Signaling pathways of growth factors and their receptors not only diversify the biological behaviors in normal cells,but also play important roles in regulation of tumor cell proliferation,differentiation,transformation and migration.Aberrant expression of insulin-like growth factor-1 receptor (IGF-1R) has been observed in multiple hematological malignancies including multiple myeloma,lymphoma and leukemia.The existence of IGF-1R signaling pathway is a potential therapeutic target of hematological malignancies.This review summarizes recent findings of the aberrant expression of IGF-1R and therapeutic intervention in hematological malignancies.

Carrying out reasonable classification of literature collection and analyzing the characteristics scientifically, the paper points out adjusting development policies for collection, constructing characteristic collection system and optimizing the quality of acquisition librarian, which would play an positive role in improving the construetion of literature resource system in libraries.

Objective To study the clinical effect of combination of kurarinone and thymosin ?_1 for injection in treating chronic hepatitis B.Method One hundred and fifty-six patients with chronic hepatitis B were randomized into two groups,additional KR combined thymosin ?_1 for injection was given to treated group,and KR to control group.The therapeutic course for them was 6 months.We compared the serum ALT、 hepatitis B virological markers、T lymphocyte response before and 6 months after treatment.Results After treatment,the results showed that the levels of CD_3+、CD_4+、CD_4+/CD_8+ T cell in CHB patients of treatment were much higher than control groupnt.The ratio HBeAg and HBV-DNA loss were increased,the difference was significant(P

Objective To study the effect of Chinese medicine fumigation bath combined with acupuncture and hemorrhoids on improving the pain edema of elderly patients after anorectal pain.MethodsA total of 168 elderly patients with anorectal surgery were enrolled in our hospital from April 2013 to April 2016.The patients were randomly divided into two groups: the group (n=84) and the conventional treatment group (n=84) N=84).Routine treatment group given conventional Western medicine and potassium permanganate solution bath treatment, fumigation acupuncture group on the basis of conventional Western medicine treatment to give Chinese fumigation bath and acupuncture hemorrhoids treatment, compared the two groups of clinical efficacy, pain, Wound recovery and skin adverse reactions.ResultsThe total effective rate, no pain rate, edema disappearance time and wound healing time were 94.0%, 38.1%, (5.13±1.59) d, (16.47±4.06) d, respectively, compared with those in the conventional treatment group 84.5%, 22.6%, (6.74±1.23) d, (19.38±3.75) d, the difference was statistically significant (P<0.05).ConclusionChinese medicine fumigation bath combined acupuncture hemorrhoids acupuncture points can improve the local blood circulation, anti-bacterial anti-inflammatory pain, relieve senile patients after anorectal pain edema symptoms, speed up the rehabilitation process.

Objective To explore the relationship between dental trauma for children and their psychological behavior characteristics.Methods By using the method of case-control study,7-11 years of age children accepting oral health examination in our department were asked to fill in the questionnaire.The children without dental trauma were selected as the control group and the children with permanent tooth injury were selected as the injury group.Each group has 57 cases.All children finished the Eysenck personality questionnaire (EPQ) and their parents finished the Achenbach child behavior capacity list (CBCL).Results (1) The average CBCL score (32.51±20.41) and scores of P and N branch capacity lists in EPQ (44.72± 11.67,48.05± 12.39) of the injury group were all higher than those of the control group (17.19± 11.67,37.64± 8.17,41.40± 8.78) (P＜0.01).(2) The detecting rate of behavior problems in injury group was also higher than that of the control group (33.33％,7.02％,P＜0.01),OR=6.63,95％ CI =2.09-21.05.Boys of the injury group had higher scores than those in the control group in seven factors (depression,social withdrawn,restlessness,violation of discipline,attack,compel and social problems) (P＜0.05),and girls of the injury group also had higher scores than those in the control group did in three factors (depression,social withdrawn and attack) (P＜0.05).(3) In the injury group,boys had higher scores in the factor of schizoid anxiety than girls did (P＜0.01),risk factors were depression (OR=0.529,95％ CI =0.292-0.959),social withdrawn (OR=2.274,95％ CI =1.311-3.944),restlessness (OR=0.426,95％ CI =0.213-0.852),violation of discipline (OR=0.426,95％ CI =0.213-0.852) and attack (OR=0.644,95％ CI =0.459-0.903).However,girls had higher scores in the factor of depression than boys (P＜0.05),their risk factor was depression (OR=0.573,95％ CI =0.357-0.919).Conclusion There is a certain correlation between tooth injury and their psychological behavior characteristics of children.

Breast ; pathology ; Carcinoma, Intraductal, Noninfiltrating ; diagnosis ; metabolism ; pathology ; Female ; Humans ; Hyperplasia ; metabolism ; pathology ; Keratin-5 ; metabolism ; Keratin-6 ; metabolism ; Precancerous Conditions ; diagnosis ; metabolism ; pathology ; Stem Cells ; metabolism ; pathology

Objective To research the pathogenies' types and analyze the antibacterial drug' s using rationality from the children with acute respiratory infection,our study were generated by pediatric department from the hospital lasting 2 years.Methods A total of 93 pediatric patients with acute respiratory infection admitted from December 1,2010 through November 30,2012 were enrolled into study.The throat swabs from 93 patients were sent to the Beijing Center for Disease and Prevention (CDC) to identify the influenza virus,syncytial virus and mycoplasma with rapid nucleic acid test.The specimens of sputum from hospitalized patients were sent to the hospital bacterial laboratory for bacteria culture.With the Children Drug Utilization Index (cDUI),the rationality of using antibiotics was estimated.The database was established by using SPSS version 18.0 software and the data were analyzed to determine the statistical distinction among the percentage by the Chi square test (P ＜ 0.05).Results Of them,70.96％ pediatric patients were below 3 years old (excluding newborns).Of them,62.36％ patients had positive findings of viral infection.The predominant viruses of respiratory infection were syncytial virus accounting for 30.43％,the influenza viruses 24.63％ and the para-influenza virus 10.14％.The patients with positive results in vital test were more vulnerable to lower respiratory infection than those with negative results.The pneumonia patients with positive finding of syncytial virus accounted for 85.71％ (18 patients) in which the median cDUI was 1.30.The antibiotics were given to 28 pneumonia patients with positive virus test,in which the median cDUI was 1.05.Of 28 pneumonia patients,4 (16％) had positive bacteria growth in sputum cultures,and 4 cases (16％) had positive bacteria growth in blood cultures.Conclusions In the district of hospital,the lower respiratory infection was usually caused by viruses.Therefore,antibiotics should not be given in patients without evidence of bacterial infection.It is a irrational strategy to use antibiotics in those patients when the Children Drug Utilization Index is high (＞ 1.0).It is paramount important to notice that the percentage of positive bacteria growth in sputum cultures is usually not high because the antibiotics are given by OPD physicians before hospitalization of patients with bacterial infections in the acute respiratory illness.

The occurrence of total chronic coronary occlusion is about 10% in patients undertaking coronary angiography.These patients are often asymptomatic,but can have angina pectoris after exercise and in other conditions increasing oxygen assumption,a few have cardiac insufficiency.The most effective therapies are coronary arterial bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) plus stenting.The clinical manifestation can be alleviated and cardiac function improved after successful intervention.

Toll-like receptor (TLR) plays a crucial role in innate immune response and the subsequent induction of adaptive immunity. TLR is expressed on immune cells as well as epithelial cells and tumor cells. When endogenous and exogenous ligands bind with TLR, TLR signaling pathways are activated and a large number of inflammatory cytokines are released, creating an inflammatory microenvironment and leading to tumor formation, invasion and metastasis.

In this paper, published by COSOInternal Control-integrated framework Theory and the actual situation in China's state-owned hospitals, the hospital selected the elements of the control environment for the study, respectively, from the organizational structure, the values of the main staff, the hospital management and operation of the concept of style, the hospital audit department, as well as hospitals and other human resource policies in terms of five of the impact of the internal control system analysis, and made light of the actual current state-owned hospitals in the above-mentioned aspects of the prevailing problems and gives some solutions.