Objective 22q11 microdeletion is featured with hemotological dysfunction,among others:hypocalcemia,thrombocytopenia and megathrombocyte.This study was trying to work out the platelet characteristics of 22q1 1 microdeletion patients and its potential clinical application.Methods A total of 80 cases who had undergone open-heart surgery were selected and confirmed with fluorescence in situ hybridization (FISH) to have 22q1 1 microdeletion among 40 cases while the others were negative.The relevant data in full blood routine of all the 80 cases in hospital information system (HIS) then were collected and analyzed with suitable statistical methods.Results The mean platelet volume in microdeletion group was statistically higher than that in the control group [(11.20 ± 1.94)fL vs (8.95 ± 1.58) fL,P ＜0.01].The area under the receiver operating characteristic (ROC) curve was 0.82,meaning significant predictive values.The corresponding sensitivity and specificity for mean platelet volume (MPV) =10 fL were 70.0 ％ and 80.0 ％,respectively.Conclusions MPV in congenital heart defect patients with 22q11 is significantly higher than those without 22q11.It is an effective method for preliminary screening 22q11.Being obtained from full blood routine data,it is economic and quick.MPV =10 fL can be used as a cutoff for guidance for irradiated blood transfusion postoperatively.

Based on the first hand cardiothoracic surgical training experiences in Australia, the author introduced the Australian surgical training system's objective, structure, outline and specific training methods as well as its contents in detail. Its overall characters can be summarized as high standard, strict requirement and equal stress on both theory and practice. Hopefully, this introduction and reflection may shed some light on the improvement and evolvement of the resident training system in China.

Objective To identify the relations of secondary cerebral edema volume with aquaporin 4 (AQP4) and reactive oxygen species (ROS) levels in patients with spontaneous deep supratentorial intracerebral hemorrhage. Methods Forty-seven patients with spontaneous deep supratentorial intracerebral hemorrhage, admitted to our hospital from December 2016 to January 2018, were chosen in our study; on the 1st, 3rd, 14th and 28th d of onset, the hematoma volume and secondary cerebral edema volume were measured by CT scan. Serum AQP4 and ROS levels were measured by ELESA. The relations of perihematomal edema volume with AQP4 and ROS levels in patients with spontaneous deep supratentorial intracerebral hemorrhage were analyzed. Results The hematoma volumes on 14th and 28th d of onset were significantly decreased as compared with those on 1st and 3rd d of onset (P<0.05); the serum AQP4 and ROS levels gradually increased on 1st, 3rd, and 14th d of onset, with significant differences (P<0.05). The cerebral edema volume, and serum AQP4 and ROS levels on 28th d of onset were significantly decreased as compared with those on 3rd and 14th d of onset (P<0.05). Serum AQP4 and ROS levels were positively correlated with cerebral edema volume (r=0.331, P=0.000;r=0.541, P=0.000); serum ROS level was positively correlated with AQP4 level (r=0.298, P=0.000). Conclusion The changes of brain edema volume, and serum AQP4 and ROS levels in patients with spontaneous supratentorial intracerebral hemorrhage are consistent and positively correlated, which suggests that the antioxidant may reduce the AQP4 protein expression, reduce the degree of brain edema, and alleviate the deterioration of patients with spontaneous intracerebral hemorrhage.