Objective To investigate the influence of Enalapril Maleate Tablets on serum micro inflammatory indexes and nutritional indexes in maintenance hemodialysis patients. Methods A total of 90 patients with chronic renal failure treated by maintenance hemodialysis in our hospital from April 2015 to October 2016 were randomly divided into control group and experimental group, with 45casesin each group. The control group was treated with atorvastatin,andthe observation group was treated with atorvastatin combined with enalaprilmaleate tablets. After treatment,the levels of the inflammatory markers of high sensitive C reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), interleukin 6 (IL-6) and the nutritional index of plasma albumin(ALB), prealbumin(PA) in two groups were analyzed. Results After treatment, the levels ofHS-CRP, TNF-alpha in the observation group were lower than those in control group, the difference was statistically significant (P<0.05); The levels of IL-6, IL-8 in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05). The indexes of ALB and PA in the observation group after treatment were higher than those in the control group, the difference was statistically significant (P<0.05). Conclusion For the patients with maintenance hemodialysis treatment, the clinical effect of using conventional atorvastatin treatment combined with Enalapril Maleate Tablets is good, high safety, with further clinical promotion and application significance.

Autophagy is a physiological process which delivers the mutant cytoplasmic proteins and dysfunctional subcellular organs into lysosomes for degradation to generate fuel in the deficiency conditions. It is mainly classified into macroautophagy, microautophagy and chaperon-mediated autophagy (CMA), as well as the selective autophagy such as mitophagy and aggrephagy. This review mainly introduces the key molecular markers of macroautophagy, CMA and mitophagy.
Autophagy ; Humans ; Lysosomes ; Mitochondrial Degradation ; Molecular Chaperones

Objective To investigate the effect and psychological intervention of the treatment of hemodialysis internal fistula with Hirudoid combined with far infrared ray. Methods 80 cases of hemodialysis fistula were diagnosed and treated from January 2014 to December 2016 in Lishui Central Hospital,according to different treatment intervention methods, which were divided into two groups, each group with 40 cases. The control group was treated with routine nursing and far infrared therapy, and the observation group was treated withpsychological intervention and Hirudoid+far infrared therapy. The clinical efficacy, the improvement of clinical symptoms and the incidence of complications were compared between the 2 groups. Results The clinical effect of the observation group was better than that of the control group, the improvement of the clinical symptoms was better than that of the control group,the complication rate was lower than the control group,the difference was statistically significant (P<0.05). Conclusion The clinical effect of psychological intervention plus Hirudoid+far infrared ray in the treatment of hemodialysis fistula patients is significant,which can effectively improve the clinical symptoms and complications in patients with less, and is worthy of clinical application.

Objective To explore the effects of post-discharge continuous nursing intervention on medication compliance and negative emotion of patients with acute myocardial infarction after percutaneous coronary intervention (PCI).Methods 168 patients with acute myocardial infarction were selected.All of them got emergency PCI after admitted.Then,they were simply randomized into observation group (84 cases) and control group (84 cases) using coin toss method combined with random comparison table.The observation group accepted continuous nursing intervention after discharged,including regular home visits,telephone feedback and clinical visits.The control group got a regular clinical follow-up.Their medication compliance and negative emotion were investigated after 1 month,3 months,6 months and 12 months from discharged,respectively.Results Relevant data with different periods of patients with repeated measurement data analysis of variance,discharge for 3 months,6 months and 1 year,compared with the control group,the medication compliance of the observation group increased obviously,the SAS and SDS scores decreased obviously,the differences were statistically significant (t =1.432,2.781,1.432,2.781,2.504,3.783,2.761,4.621,4.884,all P ＜ 0.05).Further analysis of the data between inter group effect,time effect,inter action effect showed that with the extension of the discharge time,the medication compliance and SAS,SDS scores of the two groups were significantly different (F =30.258,P ＜ 0.01;F =2.673,P ＜ 0.05;F =2.024,P ＜ 0.05).In hospital,there were no statistically significant differences in the quality of life of patients between the two groups(t =1.250,1.250,1.250,1.250,0.694,1.113,2.463,all P ＞ 0.05).1 year after discharge,compared with the control group,the movement and exercise,interpersonal relationships,nutrition,health responsibility,self-actualization,stress management scores in the observation group significantly increased,the differences were statistically significant (t =2.463,3.146,2.463,3.146,2.633,2.115,all P ＜ 0.05).Conclusion Continuous nursing interventions can effectively reduce acute myocardial infarction patients'anxiety and depression after PCI,improve their compliance and prevent recurrent cardiovascular events.

OBJECTIVE To investigate the expression of keratinocyte growth factor(KGF)in middle ear cholesteatoma and to explore the role of KGF on the hyperproliferation of the cholesteatoma epithelium and the formation and development of cholesteatoma. METHODS The specimens from the cholesteatoma tissue of 20 cases and the corresponding normal external ear skin were examined by immunohistochemical S-P method and quantitative analysis. RESULTS In normal ear skin only stroma staining for KGF was positive. In cholesteatoma epithelium staining for KGF was strongly positive and the stroma staining was stronger than that of normal ear skin. The positive rates of the cholesteatoma and normal external ear skin revealed a significant difference. There was a positive correlation between cholesteatoma epithelium staining for KGF and for Ki67 and the coefflcient of correlation was 0.609(P﹤0.01). CONCLUSION There was correlation between the expression of KGF or Ki67 and the ability of reproduction of middle ear cholesteatoma. Local inflammation might promote hyperproliferation of the epithelium of cholesteatoma by regulating the expression of KGF. It suggested that an autocrine stimulation of KGF correlate with the occurrence and development of cholesteatoma .

Objective To explore the effects of patient mutual help-oriented nursing model on social support and hope level in lung cancer patients.Methods Totally 72 lung cancer patients were recruited into the study and divided into the experimental group and the control group with 36 patients in each group.The control group was given routine care,while the experimental group received additional patient mutual help-oriented nursing interventions:physically and psychologically well recovered patients were asked to give emotional communication and interaction to patients newly diagnosed with lung cancer,The Social Support Scale and Herth Hope Index were used for evaluation after the intervention.Results The patients' social support and hope level of the intervention group were significantly better than those of the control group after intervention.Conclusions Patient mutual help-oriented nursing model can improve social support and hope level of lung cancer.

Objective To translate the English version of Career Needs Questionnaires-Short Form (CNQ-SF) into Chinese and to test the reliability and validity of the Chinese version of CNQ-SF in cancer patients.Methods Totally 232 patients with cancer were recruited and were investigated by the Chinese version of CNQ-SF.Results The internal consistency coefficient of the Chinese version of CNQ-SF ranged from 0.792 to 0.937.The content validity index was 0.94.Factor analysis got five factors,which explained 69.8％ of the total variance.Conclusions The Chinese version of CNQ-SF has been proved to be reliable and valid.h can be used as a valid tool for the measurement of information needs of cancer patients.

Objective To investigate the clinical effect of percutaneous balloon angioplasty for the treatment of arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients. Methods Percutaneous balloon angioplasty was performed in 14 hemodialysis patients with arteriovenous fistula stenosis or occlusion in upper extremity. The preoperative and post operative clinical manifestations, the color Doppler ultrasonographic findings, the blood flow during hemodialysis and the angiographic demonstrations were recorded and compared. Results After balloon dilatation, the constricted segment was remarkably dilated and the occluded site was re-opened in all patients. Angiographic findings showed that the degree of stenosis was less than 30%. Conclusion As a simple, mini-mvasive and safe technique with remarkable short-term effectiveness, percutaneous balloon angioplasty is an valuable therapy for arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients.

Objective We aimed to translate the English version of Patient Dignity Inventory (PDI) into Chinese and test the reliability and validity of the Chinese version of PDI in terminal stage patients.Methods Totally 285 patients in terminal stage was recruited and investigated by the Chinese version of PDI.Results The internal consistency coefficient of the Chinese version of PDI ranged from 0.728 to 0.953,which was ＞0.70; split half coefficient was 0.561; the test-retest reliability was 0.824,which showed that internal consistency of Chinese version of PDI was good.The content validity index was 0.912.Factor analysis got five factors,which explained 62.172％ of the total variance; the factor loading of each item was ＞0.4.Conclusions The Chinese version of PDI has been proved to be reliable and valid.It can be used as a valid tool for the measurement of dignity in terminal stage patients.

As a new biotechnology, protein transduction connects the target fragment with biology active and protein transduction domain, and transducer it in to cells, exert its biological effects. Protein transduc-tion domain is a small molecule peptide, not only the protein transduction domain can penetrate through cell membrane, but could maintain the activity of its fusion protein. Protein transduction is an emerging biology technology, it has been applied into all aspects of cell gene regulation since its invention. In this article, we take Tat, Pdx-1 and Beta/NeuroD for instance and review the application of transduction protein in the dif-ferentiation of pancreatic stem cell.