According to the China cardiovascular disease report in 2015,cardiovascular disease is the leading cause of death in China.In view of the grim situation of prevention and control of cardiovascular disease in China,and implement with the spirit of National Science and Technology In novation Conference and National Health Conference in China recently,the author analyzed the current status of prevention and control of cardiovascular disease as well as the basic research situation,and discussed the leading role of National Natural Science Foundation of China in promoting the basic research of cardiovascular disease in China.

The effects of Verapamil ( Ver ) . Aspirin ( ASA ) and ASA+ Ver on platelet aggregation and generation of thrombosis were studied. ASA and Ver inhibited rabbit platelet aggregation in vitro and rat platelet aggregation in vivo induced by ADP, also prolonged the occlusion time of thrombosis that was induced electrically in the carotid artery of the rat, and reduced the death rate resulted from pulmonary thrombosis that was induced with inducer composed of collagen and epinephrine iv in mice. The effects of Ver and ASA were markedly increased when combined, meanwhile all showed good dose-dependant manner.

Methods:To describe the connotation and construction mechanism of integrated medical service system.Methods:Based on the data of hierarchy diagnosis situation in China Statistical Yearbook from 2005 to 2015,the traditional medical service system and integrated medical service system were compared from the objective,method and core,while the construction mechanism of integrated medical service system was analyzed from the lead,control,supervision and adjustment.Results:Under the background of Health China,integrate medical system based on the purpose of health community,the method of division and cooperation and the core of cost management was different from the traditional medical service system which based on the aim of medical service,the method of competition and split and the core of ‘business of water'.Hierarchy diagnosis was the appearance/mehod of regional integrated diagnosis and the result from medial resource optimized allocation under the integrated medical service system.Constructing the integrated medical service system was the basic demand of medicine and health system reform.Conclusion:Constructing the integrated medical service system should be led by the performance appraisal of medical institutions,controlled by the cost accounting and adjusted by medical service prices,so that to make the benefits for the demander,the provider and the third party of medical service system to construct and share the health community.

Objective: This study aims to analyze the outpatient prescriptions in primary rural health institutions in western China to reveal the feature and disadvantages of utilization of Chinese patent medicines in rural areas.Methods: A total of 14336 prescriptions were selected from 132 health institutions in rural areas of 7 provinces in western China in 2011.The utilization of Chinese patent medicines is described and compared to the health institutions in different levels and different provinces/autonomous regions.Results: The prescriptions of Chinese patent medicines accounted for 62.47% of the total prescriptions in rural health facilities.The proportion of county, township and village medical institutions was 49.76%, 56.96% and 71.51% respectively.86.84% of the Chinese patent medicines prescriptions were prescribed by physicians without traditional Chinese medicine background, while only 13.16% of them were traditional Chinese medicine physicians.The number of varieties of Chinese patent medicines in a single prescription in county, township and village health institutions were 1.38, 1.91 and 2.54, respectively and the average drug costs of every prescription in these health institutions were 52.20 yuan, 21.89 yuan and 19.37 yuan, respectively.Conclusions: There are differences in the utilization of Chinese patent medicines in outpatient prescriptions of rural health institutions in western China.The hospitals in higher medical level use more Chinese patent medicines.The drug cost of the prescription of county health institutions is higher than that of township and village hospitals.This study suggests that health policy should be adjusted based on the specific needs and characteristics of rural health institutions at a different level and should be implemented in the management of prescription in quality control.

Objective To study T lymphocyte subsets levels in acute zoster patients and investigate its relation to the zoster associated pain.MethodsAccording to the visual analogue scales(VAS) in the acuter phase, 60 patients with herpes zoster were divided into two groups: group A (VAS≤6) and group B (VAS＞6). According to the follow-up results, patients were divided into another two groups: group C (PHN not developed) and group D (PHN developed). 25 healthy volunteers with a similar age and gender range as the patients were recruited as control group. T lymphocyte subsets were detected by fluorescence-activated cell sorter (FACS). ResultsThere was no significant difference in gender and age between groups (P＞0.05). T lymphocyte subsets were significantly decreased in four groups compared with the control group (P＜0.05), and the CD4 +subsets in group B were significantly decreased compared with group A (P＜0.05). The CD4 +/CD8 + ratios were significantly higher in group A and C than in control group, higher in group A than B and higher in group C than in group D (P＜0.05). The visual analogue scales(VAS) in group D were significantly higher than in group C (P＜ 0.05).Conclusions Cellular immunity function is decreased with the lower percent of the T lymphocytes subsets in the elderly patients with acute herpes zoster, especially in severe patients. The CD4 +/CD8 + ratios and the visual analogue scales may be associated with the the risk of post herpetic neuralgia.

ObjectiveTo investigate the effects of selective lobar ventilation on intrapulmonary shunt and inflammatory response in patients with pulmonary dysfunction during thoracotomy.MethodsThirty-four ASA Ⅱ or Ⅲ patients,aged 64-79 yr,weighing 50-85 kg,with moderate and severe impaired pulmonary function,scheduled for esophageal cancer radical correction,were randomly divided into 2 groups( n =17 each): one-lung ventilation group (group A) and selective lobar ventilation group (group B).In group A,endobronchial blocker tube was used to obstruct bronchus principalis and practice one-lung ventilation.In group B,endobronchial blocker tube was used to obstruct bronchi lobares and practice selective lobar ventilation.The blood samples were taken from arteria radialis and internal jugular vein for blood gas analysis and determination of the plasma concentrations of TNF-α,IL-6 and IL-8 by ELISA before anesthesia induction(T0 ),at 30 min following two-lung ventilation at lateral position (T1),at 60 min following one-lung ventilation or selective lobar ventilation (T2) and at the end of surgery (T3).Ppeak and Plat.were recordeded at the same time.ResultsThe incidence of hypoxemia was significantly lower in group B (0) than in group A(18％ )( P ＜0.05).Compared with group A,Pplat and Ppeak at T1-3,Qs/Qt at T2,TNF-α,IL-6 and IL-8 concentrations at T2-3 were significantly decreased in group B( P ＜ 0.05 ).Conclusion The selective lobar ventilation can reduce intrapulmonary shunt,inhibit inflammatory response to help lessen mechanical ventilation related lung injury during thoracotomy in patients with pulmonary function.

adrenergic receptor is the third subtype of ?-adrenergic receptors. The genetic structure and pharmacological property of ? 3-adrenergic receptor are markedly distinguished from ? 1-and ? 2-adrenergic receptor subtypes. Recently studies show that myocardial ? 3-adrenergic receptor mediates negative inotropic effect through Gi-protein/NO/cGMP pathway, the expression of ? 3-adrenergic receptor and negative inotropic effect mediated by ? 3-adrenergic receptor are increased in heart failure. However, because of the low expression of ? 3-adrenergic receptor in the heart, the actual pathophysiological significance of ? 3-adrenergic receptor remains unknown.

Objective To investigate the effects of selective lobar ventilation on intrapulmonary shunt and inflammatory response in patients with pulmonary dysfunction during thoracotomy.Methods Thirty-four ASA Ⅱ or Ⅲ patients,aged 64-79 years,weighing 50-85 kg,with moderate or severe impaired pulmonary function,scheduled for esophageal cancer radical correction,were randomly divided into two groups (n =17 each):one-lung ventilation group (group A) and selective lobar ventilation group (group B).In group A,an endobronchial blocker tube was used to obstruct the bronchus principalis and practice one-lung ventilation.In group B,an endobronchial blocker tube was used to obstruct the bronchi Iobares and practice selective lobar ventilation.Blood samples were taken from the arteria radialis and the internal jugular vein for blood gas analysis and determination of plasma concentrations of tumor necrosis factor-alpha (TNF-α),interleukin-6 (IL-6) and IL-8 by enzyme linked immunosorbent assay (ELISA) before anesthesia induction (T0),30 minutes following two-lung ventilation at the lateral position (T1),60 minutes following one-lung ventilation or selective lobar ventilation (T2) and at the end of surgery (T3).Peak airway pressure (Ppeak) and plateau airway pressure (Pplat) were recorded at the same time.Results The incidence of hypoxemia was significantly lower in group B (0) than in group A (18％,P ＜ 0.05).Compared with group A,Pliat and Ppeak at T1-3,the intrapulmonary shunt rate (Qs/Qt) at T2,TNF-α,IL-6 and IL-8 concentrations at T2-3 were significantly decreased in group B (P ＜ 0.05).Conclusion Selective lobar ventilation can reduce intrapulmonary shunt and inhibit inflammatory responses to help lessen mechanical ventilation-related lung injuryduring thoracotomy in patients with pulmonary dysfunction.

ObjectiveTo enhance the fund efficiency of dental research programs supported by National Natural Science Foundation (NSFC) and to reveal the achievements and progresses of the funds.MethodsThe data of programs in dental and craniofacial field supported by NSFC from 1999 to 2006 and completed between 2003 and 2009 were collected based on the final reports by the investigators.The data of personnel training,research publication,patent,awards,and academic communication at domestic and international levels were all collected and analysed. Results There were 307 grants in total,including 185 general programs,73 Young Scientists Funds,13 regional funds,3 Key Programs,1 National Science Fund for Distinguished Young Scholars and 32 others.An average of 4 postgraduate students was trained by each program.In general,the outcomes of general programs were better than those of Young Scientists Fund,and the latter was better than regional fund.There was steady increase each year in the amount of papers published in SCI journals,and about half of the investigators published SCI papers.In addition,9 patents were registered and 13 prizes were won, and the investigators participated 610 domestic and international exchanges.Conclusions The continuously increase of NSFC support in dental field has led to substantial achievement,although patent application,the quality of papers and novel ideas need to be improved.

China ; Cohort Studies ; Humans