Objective To investigate the clinical significance and level variation of serum CA125 in patients with endometriosis.Methods Serum CA125 level of 28 recurrent cases,76 endometriosis cases and 80 healthy cases were retrospectively analyzed.Results In 76 endometriosis cases,the level of serum CA125 of 42 cases was over 35 kU/L,the sensitivity was 55.2%,the sensitivity of stage Ⅲ-Ⅳ(64.8%) was obviously higher than that of stage Ⅰ-Ⅱ (45.6%);In 28 recurrent cases,the values of serum level CA125 of 20 cases were over 35 kU/L,the sensitivity was 71.4%,and the prediction ability of CA125 in stage Ⅲ-Ⅳ(93.7%) was obviously higher than that in stage Ⅰ-Ⅱ (41.6%).Conclusion Serum CA125 played an important role in the diagnosis and prediction of endometriosis.

The process of lung cancer invasion and metastasis consists of a complex series of multigene and multistep, CD44V6 is a broadly distributed transmembrane glycoprotein, which mainly participates in the specific adhesion process and plays an important role in cell-cell and cell-matrix interactions.The researches showed that the high expression of CD44V6 was helpful for metastasis ability of tumor cell. MMps is a groups of metal hydronium depend-proteinase, it exhibits proteolytic activity against components of the extracellular matrix (ECM). The recent study indicated that MMps has been played important roles not only in degradation of ECM proteins, but also in the regulation of tumorigenesis. Combined with two marker might be an important significant to judge prognosis ,metastasis and development.