Cheyne-Stokes Respiration ; physiopathology ; therapy ; Heart Failure ; complications ; physiopathology ; Humans ; Positive-Pressure Respiration ; methods ; Sleep Apnea, Central ; therapy ; Stroke Volume ; Ventricular Function, Left

Adiponectin ; blood ; C-Reactive Protein ; analysis ; Cardiovascular Diseases ; etiology ; Continuous Positive Airway Pressure ; Humans ; Inflammation ; complications ; Sleep Apnea, Obstructive ; blood ; complications ; therapy

Humans ; Otolaryngology ; Periodicals as Topic ; trends

OBJECTIVE:To probe into the incidence,latency,clinical features and prevention of the antibiotic-associated diarrhea (AAD). METHODS:968 patients with chronic obstructive pulmonary diseases (COPD) treated with antibiotics in the respiratory department of our hospital were prospectively followed for 30 days immediately after administration of antibiotics. RESULTS:The incidence of AAD was 8.47% (82/968) and the latency of AAD was (8.35?5.19) days. 84.15%(69/82)of the AAD cases manifested as simple diarrhea. The AAD was chiefly induced by cephalosporins (42.68%) and penicillins (23.17%). The incidence of AAD increased markedly if the length of the antibiotic treatment was ≥7 days or if at least 3 kinds of the antibiotics were used concomitantly. After discontinuation or alteration of the antibiotics or administration of microbial ecological agents,metronidazole or vancomycin,71(86.59%) of the total 82 AAD cases were cured,10(12.20%) improved and 1 (1.21%) showed no response. CONCLUSION:AAD is a frequent complication of antibiotic therapy. A powerful measure to prevent AAD is rational use of antibiotics.

After more than 30 years of development, noninvasive positive pressure ventilation (NPPV) has become one of the main treatments of sleep-disordered breathing (SDB) in the world. It is the wide application of this technology that makes breakthrough in SDB treatment, and has given rise to a new interdisciplinary area sleep medicine. In China, sleep medicine started in late of 1980's, in recent years, with the development of economy and the improvement of recognization, the application of NPPV in Chinese market has become one of the fastest growing in the world. NPPV technology also extends gradually to the treatments of patients with respiratory failure due to different causes, such as severe acute respiratory syndrome and COPD.
China ; Humans ; Positive-Pressure Respiration ; Respiratory Insufficiency ; Sleep Apnea Syndromes ; therapy ; Sleep Medicine Specialty ; trends

Objective To assess the correctness of statistical methods applied in the research papers of Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) and to provide suggestions for further improving.Methods Papers were obtained from CJNMMI by multi-stage sampling method between 2007 and 2011 according to the number of journals and articles each year.The statistical methods were reviewed in the aspects of statistical design,description,inference and expression.Results A total of 116 papers were collected.For the statistical design,99.1％ (115/116) used the control group and all were applied properly.The methods of randomization and blinding were used in 16.4％ (19/116) and 8.6％ (10/116) of papers,respectively,with 6 and 3 papers applied incorrectly.Statistical description was used in all papers with an accurate rate over 90.0％.The index for statistical description mainly included relative number,mean and standard deviation.The frequency for the usage of statistical tables was 45.7％ (53/116) and all were applied correctly.In 71.6％ (83/116) of papers,statistical inference methods were used,including t test,x2 test and analysis of variance.The overall incorrect rate was 29.7％ (27/91),with 27.8％ (5/18),25.5％ (12/47) and 24.0％ (6/25) for analysis of variance,t test and x2 test,respectively.The frequency for the usage of advanced statistical inference methods was 20.5％ (17/83) and all were applied correctly.For the statistical expression,98.0％ of papers provided the sample size and statistics.The incorrect rate of statistical expression was 60.3％ (70/116) and majority of the mistakes was the lack of basis for determining the sample size.Conclusions The overall correctness of statistical methods applied in the papers of CJNMMI was good,especially in statistical design,statistical description and advanced statistical inference methods.However,quality application skills need to be improved in areas such as methods of randomization,blinding,basic statistical inference and statistical expression.

Since the first reported case of swine influenza A in Mexico, a total of 15 510 cases have been confirmed in 53 countries by May 29, 2009. On April 29, 2009, the World Health Organization (WHO) raised its pandemic alert from grade 4 to grade 5. The virus is described as a new subtype of A/H1N1 and is not detected in pigs or humans previously. The virus is sensitive to oseltamivir and zanamivir, but resistant to amantadine and rimantadine. The genetics of the virus are so novel that humans are unlikely to have much immunity to it. The virus can transmit from human to human; therefore it is necessary to enforce quarantine measure for close contactors because the virus transmits during latency. Precaution methods like covering noses and mouths with a tissue when coughing or sneezing can reduce the transmission opportunity. Hands should be washed frequently with soap, especially after coughing or sneezing. Public places with ventilation conditions, personal health behavior and health condition are critical for the prevention and control of this epidemic.

Objective: To analyze evolutionary characteristics of the matrix protein (M) and nucleoprotein (NP) genes of influenza virus A/H1N1 in 2009 pandemic. Methods: The M and NP genes of A/H1N1 viruses were downloaded from NCBI database. MEGA4.0 software and NJ method were used for sequence alignment, protein sequence alignment, and the phylogenetic tree construction. Meanwhile, Epi Info software was used to analyze the linear trend of evolutionary distance of the M and NP genes of human H1N1 strains isolated during 1918 to 2009. Results: The M and NP gene sequences were similar among the novel A/H1N1 viruses, but different from those of the previous influenza H1N1 viruses. Using reference sequences of human H1N1 strains isolated during 1918 to 2008, we found that changes in evolutionary distances of the M genes between novel A/H1N1 strains and each of the reference A/H1N1 strains increased with increasing year intervals (Ptrend = 0.001). Compared with the amino acid sequence of M2 protein of reference human A/H1N1 virus strains isolated during 1918 to 2008, the novel A/H1N1 viruses had the amino acid substitutions at 6 sites: 11, 43, 54, 57, 77, and 78. Compared with swine and avian A/H1N1, the novel A/H1N1 virus only had the amino acid substitutions at 43 and 77. Conclusion: The NP gene of novel A/H1N1 virus, which is routinely considered as a conserved sequence, is different from those of the previously isolated human H1N1 influenza viruses; the related mechanisms and consequences on viral activity remain to be elucidated. The substitution to threonine at 11 and 43 amino acids of M2 protein might contribute to amantadine resistance of the novel H1N1 virus pandemic in 2009.

Objective To explore the influence of thyroid status on serum level of leptin and expression of leptin mRNA in rats with hypothyroidism or hyperthyroidism.Methods Fifty rats were artificially rendered hyperthyroidism and hypothyroidism by L-thyroxine or methimazole and divided into 5 groups.The serum of T 3,T 4,TSH,leptin concentration and expression of leptin mRNA were measured in 5 groups.Results Serum leptin concentration was significantly correlated with weight of rats in 5 groups(P