Objective To investigate the influence of Enalapril Maleate Tablets on serum micro inflammatory indexes and nutritional indexes in maintenance hemodialysis patients. Methods A total of 90 patients with chronic renal failure treated by maintenance hemodialysis in our hospital from April 2015 to October 2016 were randomly divided into control group and experimental group, with 45casesin each group. The control group was treated with atorvastatin,andthe observation group was treated with atorvastatin combined with enalaprilmaleate tablets. After treatment,the levels of the inflammatory markers of high sensitive C reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), interleukin 6 (IL-6) and the nutritional index of plasma albumin(ALB), prealbumin(PA) in two groups were analyzed. Results After treatment, the levels ofHS-CRP, TNF-alpha in the observation group were lower than those in control group, the difference was statistically significant (P<0.05); The levels of IL-6, IL-8 in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05). The indexes of ALB and PA in the observation group after treatment were higher than those in the control group, the difference was statistically significant (P<0.05). Conclusion For the patients with maintenance hemodialysis treatment, the clinical effect of using conventional atorvastatin treatment combined with Enalapril Maleate Tablets is good, high safety, with further clinical promotion and application significance.

microRNAs play a critical role in breast tumorigenesis and progression, in which it might serve as oncogene, tumor suppressor gene, regulators of invasion, apoptosis and therapy resistance. Moreover,there has been a large body of evidences for the involvement of miRNAs in the self-renewal, differentiation and tumor formation of breast cancer stem cells. This review respectively summarizes the relations between microRNAs and breast cancer, breast cancer stem cell as well as the progresses of applying microRNAs to tumor therapy.

As a new biotechnology, protein transduction connects the target fragment with biology active and protein transduction domain, and transducer it in to cells, exert its biological effects. Protein transduc-tion domain is a small molecule peptide, not only the protein transduction domain can penetrate through cell membrane, but could maintain the activity of its fusion protein. Protein transduction is an emerging biology technology, it has been applied into all aspects of cell gene regulation since its invention. In this article, we take Tat, Pdx-1 and Beta/NeuroD for instance and review the application of transduction protein in the dif-ferentiation of pancreatic stem cell.

Objective To investigate the clinical effect of percutaneous balloon angioplasty for the treatment of arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients. Methods Percutaneous balloon angioplasty was performed in 14 hemodialysis patients with arteriovenous fistula stenosis or occlusion in upper extremity. The preoperative and post operative clinical manifestations, the color Doppler ultrasonographic findings, the blood flow during hemodialysis and the angiographic demonstrations were recorded and compared. Results After balloon dilatation, the constricted segment was remarkably dilated and the occluded site was re-opened in all patients. Angiographic findings showed that the degree of stenosis was less than 30%. Conclusion As a simple, mini-mvasive and safe technique with remarkable short-term effectiveness, percutaneous balloon angioplasty is an valuable therapy for arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients.

Pancreatic cancer is one of the most malignant diseases.With the development of biology,its pathogenesis has become more and more clear.There are a lot of signal pathway aberrant in pancreatic cancer cell including Notch signal pathway,k-ras signal pathway,hedghog signal pathway,NF-κB signal pathway and so on.Because of the widespread of NF-κB signal pathway aberration in pancreatic cancer cell,we think that NF-κB play a key role in the various kinds of aberrant signal pathways.So the NF-κB relative sighal pathways in pancreatic cancer are reviewed in this atticle.

Autophagy is a physiological process which delivers the mutant cytoplasmic proteins and dysfunctional subcellular organs into lysosomes for degradation to generate fuel in the deficiency conditions. It is mainly classified into macroautophagy, microautophagy and chaperon-mediated autophagy (CMA), as well as the selective autophagy such as mitophagy and aggrephagy. This review mainly introduces the key molecular markers of macroautophagy, CMA and mitophagy.
Autophagy ; Humans ; Lysosomes ; Mitochondrial Degradation ; Molecular Chaperones

Autophagy is a physiological process which delivers the mutant cytoplasmic proteins and dysfunctional subcellular organs into lysosomes for degradation to generate fuel in the deficiency conditions. It is mainly classified into macroautophagy, microautophagy and chaperon-mediated autophagy (CMA), as well as the selective autophagy such as mitophagy and aggrephagy. This review mainly introduces the key molecular markers of macroautophagy, CMA and mitophagy.

Objective We aimed to translate the English version of Patient Dignity Inventory (PDI) into Chinese and test the reliability and validity of the Chinese version of PDI in terminal stage patients.Methods Totally 285 patients in terminal stage was recruited and investigated by the Chinese version of PDI.Results The internal consistency coefficient of the Chinese version of PDI ranged from 0.728 to 0.953,which was ＞0.70; split half coefficient was 0.561; the test-retest reliability was 0.824,which showed that internal consistency of Chinese version of PDI was good.The content validity index was 0.912.Factor analysis got five factors,which explained 62.172％ of the total variance; the factor loading of each item was ＞0.4.Conclusions The Chinese version of PDI has been proved to be reliable and valid.It can be used as a valid tool for the measurement of dignity in terminal stage patients.

Comprehensive budget management has important significances in controlling public hospital operating costs, refining strategic objectives and optimizing work performance appraisals. In the process of comprehensive budget management, implementation effects of some public hospitals are not ideal. The major reasons are unsound corporate governance structure, inadequate implementation and imperfect evaluation index. Through the analyzing these important influencing factors and proposing the corresponding measures, the comprehensive budget management was smoothly carried out in public hospitals, which finally improved the management level of hospital.

Objective To explore the effects of patient mutual help-oriented nursing model on social support and hope level in lung cancer patients.Methods Totally 72 lung cancer patients were recruited into the study and divided into the experimental group and the control group with 36 patients in each group.The control group was given routine care,while the experimental group received additional patient mutual help-oriented nursing interventions:physically and psychologically well recovered patients were asked to give emotional communication and interaction to patients newly diagnosed with lung cancer,The Social Support Scale and Herth Hope Index were used for evaluation after the intervention.Results The patients' social support and hope level of the intervention group were significantly better than those of the control group after intervention.Conclusions Patient mutual help-oriented nursing model can improve social support and hope level of lung cancer.