1.Microstructure characteristics of antrum gastritis by using magnified narrow band imaging
Hong LIU ; Bingxia GAO ; Xiangchun LIN ; Nan WEI ; Fangxun LIU ; Jing WU
Chinese Journal of Digestive Endoscopy 2012;29(5):268-271
ObjectiveTo determine the features of antrum gastritis by magnified narrow band imaging (M-NBI) and to evaluate the feasibility of target biopsy with M-NBI.MethodsA total of 69 consecutive patients who underwent M-NBI were recruited in the study.The gastric mucosa of antrum was observed under M-NBI and the gastric microstructure patterns were classified into 5 type.M-NBI findings were compared with the conventional histological findings.In addition,the interobserver agreement was assessed.ResultsA total of 173 gastric antral sites from 69 patients were examined by M-NBI.Type A was mainly normal sites (89.8%,44/49),while type B and C were chronic inflammation (53.3%,24/45 )and active inflammation (74.3%,26/35).Compared with the type A group,the inflammatory degree in type B (P<0.001 ) group and type C group (P<0.001) was significantly higher.The sensitivity,specificity,accuracy of the type B and type C pattern for predicting antrum gastritis were 87.5%,78.0% and 81.5%.The sensitivity,specificity,accuracy of the type D and type E pattern for predicting intestinal metaplasia of antrum were 83.8%,90.4% and 77.5%,respectively.The kappa value for the interobserver agreement was 0.734 [ 95% CI(0.591-0.977 ) ].ConclusionMicrostructure features of antrum gastritis determined by M-NBI are highly correlated with histopathology,and can evidently help diagnosis.
2.An analysis of seven cases of intestinal lymphangiectasia complicated by portal vein hypertension
Fangxun LIU ; Yuguang SUN ; Song XIA ; Xiangchun LIN ; Wenbin SHEN ; Jing WU
Chinese Journal of Digestion 2013;33(4):244-247
Objective To investigate the incidence,diagnosis,treatment and prognosis of abnormal lymphatic vessels in intestinal lymphangiectasia (IL) patients complicated by portal vein hypertension.Methods General information,clinical manifestations,laboratory tests,endoscopy and pathological examination,the results of direct and nuclide lymphangiography,treatment and prognosis of seven IL patients complicated by portal vein hypertension were retrospective analyzed.Results Among seven IL patients complicated by portal vein hypertension,there were five cases with abnormal lymphatic vessels and two cases were merely secondary to portal vein hypertension.The main symptoms were edema,abdominal distension and diarrhea.The results of laboratory tests mainly were lymphocytopenia (0.3× 109 to 1.7 × 109/L),hypoalbuminemia (16.0 to 27.8g/L) and hypoglobulinemia (13.2 to 17.7 g/L).Under endoscope,mucosal edema,chronic inflammatory reaction,intestinal villi spot and patched white nodular changes and polyp-like changes appeared.For treatment,the low-fat with medium-chain triglyceride diet and symptomatic support was the basic treatment.The condition could be relieved by surgical remission of abnormal lymphatic vessels or partial small-bowel resection.If the etiological factors could not be removed,the therapeutic effect was poor in the patients merely secondary to portal vein hypertension.Conclusion The suspicious IL patients complicated by portal vein hypertension need further examination to explore whether abnormal lymphatic vessels existed,and to provide evidence for surgical intervention.
3.Effect of Dietary Zinc Deficiency on Proliferation of Esophageal Squamous Cells in Mice and Related Mechanism
Yao CHEN ; Fangxun LIU ; Chunguang HAN
Cancer Research on Prevention and Treatment 2021;48(5):441-444
Objective To investigate the effect of dietary zinc deficiency on the proliferation of esophageal epithelial cells in mice and related mechanism. Methods Twenty C57BL/6 mice were randomly divided into two groups and fed with zinc-sufficient diet and zinc-deficient diet respectively. We observed the changes of body weight, zinc concentration in blood and tissues, and the expression of PCNA, P38MAPK, NF-κB p105, NF-κB p65 and COX-2 proteins in the esophageal mucosa tissues. Results Compared with the zinc-sufficient group, the body weight and zinc content in blood and esophageal mucosa were significantly decreased in the zinc-deficient group (