AIM: To study the preventive and cure effects of the guizhi fuling pellet (GFP) on rat hysteromyoma modes. METHODS: Estradiol (0.2) mg per rat was administrated by subcutaneous injection once a day to establish rat hysteromyoma model. (0.8) (mg?kg~(-1)) adrenalin was administrated by subcutaneous injection to establish rat blood stasis model. RESULTS: GFP((1.08)-(4.32) (g?kg~(-1)))remarkably decreased uterus weight, restrained the excess proliferation of the smooth muscle of uterus, decreased the estradiol and progesterone in blood serum, restrained the platelet aggregation, and it significantly decreased the blood viscosity, prolonged blood coagulation time, kaolin partly theroboplastin time and prothrombin time of rats. CONCLUSION: GFP can restrain the formation of hysteromyoma, and the mechanism of GFP is related to decreasing the estrogen and progesterone, activating blood circulation to dissipate blood stasis.