Objective To analyze the correlation between the principal components of TCM symptoms and the quality of life of the middle-advanced stages lung cancer patients. Methods 176 lung cancer patients of the middle and advanced stages were collected, and their principal components of TCM symptoms were abstracted, and then the representative correlation analyses between the principal components and the quality of lives was made. Results There were two kinds of principal components of TCM syndromes. One was Qi and blood deficiency, phlegm and blood stasis, and water stasis;the other was Qi and blood deficiency. There was significantly negative correlationship between Qi and blood deficiency and GH, MH, RE, BP. Conclusion The principal components of TCM syndromes were consistent with the TCM thesis. And there was a significantly negative correlationship between the principal components of TCM syndrome and patients’ quality of life.