ObjectiveTo study the optimized security strategy for informing cancer patients with the disease,and let patients be fully informed and even more actively cooperate with doctors while they are under treatment.MethodsGrouped with adversity quotient (AQ) score,these cancer patients were in comparison with those who had been informed by other ways without support strategy,and different groups of patients were estimated in different strategies in accordance with self-rating anxiety scale (SAS) and self-rating depression scale (SDS).Results With certain strategies,high and low AQ score groups' SAS and SDS scores stably restored in 1 day to 1 week,and the differences had statistical significance(P ＜ 0.01 ).The patients were well-informed without any difficulty and actively cooperated with treatment.No related factors led to self-mutilation,suicide and other serious incidents.While the SAS and SDS scores of the control group who were not informed by the strategy were not satisfactorily recovered,and the patients could not actively cooperate with the doctors.Especially being notified after 1 d to 1 week,the SAS and SDS scores had no significant improvement,and the differences had no statistical significance compared with themselves ( P ＞ 0.05 ).It is difficult to avoid the occurrence of serious incidents.Conclusion Based on AQ score,it is safe and effective to inform cancer patients of their disease condition by individual strategies.It not only respects patients rights,but also gains the active cooperation of the patients,and is helpful for treatment with minimizing adverse effects.

BACKGROUND:Occurrence and development of diabetic complications is closely related to the severity of oxidative stress imbalance in the body. OBJECTIVE:To investigate the effect of embryonic stem cel s on oxidative stress response of rats with diabetic nephropathy. METHODS:Primarily cultured rat embryonic stem cel s were observed for cel morphology and surface antigen detection. Sprague-Dawley rats were divided into experimental group (two injections of embryonic stem cel s via the tail vein), model group (injection of the same volume of PBS), and normal control group (with no modeling, intraperitoneal injection of sodium citrate-citrate buffer). In the former two groups, the rats were intraperitoneal y injected sodium citrate-citrate buffer diluted streptozotocin to establish diabetic nephropathy models before treatment. At 5 weeks after the last injection, blood glucose level, renal function indicators (urine protein/urine creatinine, blood urea nitrogen and serum creatinine) were tested in each group;contents of malondialdehyde and protein carbonyl were detected in the kidney;the expression level of superoxide dismutase was detected by western blot assay. RESULTS AND CONCLUSION:The embryonic stem cel s were oval or round, with clear boundary and good refraction, and highly expressed Oct-4 and SSEA-1. Compared with the control group, renal biochemical indicators, malondialdehyde and protein carbonyl contents were significantly increased, while the expression level of superoxide dismutase was decreased dramatical y in the model group and experimental group (P<0.05);compared with the model group, the renal biochemical indicators, malondialdehyde and protein carbonyl contents were dropped significantly in the experimental group, but the expression of superoxide dismutase was significantly rebounded (P<0.05). Taken together, embryonic stem cel s can reverse the occurrence and development of diabetic nephropathy by inhibiting oxidative stress in progress.

Objective To study the significance of serum human epididymis protein 4 ( HE4 ) and human cartilage glycoprotein-39(YKL-40) in the diagnosis of ovarian cancer .Methods 100 patients with ovarian cancer , 90 patients with benign tumor of ovary and 50 healthy people were enrolled .Serum HE4 and YKL-40 were detected . Results The positive rates of serum HE 4 in ovarian cancer group , ovarian benign tumor group and healthy group were 86.0%,5.5%,2.0%.The positive rate of serum HE4 in ovarian carcinoma was significantly higher than that in benign ovarian tumor group and the healthy group (χ2 =31.06,30.82,all P<0.01).The positive rates of serum YKL-40 in ovarian cancer group ,ovarian benign tumor group and healthy group were 82.0%,3.3%,2.0%.The positive rate of serum YKL-40 in ovarian carcinoma was significantly higher than that in benign ovarian tumor group and the healthy group(χ2 =30.92,32.06,all P<0.01).Serum HE4 in the diagnosis of ovarian cancer ,the sensitivity was 86.0%,specificity of 95.7%,accuracy of 91.7%.Serum YKL-40 in the diagnosis of ovarian cancer ,the sensitivity was 82.0%,specificity of 97.1%,accuracy of 90.8%.For the joint detection,the sensitivity for diagnosis of ovarian cancer was 92.0%,and the specificity was 93.6%,accuracy was 95.0%,higher than those of the single detection . Conclusion Combined with serum HE 4 and YKL-40 detection can significantly improve the diagnostic accuracy of ovarian cancer patients .

Cardiovascular Diseases ; etiology ; Chronic Disease ; Humans ; Hypertrophy, Left Ventricular ; etiology ; Kidney Diseases ; complications ; Risk Factors

Leukemia inhibitory factor(LIF) is a multifunctional cytokine.In recent years,investigations have made some advancement in the effect of LIF on central nervous system.LIF shows a high expression in various central nervous system diseases and related animal models,which shows a neuroprotective effect most time in central nervous system injuries.LIF is defined as a neurotrophic factor.It might provide a new strategy for the therapy of central nervous system diseases to undertake further studies on leukemia inhibitory factor and central nervous system diseases.

Objective:To investigate the cesarean perioperative usage in patients, and the rationality of drug evaluation.Methods: A retrospective analysis in February 2012 to August 2013 in our hospital for treatment of cesarean perioperative clinical information on the use of antimicrobial agents for statistics, and use frequency analysis method for analysis.Results: All patients with the highest rates of antibiotic Ornidazole, the highest consumption of Ornidazole, the highest amount of sales Ornidazole, cefotiam, the highest frequency of drug use Ornidazole use reasonable potassium penicillin drugs, cefotiam, ornidazole; most unreasonable use drugs penicillin, cefazolin amount of sorting/DDDs (medication on the number) were higher than a sort; cefmetazole the amount of sorting/ DDDs (medication on the number) Sort lowest value, and less than 1.Ratio of only 0.56% monotherapy, combination therapy of two drugs highest proportion is 76.67%. Conclusion: Perioperative cesarean section used antibiotics exists that use a longer time, the problem of improper dosage should strengthen supervision and improve the rational use of medicines in hospitals level.

Objective To determine the value of multimodal analgesia used to reduce the degree of postoperative cognitive dysfunction (POCD) in the aged patients undergoing total hip-replacement surgery.Methods Fifty ASA Ⅱ-Ⅲ patients aged 60-79 years old,undergoing total hip-replacement surgery were divided randomly into trial group and control group,each group 25 patients.The visual analogue scale (VAS) and the usage amount of sufentanil were recorded after operation.The mini-mental state examination (MMSE) was used to assess the cognitive function before operation and after operation.Results The VAS scores after operation for 3 d in two groups was significantly lower than that after operation for 1 d (P ＜ 0.05),the VAS scores after operation for 1,2 d in trial group was significantly lower than that in control group (P ＜ 0.05).The usage amount of sufentanil at every time in trial group was also lower than that in control group (P ＜0.05).The MMSE scores before operation and after operation for 3 d in two groups had no significant difference (P ＞ 0.05).The MMSE scores after operation for 1,2 d in trial group was significantly higher than that in control group (P ＜ 0.05).The MMSE scores after operation for 1,2 d in two groups was significantly lower than that before operation (P ＜ 0.05).Severe POCD of both groups was not occurred.Conclusion Multimodal analgesia may reduce early postoperative cognitive dysfunction of the aged patients undergoing total hip-arthroplasty via general anesthesia.

Analysis of the hurdles to cross for public hospitals in China in their reforms, and appraisal of the achievements and setbacks found in the healthcare system reform in the past 30 years. These form the basis for the recommendations for pragmatic reform measures in public hospitals, for improvement of the medical charge pricing system and clarification of the coverage of the essential medical services; for establishment of medical groups or medical consortiums and regulation of patients treatment seeking behavior; and for finalizing the corporate governance structure of public hospitals.

Objective To investigate the types and features of skin soft tissue injury caused by earthquake disaster and to explore the necessity of early intervention of plastic surgery.Methods 149 wounded patients of"5.12"Sichuan earthquake were retrospectively analyzed and summarized.Results Incidence of skin soft tissue injury was 53%.53 of the wounded were diagnosed as"multiple skin soft tissue injury"and 14 were"skin soft tissue necrosis".Feature of skin soft tissue injury was summarized.Through analysis of typical case,a type of serious skin soft tissue necrosis was reported first time,which occurred in the long-time buried survivors after earthquake.Conclusion The early intervention of plastic surgery will help diagnose and treat the wounded,and shorten the recovery time.