OBJECTIVE:To find out the regulareity of adverse reactions(ADRs)induced by oral Penicillins(QMSK)and evaluate the safety of QMSK in clinical use.METHODS:Data of ADRs of QMSK,which collected from published articles were retrieved from CHINESE PHARMACEUTICAL ABSTRACT issued between January1995and April2003.According to the given standard,the data were statistically analysed.RESULTS:There were334cases which had24kinds of ADRs of QMSK,of which,121cases were male while213cases were female.There were drug eruption in249cases(74.55%),allergic shock34(10.18%),exfoliative dermatitis9(2.7%)and toxic epidermalnecrolysis7(2.1%),miscellaneous reactions31(8.97%)and5(1.5%)deaths.CONCLUSION:QMSK caused ADRs apparently.QMSK should be used according to penicillins for injections and safe of patients should be ensured in use of QMSK.

The core of the ethical and legal issues in the treatment and recovery of patients with mental disorders is the balance between public security and individual interests. In the treatment and recovery of patients with mental disorders, it is imperative to adhere to the principles of respecting basic hmnan rights and respecting the freedom, dignity, equality and rights of the individual, protect the privacy of the patient, stick to the combination of hospital recovery and community recovery, and strictly define the boundary between willing treatment and unwilling treatment. The aim is to promote the recovery and return of patients to society. At the same time, it is necessary to put issues of mental hygiene in China on the demestic legislative agenda and set up a specialized multi-level legal system of mental hygiene.

The authors first give a detailed account of the background against which humanistic medicine came into being and then expound the connotations of humanistic medicine. These include the following aspects. The first one is humanism and the humanistic spirit. The second one is humanistic medicine and the three implications it embodies. The authors argue that humanistic medicine, taken as the science of benevolence, ought to regard the patient as the unity of three aspects, physiological, psychological and social. The third one is medical humanity, viz. medical humanity is indispensable to the advancement from physiological medicine to humanistic medicine. As to what disciplines are involved in medical humanity, no final conclusion has yet been reached on this matter so far.

In the new economic situation for the new requirements for traditional Chinese medicine innovation talents cultivation, in view of the relevant medical education at home and abroad experience and many years of exploration in our school, we suggest that in the curriculum construction and development of the national institutions of higher learning of Chinese medicine, the experiment teaching of traditional Chinese medicine should be extended by popularizing college students' exploring experiment and innovative experiment and establishing the combined mechanism between the excel-lent students and excellent teachers. We also put emphasis on developing five abilities, which include the ability of structuring own knowledge system, the ability of acquiring useful knowledge and aban-doning other, the ability of logical reasoning and critical thinking skills, the ability of professional in-terest and innovation, and the ability of expressing themselves and communication skills.

Targeted therapy is the most prospective part of the research related to the treatment of non-small cell lung cancer(NSCLC). After epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase (ALK)gene is expected to become a new target in the treatment of NSCLC. Moreover,several related resear-ches suggest that ALK inhibitor(crizotinib)is effective for treatment of ALK-rearranged NSCLC. Therefore,it is important to review the detection method of ALK gene,clinicopathologic features and the research progress of ALK inhibitor for the individual treatment of NSCLC.

This paper describes the biological characteristics of human and mouse adrenal cortical carcinoma cell lines and presents research progress made in rat and bovine primary cultured adrenal cortical cells.The effect of angiotensin Ⅱ,potassium,adrenocorticotropic hormone and cAMPon different adrenal cortical cell lines were compared and analyzed,regarding the differences of steroid hormone secreted.The article suggests that it is necessary to develop and establish some ideal adrenal cortex cell models for furtherstudying the mechanisms of steroid hormone synthesis and secretion.

Objective To investigate the localization and distribution of the five endocrine cells in the digestive tract mucosa of ricefield eel(Monopterus albus). Methods Using immunocytochemical technique of strept avidin-biotin-peroxidase complex(SABC) were used. Results At least 5 kinds of immunoreactive endocrine cells distributed in the digestive tract mucosa of M.albus. They were gastrin(Gas),somatostatin(Som),5-hydroxytryptamine(5-HT),insulin(Ins),and neurofilament (NF) immunoreactive endocrine(IRE) cells.Gas and Som-IRE cells distributed between stratified squamous epithelium and goblet cell in esophagus. A large number of Gas-IRE cells were found between gastric fundus epithelium and gastric glands, and only a few in the carcia. Ins, 5-HT and NF-IRE cells distributed in the epithelium pylorus and pyloric glandular tube respectively. No any immunoreactive positive reaction was found in the gut of M.albus.In addition, immunoreactive positive reaction of glucagons was not found in whole digestive tract.All immunoreactive endocrine cells were dark brown in color.Their morphology was irregular, cytoplasmic process was shorter and thicker, their nucleus showed an empty bubble.They distributed between esophageal epithelium and gastric epithelium or glandular epithelium, and cytoplasmic process extended to the gastric lumen and glandular cavity.Conclusion There is a complex endocrine function of the digestive system in ricefield eel (M.albus) at the lowest vertebrate.

Objective To retrospectively evaluate effects of early dynamization of interlocking intramedullary nail on union of tibial shaft fractures.Methods From January 2002 to Septemher 2004,75 patients with tibial shaft fractures were treated in our department with internal fixation using static interlocking iutramedullary nails.Early dy- namization(6 to 10 weeks postoperative)was adopted in 32 patients (the dynamic group) according to the fracture con- ditions,while the other 43 patients were treated without early dynamization (the non-dynamic group).The healing time of fractures and the rate of delayed union in both groups were documented.Results All the cases were followed up for a mean duration of 6.5 months (range,4 to 13 months).The mean healing time was 115.6 days (range,105 to 126 days) in the dynamic group and 124.5 days (range,119 to 133 days) in the non-dynamic group.The difference was statistically significant between the two groups (P＜0.05).There were two cases (6.2%) of delayed union in the dynamic group and four (9.4%) in the non-dynamic group.The difference was not significant (P＞0.05). Conclusion Early dynamization of interlocking intramedullary nail can promote union of tibial shaft fractures.

0.05).Conclusion: Feasibility of galvanic corrosion between Fe-16Cr-2Mo soft magnetic alloy and dental alloys used in clinic application can be omitted.

OBJECTIVE To investigate the clinical features of nosocomial acquired pneumonia in elderly patients with apoplexy.METHODS A retrospective study was carried out to investigate the clinical data of 724 elderly patients with apoplexy in Department of Neurology during Jan 1st,2003 to Dec 31st,2005.RESULTS The nosocomial acquired pneumonia rate was 12.26%.The nosocomial infection rate in patients with cerebral hemorrhage and cerebral infarction was 23.79% and 6.48%,respectively.The incidence rate of nosocomial acquired pneumonia was related positively to long time in hospital,underlying disease severity,consciousness,swallow,preventive antibiotic therapy and diabetes.CONCLUSIONS More attention should be paid in clinical treatment and nursing care in order to lowering the occurrence of the nosocomial acquired pneumonia.