Objective To observe the effect of actovegin on diabetic peripheral neurapathy (DPN).Methods 76 patients with DPN were divided into treatment and control groups at random.Two groups were treated routinely with general treatment on DM and the treatment group was added routine dose of actovegin while the control group were treated with Methycobal.After 8 weeks,the effective rate,MCV and SCV were determined.Results The general effective rate and MCV and SCV in treatment group were higher markedly than control group.Conclusion Actovegin can improve DPN effectively.

Objective To observe the clinical effect of hyaluronic acid on conception rate of ectopic pregnancy patients who received conservative tubal operation under laparoscopy.Methods 100 patients with ectopic pregnancy received conservative tubal operation under laparoscopy treatment were selected.Hyaluronic acid was used in 50 cases (the treatment group),unused anti blocking preparations for the control group in 50 cases.Then patients were followed up on the tubal patency,and observed pregnancy after 1 year.Results The rate of tubal patency after menstrual clean was 84％ in the treatment group,which was significantly higher than 60％ in the control group(x2 =7.155,P ＜ 0.05).In the treatment group,40 cases were intrauterine pregnancy,4 cases were ectopic pregnancy,6 cases were infertility.The rate of intrauterine pregnancy after 1 year was 80％ in the treatment group,which was significantly higher than 56％ in the control group(x2 =6.65,P ＜ 0.05).Conclusion Hyaluronic acid is effective in preventing tubal adhesion in the ectopic pregnancy patients who received laparoscopic conservative surgery,and can improve the postoperative tubal patency rate and conception rate.

Objective] To study emotional counterbalance therapy which is used in depression treatment ,it plays an important role in the treatment of emotional disorders. [Method] With the research methods of taking depression for example ,through the sad,fear of these two emotional factors to explore the pathogenesis of depression,and analyze“happiness restrains sadness“ and“thought restrains fear”in the emotional counterbalance therapy, which are used in the depression clinical application.[Result]Emotional counterbalance uses one or more of the emotions to regulate ,control,overcome the other one or more negative emotions,which based on the restriction among the five elements theory is a kind of psychological therapy.Sadandfearare the most common chief complaints in depression which belong to the emotional depression in depression disease of Chinese medicine. On the basis of “sad doing harm to the lungs”and “dread doing harm to the kidneys”,lung,kidney and depression etiology,pathogenesis,symptoms are closely related. This reflects the lung,kidney play an indispensable role in the treatment of depression. It has significant curative effects to apply the theory of emotion counterbalance,such as happiness restrains sadness,thought restrains fear to cure diseases. At the same time,with a relaxed and pleasant mood,actively guiding to help thinking is also the treatment of depression,pessimistic disappointment medicine.[Conclusion] According to the restriction among five elements theory,to use the relation and restriction between emotion and five zang-organs to regulate emotional disorders can restore to the normal balance,which is an effective psychological treatment for emotional disorders.The therapy should be used alone or combined with traditional Chinese medicine treatment in different situations to relive the treatment effect.

This paper construct an evaluation index system for performance appraisal of public hospitals financial governance,using the meta-analysis,expert panel discussion and Delphi method.With two rounds of expert consultation and panel discussion,such an evaluation index system was completed,comprising 6 primary dimensions,15 secondary dimensions and 48 evaluation indexes.

Objective To observe the clinical efficacy of esomeprazole combined with trimebutine maleate in the treatment of reflux esophagitis patients without helicobacter pylori infection.Methods 78 patients with reflux esophagitis were randomly divided into two groups,46 patients in study group and 32 patients in control group.30 minutes before the breakfast,all the patients took Nexium 20mg,twice a day.The study group was given trimebutine maleate 200mg,thrice a day additionally.The treatment course was 4 weeks.The effect and the result of gastroendoscopy were observed.Results The average time of clinical symptoms disappeared in study group was (10.51 ± 2.43) days,which was significantly shorter than (12.31 ± 3.17) days of the control group (t-2.84,P ＜ 0.01).The total effective rate of the study group was 97.83％,which was significantly higher than 81.25％ of the control group (x2 =4.48,P ＜ 0.05).Conclusion Esomeprazole combined with trimebutine maleate in the treatment of reflux esophagitis without helicobacter pylori infection can promote gastric emptying,prevent reflux,control esophageal inflammation and promote ulcer healing effectively.

Objective To understand the influence of operation to quality of life by evaluating the QoL of the patients with rectal cancer, before and after the Miles' operation. Methods To select 57 patients received Miles operation. To evaluate the quality of life of the 57 sample patients that before Miles' operation and the first, the sixth, the twelfth month after the operation by using the QoL evaluation sheet. Results The QoL score of the rectal cancer patients after operation is obviously lower than that before operation [(89.24±10.62) vs (106.32±11.2.9, P<0.01]; the QoL scores the 12th month after operation is obviously higher than before operation [(114.05±8.20) vs (106.32±11.29), P<0.05]. Conclusion The recent QoL of the patients with rectal caucer after Miles' operation was descents obviously, but the long-term QoL of the patients after operation promotes obviously.

0.05).③ HDF feeder layer could improve the efficient growth of primary keratinocyte culture plated at very low seeding densities (0.1? 104 cells/cm2). Conclusions Different allogenic keratinocytes can grow in HDF feeder layers from various passages of the same HDF line. HDF feeder layer is able to improve the seeding efficacy of human keratinocytes, which may be the reason te culture plated at very low seeding

Objective To investigate the role of p38 mitogan-activated protein kinase signal transduction pathway in lipopolysaccha-ricle-indaced acute lung injury (ALI) in rats. Methods 48 wistar rats were randomly divided into 3 groups, saline control group (group A), lipopolysaccharide (LPS) group(group B) and SB203580 group(group C). Models of lipepelysaccharide-imluced ALI were used to oh-serve the expression of p38MAPK in rat lung, protein content, the ratio of neutrophiles in bronchoalveolar lavage fluid (BALF) , pulmonary MDA content and the activities of serum NO. After LPS dripping for 6 hours, arterial blood was drawn for analysis and lung tissue was detec-ted. Results Compared with those in group A, expression of p38MAPK were markedly increased in group B and C (P<0.01). But in group C, expression of P38MAPK was significantly lower than that in group B (P<0.05). The protein content, the ratio of neutrophiles in bronchoalveolar lavage fluid (BALF), content of pulmonary MDA and the activities of serum NO in group B, C were significantly higher than those in group A (P<0.01). There was a significant decrease in the level of arterial bicarbonate and partial pressure of oxygen in group B and C (P<0.01). Compared with those in group B, these indexes of lung injury were significantly lower while the level of arterial bicar-bonate and partial pressure of oxygen was increased in group C(P <0. 05 orP <0. 01). Under light microscope, the pathologic changes in-duced by LPS were significantly attenuated by SB2035g0. Conclusion The activation of P38MAPK play an important role in the mechanism of lipopolysaccharide-induced ALI.

Objective To investigate the effect of radix paeoniae rubra (RPR) on expressions of p38MAPK, NF-κB and iNOS in ltpopolysaccharide (LPS)-induced acute lung injury (ALI) and explore its protective mechanism. Methods Forty Wistar rats with ALI were divided randomly into five groups: saline control group (Group A) , LPS group (Group B), RPR for treatment group (Group C), RPR for prevention group (Group D) and SB203580 group (Group E). The effects of RPR on protein content and the ratio of neutrophiles in bronchoalveolar lavage fluid (BALF), contents of malondidehyde (MDA) and serum NO in lung tissue were observed. Arterial blood was collected for blood gas analysis. Expressions of p38MAPK, NF-κB and iNOS in rat lung tissues were detected. Results Compared with Group A, expressions of p38MAPK, NF-κB and iNOS were significantly increased (P <0.01 orP< 0.05) , the protein content and the ratio of neutrophiles in BALF, contents of MDA and serum NO were significantly higher (P<0.01 or P<0.05) in Groups B, C, D and E. There was a significant decrease in the level of arterial bicarbonate and partial pressure of oxygen in Groups B, C, D and E (P<0.01 or P<0.05). Compared with Group B, the expressions of p38MAPK, NF-κB and iNOS were significantly lower, and the protein content and the ratio of neutrophiles in BALF, contents of MDA and serum NO were significantly decreased, while the levels of arterial bicarbonate and partial pressure of oxygen were significantly higher in Groups C, D and E (P<0.05 or P<0.01). Compared with Group B, the lunginjury of Groups C, D and E was significantly alleviated, while there was no statistical difference among Groups C, D and E in the indices of lung injury. Conclusion Protective effect of RPR on LPS-induced ALI is closely related to the inhibited expressions of p38MAPK, NF-κB and iNOS.

Objective To investigate the differences in the inhibition of return (IOR) capacity of attention between expert and novice pilots.Methods Compared the capacity of IOR of 10 expert pilots and 10 novice pilots under the conditions of adjacent and spaced clueing positions by experiment and by means of simultaneous cueing processes.Results These data suggested that in simultaneous cueing processes,no matter that the clueing positions were adjacent or spaced,the reaction time of expert pilots( adjacent:(428.01 ± 64.89) ms,spaced:(425.24 ± 63.94 ) ms) was slower novice pilots ( adjacent:( 363.05 ± 38.95 ) ms,spaced:( 360.61 ± 41.70 ) ms )(P ＜ 0.01 ) ; the capacity of IOR in no matter that the clueing positions were adjacent or spaced.The expert pilots showed IOR at only one location when the 5 clues all appearance in simultaneous cueing processes (P＜ 0.05 ),and no IOR could be see in the other locations.The novice pilots showed IOR when the from 3 to 5 of clues appearance in simultaneous cueing processes,the disparity was significantly predominance(P＜ 0.01 ).Conclusion The expert pilots of stability of capacity of IOR is better than novice pilots,and show solidly and highly efficient space searching ability.