=1.38, 95% CI: 1.23-1.55, P<0.001), and FPG ( OR=1.11, 95% CI: 1.03-1.19, P=0.008) were associated factors for DR. Conclusion:In this study, the prevalence of DR in 4 communities of type 2 diabetes in Beijing City was 16.6%. Besides, this study further confirmed that the duration of diabetes, fasting blood glucose levels, and glycosylated hemoglobin are associated factors for DR in patients with type 2 diabetes.

Background/Aims: To evaluate temporal trends of atrial fibrillation (AF) prevalence in critically ill patients who received prolonged mechanical ventilation (MV) in the United States. Methods: We used the 2008 to 2014 National Inpatient Sample to compute the weighted prevalence of AF among hospitalized adult patients on prolonged MV. We used multivariable-adjusted models to evaluate the association of AF with clinical factors, in-hospital mortality, hospitalization cost, and length of stay (LOS). Results: We identified 2,578,165 patients who received prolonged MV (21.27% of AF patients). The prevalence of AF increased from 14.63% in 2008 to 24.43% in 2014 (p for trend < 0.0001). Amongst different phenotypes of critically ill patients, the prevalence of AF increased in patients with severe sepsis, asthma exacerbation, congestive heart failure exacerbation, acute stroke, and cardiac arrest. Older age, male sex, white race, medicare access, higher income, urban teaching hospital setting, and Western region were associated with a higher prevalence of AF. AF in critical illness was a risk factor for in-hospital death (odds ratio, 1.13; 95% confidence interval, 1.11 to 1.15), but in-hospital mortality in critically ill patients with AF decreased from 11.6% to 8.3%. AF was linked to prolonged LOS (2%, p < 0.0001) and high hospitalization cost (4%, p < 0.0001). LOS (–1%, p < 0.0001) and hospitalization cost (–4%, p < 0.0001) decreased yearly. Conclusions The prevalence of comorbid AF is increasing, particularly in older patients. AF may lead to poorer prognosis, and high-quality intensive care is imperative for this population.

Objective To investigate the causes of abnormal decrease in maximum amplitude(MA)of thromboelastog-raphy(TEG)and its effect on prognosis by monitoring the changes of coagulation-related indexes in emergency trauma pa-tients.Methods A total of 319 cases of trauma patients admitted to our hospital from September 2020 to September 2023 were retrospectively analyzed,and the coagulation-related indexes of 0 h and 24 h after admission were observed.According to the MA results,they were divided into normal MA group(>50 mm)and reduced MA group(≤50 mm)to compare the hemoglobin(Hb),platelets count(Plt),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(Fib),thrombin time(TT),D-dimer(D-D),coagulation reaction time(R),clot formation kinetics(Angle),30 min clot dissolution rate(Ly30),MA,thrombine-antithrombin complex(TAT)and plasminase-α2 plasminase inhibitor complex(PIC).The correlation between MA and fibrinolysis indexes in 319 trauma patients was analyzed.According to whether tranexamic acid(TXA)was used,the reduced MA group was divided into a TXA group and a non-drug group.The differ-ences in the change of the above coagulation-related indexes,mortality rate and changes in blood product dosage were com-pared between the two groups.Results Compared with the normal MA group,Hb,Plt,Fib,diastolic blood pressure and GCS scores decreased,while heart rate,ISS score and mortality increased significantly in the reduced MA group(P<0.05).The R,PT and TT were prolonged significantly(P<0.05),and PIC and D-D increased significantly(P<0.05)in the re-duced MA group.Correlation analysis found that MA had no correlation with Ly30,TAT and APTT,but was correlated with Angle(r=0.803),Plt(r=0.544),Fib(r=0.581),PIC(r=-0.443)and D-D(r=-0.343).Compared with the non-drug group,the change of Angle,MA and FIB in the TXA group increased significantly(P<0.05),while the change of PIC de-creased(P<0.05).Cryoprecipitate and platelet transfusion in the TXA group reduced significantly(P<0.05),and red blood cell transfusion had a decreasing trend,but the difference was not significant(P>0.05).The mortality rate in the TXA group was reduced significantly(P<0.05).Conclusion Hyperfibrinolysis may be an important factor in the abnormal decrease of MA in emergency trauma patients.Treatment with TXA can improve its effect on MA,and reduce the transfusion of blood products and the patient mortality.