AIM: To study the effect of local application of indomethacin on acute pulpitis. METHODS: Traumatic pulpitis model in rats was established by means of pulp exposure, radioimmunoassay (RIA) was used to measure the kinetic changes of the levels of PGE_2、6-keto-PGF_~1? and TXB_2 of pulpal tissues. RESULTS: Local application of indomethacin could more effectively inhibit the cyclo-oxygenase pathway than zinc oxide engenol in the early stage of pulpitis and reduce the production of prostaglandins. CONCLUSION: Local application of indomethacin may have a therapeutic effect on acute pulpitis. [

AIM: The purpose of this study was to eva lu ate the effect of tetracycline combined with anti-inflammation drug on the serum antibody level against porphyromonas gingivalis (Pg) in patients with early-ons et periodontitis (EOP). METHODS: The study population consisted of 12 individuals with e arly-onset periodontitis, 16 patients with adult periodontitis (AP) and 12 perio dontally healthy subjects (HS). Clinical examination and recordings of probing p ocket depth (PPD), periodontal attachment level (PAL) and bleeding on probing (B OP) were performed prior to treatment and at three months following the periodontal treatment. The serum antibody titer against Pg in patients with EOP was measured at diagnosis and at the termination of treatmeat. RESULTS: A significant improvement was observed in probing pocke t depth, periodontal attachment level and gingival bleeding index post treatment for three months. The serum IgG antibody titer against porphyromonas ging ivalis was decreased significantly after the treatment. CONCLUSION: Our results demonstrate that mechanical periodontal treatment combined with tetracycline and anti-inflammation drug provides clinica lly favorable results in patients with early-onset periodontitis.