Carrying out reasonable classification of literature collection and analyzing the characteristics scientifically, the paper points out adjusting development policies for collection, constructing characteristic collection system and optimizing the quality of acquisition librarian, which would play an positive role in improving the construetion of literature resource system in libraries.

Signaling pathways of growth factors and their receptors not only diversify the biological behaviors in normal cells,but also play important roles in regulation of tumor cell proliferation,differentiation,transformation and migration.Aberrant expression of insulin-like growth factor-1 receptor (IGF-1R) has been observed in multiple hematological malignancies including multiple myeloma,lymphoma and leukemia.The existence of IGF-1R signaling pathway is a potential therapeutic target of hematological malignancies.This review summarizes recent findings of the aberrant expression of IGF-1R and therapeutic intervention in hematological malignancies.

Objective To study the clinical effect of combination of kurarinone and thymosin ?_1 for injection in treating chronic hepatitis B.Method One hundred and fifty-six patients with chronic hepatitis B were randomized into two groups,additional KR combined thymosin ?_1 for injection was given to treated group,and KR to control group.The therapeutic course for them was 6 months.We compared the serum ALT、 hepatitis B virological markers、T lymphocyte response before and 6 months after treatment.Results After treatment,the results showed that the levels of CD_3+、CD_4+、CD_4+/CD_8+ T cell in CHB patients of treatment were much higher than control groupnt.The ratio HBeAg and HBV-DNA loss were increased,the difference was significant(P

Objective To study the effect of Chinese medicine fumigation bath combined with acupuncture and hemorrhoids on improving the pain edema of elderly patients after anorectal pain.MethodsA total of 168 elderly patients with anorectal surgery were enrolled in our hospital from April 2013 to April 2016.The patients were randomly divided into two groups: the group (n=84) and the conventional treatment group (n=84) N=84).Routine treatment group given conventional Western medicine and potassium permanganate solution bath treatment, fumigation acupuncture group on the basis of conventional Western medicine treatment to give Chinese fumigation bath and acupuncture hemorrhoids treatment, compared the two groups of clinical efficacy, pain, Wound recovery and skin adverse reactions.ResultsThe total effective rate, no pain rate, edema disappearance time and wound healing time were 94.0%, 38.1%, (5.13±1.59) d, (16.47±4.06) d, respectively, compared with those in the conventional treatment group 84.5%, 22.6%, (6.74±1.23) d, (19.38±3.75) d, the difference was statistically significant (P<0.05).ConclusionChinese medicine fumigation bath combined acupuncture hemorrhoids acupuncture points can improve the local blood circulation, anti-bacterial anti-inflammatory pain, relieve senile patients after anorectal pain edema symptoms, speed up the rehabilitation process.

Objective To explore the relationship between dental trauma for children and their psychological behavior characteristics.Methods By using the method of case-control study,7-11 years of age children accepting oral health examination in our department were asked to fill in the questionnaire.The children without dental trauma were selected as the control group and the children with permanent tooth injury were selected as the injury group.Each group has 57 cases.All children finished the Eysenck personality questionnaire (EPQ) and their parents finished the Achenbach child behavior capacity list (CBCL).Results (1) The average CBCL score (32.51±20.41) and scores of P and N branch capacity lists in EPQ (44.72± 11.67,48.05± 12.39) of the injury group were all higher than those of the control group (17.19± 11.67,37.64± 8.17,41.40± 8.78) (P＜0.01).(2) The detecting rate of behavior problems in injury group was also higher than that of the control group (33.33％,7.02％,P＜0.01),OR=6.63,95％ CI =2.09-21.05.Boys of the injury group had higher scores than those in the control group in seven factors (depression,social withdrawn,restlessness,violation of discipline,attack,compel and social problems) (P＜0.05),and girls of the injury group also had higher scores than those in the control group did in three factors (depression,social withdrawn and attack) (P＜0.05).(3) In the injury group,boys had higher scores in the factor of schizoid anxiety than girls did (P＜0.01),risk factors were depression (OR=0.529,95％ CI =0.292-0.959),social withdrawn (OR=2.274,95％ CI =1.311-3.944),restlessness (OR=0.426,95％ CI =0.213-0.852),violation of discipline (OR=0.426,95％ CI =0.213-0.852) and attack (OR=0.644,95％ CI =0.459-0.903).However,girls had higher scores in the factor of depression than boys (P＜0.05),their risk factor was depression (OR=0.573,95％ CI =0.357-0.919).Conclusion There is a certain correlation between tooth injury and their psychological behavior characteristics of children.

Breast ; pathology ; Carcinoma, Intraductal, Noninfiltrating ; diagnosis ; metabolism ; pathology ; Female ; Humans ; Hyperplasia ; metabolism ; pathology ; Keratin-5 ; metabolism ; Keratin-6 ; metabolism ; Precancerous Conditions ; diagnosis ; metabolism ; pathology ; Stem Cells ; metabolism ; pathology

Immune thrombocytopenia (ITP) is the most common hemorrhagic disease in childhood,and immunological abnormality is the most common cause of this disease.Humoral immune abnormalities are the major cause of ITP,involving platelet,platelet membrane surface glycoproteins associated antibodies,impaired Breg cells and upregulation of platelet Toll like receptors.Cellular immune abnormalities include the imbalance of Th1/Th2 cells results in increased inhibitory cytokines [interleukin (IL)-2,interferon-α,tumor necrosis factor-β],IL-17 and Th17 cells in patients with chronic ITP are higher than those in control group,and Treg decline is also common seen in ITP.Increased expression of apoptosis related genes Bak and Bax are also the cause of chronic ITP.Helicobacter pylori is an important cause of chronic ITP,which can be eased in some cases but not effective in new diagnosed cases.Vaccination can lead to ITP,repeated vaccines are applied usually in 3-6 months after the onset.

The pharmacodynamic methodology of Chinese materia medica (PMCMM) at present was discussed comprehensively in this article and the problems were found While the primary study on the PMCMM was carried out This article offers that the development of the science of Chinese traditional medicine is the premise and basis of the study of PMCMM, especially that the breakthrough of modern study on the theory of viscera state and channel theory and channel tropism theory leads dominantly the study of PMCMM; the four dimensional system theory has been investigated in PMCMM, on the two dimensional basis of the physical foundation of medicinal efficacy and the mechanism of medicinal efficacy, the time dimension and human spirit dimension are added

The analysis of 2013 circulating foreign and Chinese books in Library of Capital Medical University showed that the number of foreign and Chinese books classified into R Medicine and Healthand I Literaturewas the largest ,which thus provided the evidence for book acquisition ,book circulation and library holding develop-ment.Certain suggestions were put forward for improving the utilization of books, such as enforcing the acquisition and catalogue , and recommending books that should be bought .

Objective To explore the effect of Utstein registry on improving the missing key information during cardiopulmonary resuscitation.Methods A total of 111 emergency medical records of cardiopulmonary resuscitation from January 1 to December 31 2012 were as control group,and 100 Utstein registry of cardiopulmonary resuscitation from June 1 2013 to May 31 2014 were as experimental group.The missing key information during cardiopulmonary resuscitation were compared between two groups.Results The missing key information during cardiopulmonary resuscitation in monitoring the rhythm of the heart for the first time,cardiopulmonary resuscitation start time,defibrillation time for the first time,established assisted ventilation time,recovery delivery time for the first time,recovery termination time were 84.68％(94/111),16.22％ (18/111),89.58％ (43/48),76.58％ (85/111),72.07％ (80/111),30.63％ (34/111) in control group,and 9.00％(9/100),0,0,4.00％(4/100),7.00％97/1000,2.00％(2/100) in experimental group,and there were significant differences (P＜ 0.01).Conclusions Utstein registry can promote perfect cardiopulmonary resuscitation information registration,so as to provide the basis for cardiopulmonary resuscitation quality continuous improvement.