Objective　To investigate the correlation between serum uric acid,high sensitive C-reactive protein (hs- CRP),matrix metalloproteinase-9 (MMP-9) and the incidence and prognosis of elderly patients with acute cerebral infarction.Methods　Seventy-three elderly patients with acute cerebral infarction admitted to our hospital from June 2020 to September 2021 were selected as the observation group,and 50 healthy elderly patients examined in our hospital at the same time were selected as the control group.The levels of serum uric acid,hs-CRP and MMP-9 were compared between the two groups.The patients were divided into mild group,moderate group and severe group according to the score of stroke scale (NIHSS).The levels of serum uric acid,hs-CRP and MMP-9 were compared and the correlation was analyzed.The patients were divided into good prognosis group and poor prognosis group according to the neurological deficit score (mRS).The levels of serum uric acid,hs-CRP and MMP-9 were compared and the correlation was analyzed.Results　The levels of serum uric acid,hs-CRP and MMP-9 in the observation group were significantly higher than those in the control group (P<0.05).The levels of serum uric acid,hs-CRP,MMP-9 and NIHSS score in severe group were significantly higher than those in mild and moderate groups (P<0.05).The levels of serum uric acid,hs-CRP,MMP-9 were positively correlated with NIHSS scores (P<0.05).The levels of serum uric acid,hs- CRP,MMP-9 and mRS score in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).The levels of serum uric acid,hs-CRP and MMP-9 were positively correlated with the mRS score (P<0.05).Conclusion　The serum uric acid,hs-CRP and MMP-9 levels in elderly patients with acute cerebral infarction were significantly increased on average,and were positively correlated with the severity of the disease,which could be used as a reference index for evaluating the condition and prognosis.