Objective To explore the changes in intestinal barrier function in college students with exercise-induced gastrointestinal syndrome(EIGS)for searching the related medical monitoring methods.Methods Twenty four college students underwent a six-day endurance training.Their blood D-lactic acid,lipid polysaccharide(LPS),and the activity of diamine oxidase(DAO) were tested before and after the training.Results (1) Blood D-lactic acid,LPS,and the activity of DAO increased significantly in 7 subjects with EIGS comparing to their baseline values(P<0.05):(2)The level of D-lactic acid,LPS,and the activity of DAO in the 7 subjects with EIGS were significantly higher than in those without EIGS(P<0.05).Conclusion The level of blood D-lactic acid,the content of lipid polysaccharide,and the activity of the diamine oxidase are closely related to the intestinal barrier function,and thus can be used as indicators for monitoring the stomach-intestine function during trsinjng.