Objective To understand the phenotype and enzyme genotype of pan‐drug resistant carbapenemase‐producing Acine‐tobacter baumannii to provide the evidence for clinical rational use of antibiotics and monitoring hospital infection .Methods A total of 117 clinically isolated strains of Acinetobacter baumannii were collected and performed the routine microbiological detection . Multi‐drug resistant Acinetobacter baumannii was screened by K‐B disk diffusion method .The phenotype of carbapenemase‐produ‐cing strains was detected by using the Carba NP colorimetry and modified Hodge test .The drug resistant genotype of multi‐drug re‐sistant Acinetobacter baumannii was verified by PCR .Results Among clinically isolated 117 strains of Acinetobacter baumannii ,64 strains were multi‐drug resistant Acinetobacter baumannii ,in which 33 strains were carbapenemase positive .OXA‐23 drug‐resistant genotype of carbapenemase was detected by PCR ,while IMP ,VIM and NDM‐1 drug resistant genes were not detected .Conclusion The CarbaNP method can rapidly detect carbapenemase‐producing strains with the advantages of strong sensitivity and simple oper‐ation ,which conduces to improve the detection rate of carbapenemase‐producing strains and monitor the nosocomial infection .

Over the past decades, due to the increasing incidence of breast cancers and the rapid advances achieved in biomaterials science, a variety of biological and synthetic meshes have been developed for implant-based breast reconstruction immediately after mastectomy. The mesh-based procedure of breast reconstruction simplifies surgical procedures, reduces postoperative complications, and improves the aesthetic outcomes. We have systematically searched 8 medical literature databases on the complications of breast reconstruction immediately after mastectomy with the use of biological or synthetic meshes in support of prosthetic implants or tissue expanders. This review included a total of 86 clinical studies that met the screening criteria and were published from 2005 to 2021. We reviewed the incidences of major and overall postoperative complications over 12 months or longer in a total of 17 798 breast reconstructions, which were over 10% and 30%, respectively. Major postoperative complications included implant exposure and extraction, dehiscence and skin necrosis, infection, hematoma and seroma, which account for more than 75% of all major postoperative adverse events. There were considerable differences in the incidences of major postoperative complications between biological meshes and synthetic meshes. The use of biological meshes is associated with higher rates of dehiscence and skin necrosis, whereas the use of synthetic meshes is associated with higher rates of implant exposure and extraction. Therefore, besides the selection of proper meshes, surgeons are expected to pay more attention to the prevention and treatment of major complications.

Over the past decades, due to the increasing incidence of breast cancers and the rapid advances achieved in biomaterials science, a variety of biological and synthetic meshes have been developed for implant-based breast reconstruction immediately after mastectomy. The mesh-based procedure of breast reconstruction simplifies surgical procedures, reduces postoperative complications, and improves the aesthetic outcomes. We have systematically searched 8 medical literature databases on the complications of breast reconstruction immediately after mastectomy with the use of biological or synthetic meshes in support of prosthetic implants or tissue expanders. This review included a total of 86 clinical studies that met the screening criteria and were published from 2005 to 2021. We reviewed the incidences of major and overall postoperative complications over 12 months or longer in a total of 17 798 breast reconstructions, which were over 10% and 30%, respectively. Major postoperative complications included implant exposure and extraction, dehiscence and skin necrosis, infection, hematoma and seroma, which account for more than 75% of all major postoperative adverse events. There were considerable differences in the incidences of major postoperative complications between biological meshes and synthetic meshes. The use of biological meshes is associated with higher rates of dehiscence and skin necrosis, whereas the use of synthetic meshes is associated with higher rates of implant exposure and extraction. Therefore, besides the selection of proper meshes, surgeons are expected to pay more attention to the prevention and treatment of major complications.