7.Research Progress of m6A-Methylation in Acute Leukemia-Review.
Qiu-Ni CHEN ; Yue CHEN ; Ting-Ting JI ; Liang YU
Journal of Experimental Hematology 2019;27(6):2014-2018
Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies, especially acute leukemia (AL). Similar to DNA methylation and histone modifications, RNA methylation is another important epigenetic modification. m6A methylation is one of the most prevalent and extensively studied RNA methylation. m6A methylation is involved in many biological and pathological process. Recent studies have found that m6A methylation is involved in the occurrence, development and drug-resistance of AL. This review focuses on the research progress of m6A methylation in AL.
DNA Methylation
;
Epigenesis, Genetic
;
Humans
;
Leukemia
8.Let -7i : A key player and a promising biomarker in diseases.
Journal of Central South University(Medical Sciences) 2023;48(6):909-919
MicroRNAs (miRNAs) are endogenous non-coding single-stranded small RNAs that regulate gene expression by recognizing homologous sequences and interfering with transcriptional, translational or epigenetic processes. MiRNAs are involved in a variety of disease processes, and regulate the physiological and pathological status of diseases by modulating target cell activity, migration, invasion, apoptosis, autophagy and other processes. Among them, let-7i is highly expressed in various systems, which participates in the process of tumors, cardiovascular and cerebrovascular diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases and other diseases, and plays a positive or negative regulatory role in these diseases through different signal pathways and key molecules. Moreover, it can be used as an early diagnosis and prognostic marker for a variety of diseases and become a potential therapeutic target. As a biomarker, let-7i is frequently tested in combination with other miRNAs to diagnose multiple diseases and evaluate the clinical treatment or prognosis.
Biomarkers
;
Apoptosis
;
Autophagy
;
Epigenesis, Genetic
;
MicroRNAs/genetics*
Result Analysis
Print
Save
E-mail