Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-age women, affecting an estimated 5-8% of all women in this age group. Clinically, hyperandrogenism, chronic amenorrhea, central obesity and polycystic ovary can all occur in women with PCOS and may cause of infertility. Dehydroepiandrosterone sulfate is an androgenic hormone produced inadrenal cortex and recently, there is no any data determined DHEA-S in patients with PCOS.Our study was designed to evaluate obesity, central obesity, hirsute grade and infertility and to determine serum DHEA-S hormone in women with PCOS and healthy non-PCOS women.We have used a cross-sectional study design and the study included reproductive-age 36 women, of whom 18 were diagnosed with PCOS and 18 were non-PCOS. Anthropometric components were measured and ELISA test to determine serum DHEA-S hormone was analyzed for all of these women. When we analyzed ELISA test to determine serum DHEA-S hormone, DHEA-S level was2.9±2.0 µg/ ml in non-PCOS reproductive-age women and 8.0±2.1 µg/ml in women with PCOS, respectively (р=0.01). Among the women diagnosed with PCOS had higher incidence of central obesity and grade II hirsute and infertility than healthy women (p=0.001). By the result, higher level of serum DHEA-S in women diagnosed with PCOS may cause of sign of hyperandrogenism such as central obesity, infertility and hirsute.

IntroductionPolycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-age women,affecting an estimated 5-8% of all women in this age group. Clinically, hyperandrogenism, chronicanovulation, central obesity and polycystic ovary can all occur in women with PCOS and may causeof infertility. Dehydroepiandrosterone sulfate is an androgenic hormone which produced from adrenalcortex and recently, there is no any data determined DHEA-S in patients with PCOS.GoalOur study was designed to determine serum DHEA-S and other hormones in women with PCOS.Materials and MethodWe have used a cross-sectional study design and the study included reproductive-age 18 women withPCOS. ELISA test to determine serum DHEA-S and other sexual hormones was analyzed for all of thesewomen.ResultWhen we analyzed ELISA test to determine serum DHEA-S and other sexual hormones, DHEA-S level8.0±2.1 μg/ml, LH level 9,45±4,3 mlU/ml, FSH level 5,04±1,1 mlU/ml, prolactin level 19,78±12,2 ng/ml, E2 hormone level 16,8±8,9pg/ml, testosterone level 0,25±0,1 ng/ml were in women with PCOS,respectively. And LH/FSH ratio was 2:1 in these women. (p=0.001).ConclusionBy the result, serum DHEA-S, LH,

Introduction: In 2007, ” National innovation Development Program in Mongolia” was adopted by 306th act of Mongolian government and indicated that its important to focus attention to research outcomes become real productions based on scientific knowledges, experiences, skilled personnel and possibility of laboratory and production. In Mongolian and Tibetan traditional medicine have been used many herbal and animal preparations has biological active compound with anti inflammatory effect for the treatment of wound healing and ulcer. One of them, Cacalia hastata L. is a medicinal plant, which is widely used for the treatment of wound healing, cholangitis and gastroduodenal ulcer in the Mongolian and Tibetan traditional medicine. It is appropriate to prepare film coated tablet for the treatment of gastric and duodenal ulcer, gel for the treatment of wound healing. Purpose: To prepare film coated tablet for the treatment of gastric and duodenal ulcer, gel for the treatment of wound healing from semi-solid extract of Cacalia hastata L. and determine their quality criteria. Material and methods: Herb of Cacalia hastata L. was collected as a raw material from Terelj in July 2009; from Batsumber soum, Tuv aimag province in July 2010, 2011. For determining of quality of semi-solid extract and new drug formulations were evaluated biological activity compounds such as alkaloid, carotenoid and flavonoid by spectrophotometric method. We prepared film coated tablet by wet granulation and film coating method and gel by dispersion method. Tests for significant differences between means were performed by one sample t-test and One way ANOVA using the software SPSS 16. Differences were considered significant at p<0.05. Results: We prepared tablet from semi-solid extract of Cacalia hastata L. For preparing the film coated tablet used mixture solution of 8 % gelatin and 6 % sodium carboxymethylcellulose as a binder, sodium carbonate as diluents. The tablet was coated 5% solution of hydroxypropylmethylcellulose with 10 % polyethyleneglycol as a film former used traditional coating pan. Film coated tablet was standardized by such criteria, as appearance (colour, smell), the average weight, amount of biologically active compound, hardness, disintegration, dissolution and bacterial contamination. We prepared Cacalia gel from semi-solid extract of Cacalia hastata L. using various excipients and determined quality criteria, developed technological scheme of preparing. Gel was standardized by such as criteria: appearance (color, smell), the amount of biologically active compound, pH, viscosity, spreadability, extrudability and bacterial contamination. Conclusions: 1. Developed technology of preparing 0.3 gram film coated tablet from semi-solid extract of Cacalia hastata L. and determined quality criteria. 2. Developed technology of gel from semi-solid extract of Cacalia hastata L. and standardized its quality.

Introduction: During this pandemic, overcrowding in classroom caused by a lack of educational facilities and poor indoor air quality are the main causes of respiratory diseases among children and adolescents. Therefore, it is essential to measure and assess the indoor air quality where children spend extended periods of time such as school. Materials and methods: This study covered four schools with old buildings and four schools with new buildings in Bayanzurkh, Sukhbaatar, Khan-Uul, Chingeltei district of Ulaanbaatar. We collected PM10 and PM2.5, carbon dioxide, air temperature, humidity, and microbiological count from chosen classrooms and compared to the MNS4585:2016 standard. SPSS-24 was used to do statistical analysis on the information gathered during the evaluation. Results and Discussion: The 24-hour average PM2.5 concentration was 64.3 (95% CI: 64.1-64.5) mcg/m3, which was 4.3 times higher than the WHO guideline value and 1.3 times higher than the MNS4585:2016 standard. The 24-hour average PM10 concentration was 85.3 (95 % CI: 85.1-85.6) mcg/m3, which is 1.9 times higher than WHO guideline value. In older school buildings, the 24-hour average PM2.5 concentration was 5.6 times higher than the WHO guideline value and 1.7 times higher than the MNS4585:2016; the average PM10 concentration was 2.8 times higher than the WHO guideline value and 1.3 times higher than the MNS4585:2016. The air temperature and carbon dioxide concentration in classroom was met the MNS4585: 2016. The average relative humidity of all schools is 24.2±6.5%, which is 14-16% lower than the MNS4585: 2016. Conclusion The indoor air quality of the school in new and old buildings was similar poor, therefore a variety of steps are needed to improve it.