Objective As economy in China growing fast, it will in turn bring changes on the status of genitourinary cancer inpatients. Methods A survey has been made of urological inpatients from January 1951 to December 2000 in the Institute of Urology of Peking University to find the changing status of genitourinary cancer in the recent 50 years. Results From January 1951 to December 2000, there were 28 521 urological inpatients. The cancer patient in the first and second 25 years constituted 19.5% and 28.2% respectively. Since 1970s renal cancer and prostate cancer increased dramatically from 10.4% to 28.7% and 3.3% to 13.4% respectively. Conclusions The introduction of new diagnostic techniques, the expansion of the aged population and a high fat diet are considered to be responsible for this change.

Objective To evaluate the diagnosis and treatment of transitional cell carcinoma of the bladder in patients under 30 years of age. Methods A retrospective study of 22 cases of transitional cell carcinoma of bladder in patients under 30 years of age treated between 1980 and 1999 was carried out. Results In most patients evaluation was prompted by gross hematuria(77.3%).Preoperative B-ultrasonography and urinary cytology correlated well with cystoscopic and biopsy findings.18 cases were treated by means of transurethral resection, and 4 cases by partial resection of bladder. 17 patients have been followed up for 6～107 months.5 patients had recurred. Conclusions Transitional cell carcinoma of the bladder ocurrs rarely during the first three decades of life. The tumors were of low grade,noninvasive,and associa- ted with a low recurrence and an excellent prognosis. The treatment of choice is transurethral resection. Regular follow-up is essential.

OBJECTIVETo assess the changes in constituents of genitourinary cancer inpatients in Beijing following the growing economy of China.

METHODSUrological inpatients treated from January 1951 to December 2000 at the Institute of Urology, Peking University were studied retrospectively.

RESULTSIn the period of about 50 years 28 474 urological inpatients were reviewed. Cancer patients in 1951-1965 and 1966-2000 comprised 19.5% and 28.2%, respectively [corrected]. Since the 1970s the incidence rates of renal cancer and prostate cancer increased dramatically from 10.4% to 28.7% and from 3.3% to 13.4%, respectively.

CONCLUSIONThe introduction of new diagnostic instruments, the expansion of the aged population and a high fat diet are considered to be responsible for the change of constituents of genitourinary cancer inpatients.

Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; China ; epidemiology ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Retrospective Studies ; Urogenital Neoplasms ; epidemiology

Objective To explore the application of monoclonal antibody (McAb) to targeted treatment of bladder carcinoma through a series of in vitro and in vivo studies carried out in animal model and patients with bladder carcinoma.Methods Monoclonal antibody BDI-1 against bladder carcinoma was prepared by the lymphocyte hybridoma technique. McAb was conjugated with 99m Tc by direct reduction method. Momodin (MD) was covalently linked to McAb by SPDP method. Radioimmunoimaging of nude mice xenografts and patients with bladder carcinoma were performed with BDI-1-99mTc conjugates. An immunotoxin (BDI-1-MD) was inducted via a catheter into the bladder. Targeted treatment with BDI-1-MD was carried out in 18 patients.Results This study showed the specificity of McAb, and clear imaging of nude mice bearing xenografts. Distribution analysis of 99m Tc-BDI-1 in nude mice showed the highest value of T/NT in bladder tumor. Targeted diagnosis and treatment for patients by intravesical administration are very safe and effective.Conclusion The bladder cancer seems an ideal model for diagnostic and therapeutic approaches using regional administration of McAb conjugates via a catheter direct into the bladder.