Peroxisome proliferator-activated receptors(PPAR) are ligand-activated nuclear transcription factors which regulate the expression of many genes.Numbers of researchs indicate PPAR exert anti-inflammatory activities by inhibiting the expression of inflammatory singal transcription passage such as NF-?B,AP-1,STAT,meanwhile preserve from acute lung injury.This review will focus on structure of PPAR and their ligand and activity regulation and antiinflammation mechanism of action and protection to acute lung injury.

There are about 170 kinds of medical plants of Commelina all over the world.Experimental studies showed that the main chemical compositions in the plants included alkaloids,flavonoids,terpenes,and sterols etc.Plants of commelina,especially commelina communis,have pharmacological activities of antibacterial,antiinflammation,resisting-oxidation,lowering-glycemia,relieving-pain and stopping-cough etc.It is necessary that their pharmacological effects and chemical compositions are further developed and investigated systematically.

Alport syndrome, characterized by hematuria, renal failure, sensorineural deafness, and ocular abnormalities, is an inherited glomerular disease caused by mutations in the COL4A5 (X-linked), or COL4A3 and COL4A4 (autosomal recessive) genes.The ultrastructural changes of Alport syndrome can be observed in the electron microscopic analysis of renal biopsies, which are characterized by irregular thinning/thickening, layering and splitting dense layer of the glomerular basement membrane.In the basement membrane of skin and renal biopsy tissue, type IV collagen α chain immunofluorescence test can be used to diagnose Alport syndrome, screen the carriers and determine the mode of inheritance.The analysis and detection of Alport syndrome gene are not only useful for genetic counseling, but also useful for identification of gene carriers, prenatal diagnosis, and identification of suspected patients who can not be confirmed by clinical and pathological examination results.

Diffuse large B-cell lymphoma (DLBCL) has a high degree of heterogeneity in clinical manifestations,pathological morphology and genetic features.According to its classification by WHO in 2008 WHO,DLBCL is defined as large B-cell lymphoma with diffuse growth and having nuclei similar with or larger than those of normal macrophages.In recent years,the clinical features,morphology,immunohistochemistry,and even gene expression pattern are integrated for classification of DLBCL.It's a new era to stratify DLBLC by gene expression profile.This article summarized research progress in DLBCL classification based on gene expression profile and immunohistochemistry and its effects on prognosis of DLBCL.

Objective To explore the influence of Dan'e-Fukang soft extract on anxiety and depression of edometriosis patients.Methods 83 patients with endometriosis were randomly divided into a treatment group,treated with Dan'e-Fukang soft extract and a control group,treated with Gesrtinone capsules.Gynecological examination,pelvic B-mode ultrasonopgraphy,liver function,kidney function and CA 125 were detected before and after the treatment.The alteration of dysmenorrhea pain,menstrual blood volume,and adverse reactions were observed.Self-rating Depression Scale (SDS) and self-rating Anxiety Scale (SAS) were used to test the patients after treatment.Results ① Endometriosis effective rate of the treatment group and the control group were 95.35％ and 100.0％ respectively.② SAS and SDS score of the treatment group were (48.56± 5.39) and (50.35 ± 6.76) respectively before treatment,(33.43 ± 4.52) and (35.54± 4.68) respectively after treatment.The score of control group were (46.92±6.35) and (53.41 ±7.00) before treatment (37.56±5.64)and (42.87± 5.79) respectively after treatment.The scores had no significances between the two groups before the treatment,but had significant difference after the treatment(P＜0.05).Conclusion Dan'e-Fukang soft extract has exact effects on endometriosis,and its effects on mood are partly independent from endomet riosis.

On the one hand, diabetes mellitus and psychological diseases can affect each other to bring about many bad consequences, such as insomnia. On the other hand, insomnia can also cause diabetes mellitus and psychological diseases. TCM also has some knowledge on the relations between them. The present paper is a general survey of recent studies on this field in China and abroad.

Objective To evaluate the clinical symptoms,therapy and prognosis of cardiogenic cerebral embolism(CCE).Methods Clinical date of 72 patients with CCE were analyzed.Results 56 cases of CCE were over 60 years old men,which take up 77.8% ;non valvar atrial fibrillation (NVAF) 83.3% ;left medial cerebral arteria embolism 52.8% ;embolism hemorrhagic 19.4% ;death takes up 8.33%.Conclusion Atrial fibrillation is the main cause of the CCE,prognosis of CCE is not good,anticoagulant is an effective treatment for atrial fibrillation patients,it can avoid cerebral embolism.

OBJECTIVE:To evaluate the economic effectiveness of different pharmacotherapeutic schemes for the same disease METHODS:Using retrospective study and pharmacoeconomical cost-effective analysis,five schemes for child virus pneumonia were compared RESULTS:There were no significant differences in efficacy among scheme A,B,C,D and E (X2=3 248,P=0 517) The costs of scheme A,B,C,D and E were 2 457 76,2 446 74,1 642 56,2 062 26 and 1 476 6 yuans and cost-effectiveness ratios obtained by sensitivity analysis were 26 08,30 58,17 67,26 16 and 19 61 respectively CONCLUSI_ON:Pharmacoeconomically,scheme C is the most effective,the safest and the most economical one among five schemes

Objective:To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.Methods: The effects of gastric distention and intravenous CCK on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius were investigated in urethane anesthetized rats.Results:Intravenous CCK could obviously influence the spontaneous activity of gastric distention related neurons in the nucleus of tractus solitarius.Intravenous CCK could increase the discharge of gastric distention(GD)excited neurons(9/14)and decrease the discharge of GD inhibited neurons(5/14) in NTS.Howerer,the effect of CCK on gastric distention-induced discharge of GD related neurons was always inhibitory.Conclusion:Circulating CCK and gastric distention have both excitatory and inhibitory effects on the electricity activity of gastric distention related neurons in NTS,but the effect of CCK on gastric distention-induced discharge of GD related neurons is inhibitory.The effect of gastric distention on spantenous discharge of neurons in NTS is similar to circulating CCK.

Objective:To discuss the clinical value of pelvic devascularlization in prevention and treatment for gynaecology and obstetrics refractory hemorrhage.Methods:To analyze retrospectively the effect of 15 cases of obstetrics,2 cases of preventing hemorrhage,5 cases of gynaecology refractory hemorrhage,all of these are treated by pelvic devascularlization.Results:There are 2 cases of placenta praevia of central type,(hemostatic scrap interdict uterus artery blood flow,volume of hemorrhage