OBJECTIVE:To investigate the economic effects of two azithromycin therapeutic schemes for lower respiratory tract infections(LRTI).METHODS:45cases of LRTI collected from this hospital were divided into two groups:iv azithromycin group and iv oral sequential azithromycin group.Clinical effect was observed and cost-effectiveness analysis was carried out.RESULTS:The total costs were415.00yuan and260.08yuan(P0.05)in iv azithromycin group and iv oral sequential group respectively.CONCLUSION:The iv oral sequential azithromycin scheme is better one for treating LRTI.