Hemodynamic monitoring is a very important measure for critically ill patients with burn and trauma, and it should be carried out throughout the course of treatment. Functional hemodynamic monitoring consists of the assessment of the dynamic interactions of hemodynamic variables in response to a defined volume change. Accordingly, response of fluid volume can be assessed in a quantitative fashion by measuring variation of both arterial pulse pressure and left ventricular stroke volunime during positive pressure breathing, or the change in cardiac output response to passive leg raising maneuver. Functional hemodynamic monitoring, contrary to that of static condition in order to realize dynamic and individual monitoring, is related to response to treatment, and it is a useful complement to static (routine) hemodynamic monitoring. At present, in the care of sepsis, shock, and mechanical ventilation, etc. related to burn injury and trauma, functional hemodynamic monitoring is more and more accepted and applied by medical personnel of ICU in burn and trauma departments. Therefore, further study on functional hemodynamic monitoring should be emphasized and practised.
Blood Pressure ; Burns ; therapy ; Critical Care ; Critical Illness ; Fluid Therapy ; Hemodynamics ; physiology ; Humans ; Positive-Pressure Respiration ; Respiration, Artificial ; Sepsis ; diagnosis ; therapy ; Shock ; diagnosis ; therapy ; Stroke Volume ; Systole

Animals ; Communicable Diseases ; epidemiology ; Disasters ; Earthquakes ; Humans ; Risk Assessment

Objective To set up a new method of mild hypothermia via lateral ventricle in rabbits following traumatic brain injury (TBI). Methods Twenty-one New Zealand rabbits were used for this study. TBI was pro- duced with all the rabbits in anesthesia by using free-falling impact model. Animals were randomly divided into three groups: a TBI group, a mild hypothermia group (by perfusion of 25℃Ringer's solution via the lateral ventricle) and a control group. The contents of water and total sodium, potassium of the brain region close to traumatic brain tissue were detected and pathological changes were observed in three groups. Results The number of the injured neurons was increased significantly in both TBI group and mild hypothermia group than that in control group at 72 h after TBI (P

Drugs, Chinese Herbal ; chemistry ; Humans ; Isoflavones ; isolation & purification ; pharmacology ; Phytoestrogens ; Plant Preparations ; isolation & purification ; pharmacology ; Plants, Medicinal ; chemistry ; Platelet Aggregation Inhibitors ; isolation & purification ; pharmacology ; Pueraria ; chemistry ; Scutellaria baicalensis ; chemistry

Objective To evaluate whether High-Dose folic acid supplementation may improve endothelial function in patients with coronary artery disease undergone interventional therapy. Methods Forty six patients with coronary artery disease and undergone interventional therapy were divided into two groups: 23 with folic acid supplement (20 mg/d) and 23 Patients without folic acid as the controls for 6 months. Plasma homocystine (Hcy) was measured by fluorescence polarization immunoassay and Flow-mediated endothelium-dependent dilation (FMD) of the brachial artery was assessed by high resolution ultrasound before and after 6 months. Results Compared with the control, folic acid supplementation resulted in lower plasma Hcy levels (8.82?3.32 ?mol/L vs 13.16?5.06 ?mol/L, P

0.05). The incidence of anastomotic leakage in the control group (16.7%) was higher than that of the study group (4.3%). The area of collagen fibrils 3 d, 5 d and 7d after intestinal anastomosis in the study group were significantly more than that in the control group ( P

Objective To report the clinical effects of repairing skin defects in hand by reversed neu- ro-veno-fasciocutaneous flaps based on the superficial branches of radial nerve.Methods Eleven cases with soft tissue defects around the wrist and the dorsum of the hand were treated with superficial branches of radial nerve-cephalic vein neuro-veno-fasciocutaneous flaps.Results The flaps totally survived in the 9 cases,the others were small distal necrosis.Follow-up survey in the(6-48)months after the oporation showed the appear- ante and function were satisfactory.Conclusion Superficial branches of radial nerve neurofasciocutaneous flap is well supplied with blood and easy to perform.It is the ideal flap to repair the skin defects of the first finger web,radial palm and dorsum of hand.

Objective: To research the adsortpion and separation function of ion-exchange resin on 5-hydroxytryptophan (5-HTP) in extract from the seeds of Griffonia simplicifolia and to screen the ion-exchange resin with high selective adsorption. Methods: The static adsorptive properties of eight different types of ion-exchange resins were evaluated using adsorptive content, desorption rate, adsorption rate, and adsorption temperature as indexes in order to optimize the resin. And the effects of different pH values, injection rates, injection concentration, eluent concentration, and elution rates on adsorptive properties of resins were investigated. Results: The 001 × 7 cation exchange resin showed the best comprehensive adsorption property. The loading solution concentration was 10.8 mg/mL, the pH value was 3.5, the flow rate of loading solution was 4.0 mL/min, and 3BV 7.0% ammonia water solution in 3.0 mL/min velocity was used to elute. In this process, the product was obtained with the 5-HTP purity of greater than 99.0% and the ash content of less than 1.0%, product average yield was 7.95% and the product quality could meet the market demand. Conclusion: The 001 × 7 cation exchange resin shows a better comprehensive adsorption property. It could be used to isolate and purify the 5-HTP for scale production.

Objective: To optimize the technological parameters of separation and purification of cynarin from Cynara scolymus leaves. Methods: Seven different types of macroporous adsorption resins were evaluated on absorptive capacity, desorption rate, and adsorption rate in order to select the best resin and the conditions of the best resin to separate and purify cynarin were researched. Results: It was found that LSA-21 resin showed better comprehensive adsorption property, flow rate of sample loading was 2 BV/h, 3 BV/h 50% alcohol aqueous and 2 BV/h velocity was used to elute. In this process to obtain the product with purity of 5.63% cynarin, ash content of 0.61%, product yield 5.56%, the product quality could meet the market demand. Conclusion: The LSA-21 macroporous adsorption resin shows better comprehensive adsorption property. It could be used to isolate and purify the cynarin.

Objective: To explore a new evaluation method for hospital intangible assets through a case study on evaluation of hospital "Know-how". Methods: Using the contingent valuation method(CVM) we designed a questionnaire to survey the willingness of patients to pay for hospital "Know-how". The data was analyzed by econometrics methods and a model was established for evaluating the "Know-how" in hospitals. Results: Under three scenarios, the effect of "Know-how" increased gradually; the percentages of patients who were willing to pay were 58.48%, 65.50% and 98.54%, respectively. The mean maximal payments were 4,5,and 5 folds that of the basal level. The annual family income was the most important factors influencing the patients' willingness to pay. According to the model established,the value of the hospital "Know-how" was between 85.014 95 million to 252.229 million RMB in 2006. Conclusion: CVM may serve as a new method to evaluate hospital "Know-how" and should be further studied in the future.