Objective To investigate the clinical value of combined detection of serum human epididymis protein 4(HE4),carbo-hydrate antigen 125(CA125)and tumor marker(CEA)in the diagnosis and staging of ovarian cancer.Methods 90 cases of ovarian cancer(ovarian cancer group),120 cases of benign ovarian disease(ovarian benign group)and 60 cases of healthy women(healthy control group)were selected from March 2014 to 2016 March in our hospital.The levels of HE4 and CA125 and CEA were detected by immunochemiluminescence assays,the results of the three groups were compared and analyzed.Results The positive rate of 3 indicators in the ovarian cancer group was significantly higher than that of the ovarian benign group and the healthy control group (P <0.05).The positive rates of combined detection of Ⅰ-Ⅳ in ovarian cancer were 81.2%,92.1%,97.4% and 100.0%,and CEA,CA125 and HE4 joint inspection in different stages of ovarian cancer positive rate is significantly higher than that of single in-dex positive detection rate.Conclusion The clinical value of HE4,CA125,CEA combined test for the diagnosis and staging of ovar-ian cancer is significant,it is worth to be further promoted.

Objective To discuss the occurrence of adverse drug reactions (ADR) induced byDanhong Injection; To provide references for rational clinical medication.Methods Literature related to ADR induced byDanhong Injection was retrieved from CNKI, Wanfang database and CBM database during Jan. 2004 to Dec. 2015. Literature was selected based on inclusion and exclusion criteria. Data were collected and analyzed by metrology.Results 116 cases of ADR induced byDanhong Injection were included. The analysis showed that there was no significant correlation between ADR and gender. Most of ADR cases occurred over the age of 50 and within 30 min after medication. Multiple organs and systems were involved in ADR. Damages in skin tissue, the whole body, and respiratory system were common. Relevant clinical symptoms were mainly itching, skin rash, fever, shiver and shortness of breath. However, anaphylactic shock was needed to be aware of.Conclusion The incidence of ADR induced byDanhong Injection requires great attention in order to standardize medication and improve safety.

Objective To compare methimazole and propylthiouracil affecting liver function by treating hyperthyroidism.Methods Total 80 patients with hyperthyroidism were randomly divided into two groups.Group A (41 cases) was given methimazole,group B (39 cases) was given propylthiouracil.The effect of methimazole and propylthiouracil affecting liver function by treating hyperthyroidism was evaluated by the indexes of thyroid function,liver function,liver damage,and adverse reaction during treatment.Results Before treatment,there were no statistical significance on FT3 and FT4 between two groups.After treatment,the FT3and FT4 were decreased and TSH was increased in two groups (P ＜ 0.05).But there were no statistical significance between two groups.Before treatment,there was no statistical significance on ALT,AST,and GGT between two groups.After treatment,the ALT,AST,and GGT increased in group B and higher than that of group A (P ＜ 0.05).The ALT,AST,and GGT had no change before and after treatment in the group A.During treatment,there were five cases of liver injury in group A and 14 cases in group B.The liver injury rate of group B was higher than that of group A (P ＜ 0.05) and injury time of group B was later than that of group A.During treatment,there was no statistical significance on adverse reaction rate between two groups.Conclusion The efficacy of methimazole was equal to propylthiouracil in treating hyperthyroidism.Compared with propylthiouracil,the methimazole had less injury on liver but induce the liver injury in earlier.It is suggested that the patients should check the liver function regularly during treatment.

Hepatitis B recurrence is one of the most frequent complications that will probably result the treat failure of liver transplantation. As many as 80% of patients with HBV are reinfected by this virus after liver transplantation. This has been the most deadly case that threatens patient survival amongst all problems emerging from liver transplantation executed for Hepatitis B ralated hepatocirrhosis. In recent years a great deal of prophylaxis practices have been adopted, which has greatly reduced the possibility of Hepatitis B recurrence. The present paper reviews the causes and treatment of Hepatitis B recurrence after liver transplantation.

Objective To investigate the related factors of encephalopathy following orthotopic liver transplantation (OLT).Methods The clinical data of 128 patients who underwent liver transplantation consecutively between October 2001 and October 2003 were analyzed retrospectively by SPSS 10.0 . All clinical factors were analyzed by Crosstabs or independent-samples t test. A mutivariative analysis of these significant factors was done by using the Binary Logistic Regression.Results Encephalopathy occurred in 21 cases within the first week after operation, including 19 cases of Child-pugh C and 2 cases of Child-pugh B. There was a higher occurrence in the patients with chronic severe hepatitis or undergoing re-transplantation ( P 0.05 ). In the encephalopathy group the incidence of renal failure after transplantation and infection pre- or postoperation was higher than in control group ( P

Exact staging is the important basic tool for choosing reasonable therapy,and accurate staging is also critical for prognosis evaluation,comparison of different therapies and information communication.As the imaging methods for staging of esophageal carcinoma before therapy,CT,MRI,EUS,PET and PET/CT are different in sensitivity,specificity and accuracy for different regions and different organs,depending on the different imaging mechanism.Combination of different methods is the practical way to improve the accuracy of staging.Combining EUS with CT seems to be a practical and precise way.

This is a report on the contribution and characteristic of MG, antigen recognized by gastric cancer monoclonal antibody with immunohistochemical staining in gastric cancer, and its vicinal and distant tissues. There is a positive rate of 84% (42/50) in gastric cancer, and 32% (16/50) in the epithelia adjacent to the cancer, where existed 56% of dysplasia and 40% of metaplasia, and no reaction in the tissues without dysplasia or metaplasia. But there was 4% of weak positive staining in normal tissues that were more than 5 cm beyond the. cancer. We conclude that tumor-associated antigen MG, is a useful marker for diagnosis of gastric cancer and detection of precancerous condition.

The effects of TDP radiation and infrared rays on the erythroblastic cells of the bone marrow were studied and compared in mice irradiated with gamma rays from a 60Co sourse. The rate of 58Fe-citrate incorporation and other parameters were determined.It was found that the 59Fe incorporation rate, the number of uncleated cells, the mitotic index, the labelling index, and the labelled mitotic index in the bone marrow of the mice of TDP irradiated group were significantly higher than those of the control(P0.05). Ont he basis of the results, it might be concluded that TDP radiation can promote the synthesis of corpuscular hemoglobin, which in turn accelerates erythropoiesis.

Objective: To explore the expression of serum levels of platelet activating factor (PAF) and its correlation to the property of coronary plaque in patients with different types of coronary artery disease (CAD). Methods: A total of 138 patients received coronary angiography (CAG) in our hospital from 2013-01 to 2013-12 were studied. According to CAG and clinical presentation, the patients were divided into 3 groups: Control group, the subjects with normal coronary artery, n=33, ACS (acute coronary syndrome) group, n=65 and SAP (stable angina pectoris) group, n=40. Serum levels of PAF were detected by ELISA, coronary lesions were examined by intravascular ultrasound (IVUS), and the correlation between PAF levels and plaque properties were studied. Results: ① Compared with Control group, ACS group and SAP group had increased serum levels of PAF; PAF level in ACS group was even higher than SAP group, both P<0.05. ② IVUS examination indicated that there were 30/40 (75.0%) patients with hard plaque in SAP group and 44/67 (67.7%) patients with soft plaque in ACS group. Compared with SAP group, ACS group were mainly having eccentric plaques and increased rates of plaque rupture (24.6% vs 7.50%), thrombus formation (21.5% vs 0%), plaque positive remodeling (46.1% vs 25.0%) and eccentric index (0.70 ± 0.22) vs (0.30 ± 0.24), all P<0.01;the external elastic membrane area was similar between SAP group and ACS group, P>0.05. ③ PAF levels were similar in fibrous, calcified and mixed plaques, P>0.05; while they lower than that in soft plaque, P<0.05. Conclusion: ① Serum PAF was involved in coronary plaque formation, unstable plaque usually had the higher PAF level.② PAF level may provide a new reference for ACS diagnosis, treatment and prognosis.

Urinary incontinence is an important predictive indicator for death and bad prognosis in stroke patients. Based on clinical advances in acupuncture-moxibustion treatment for post-stroke urinary incontinence, this article has found that present studies on acupuncture-moxibustion treatment for post-stroke urinary incontinence are basically related to clinical research. The study on the mechanism of acupuncture-moxibustion treatment for post-stroke urinary incontinence remains to be further deepened.