Objective To investigate the clinical treatment of brucellosis spondylitis (BS) through combination of Mongolian medicine and Western medicine.Methods From December 2010 to June 2015,51 patients which were diagnosed BS at the Department of Brucellosis Hulunbuir People's Hospital were enrolled in this study.After injecting etimicin sulfate and levofloxacin for two weeks,rifampin and doxycycline were administrated orally with Silver pearl pill,Pearl pill and Yunxiang pill (tid) for one treatment cycle which contained three courses of each treatment for 3 weeks.Before and after the treatment,the clinical features and imaging examination results were observed of 2 cases and then followed up for one year.Results Before the treatment,any spinal segment can be affected especially the lumbar spine.Two cases of cervical damage,5 cases of thoracic vertebrae,47 cases of lumbar spine,2 cases of sacral vertebrae,and 39 cases of vertebral abscess were found.After treatment,low back pain symptoms disappeared in 10 cases of the patients.Thirty-nine patients with low back pain symptoms and limited movement.Two patients with low back pain aggravated,MRI examination of the lumbar spine showed lesions increased and abscess formation.The effective rate of Mongolian herbal medicine and Western medicine treatment was 96.1％ (49/51).Conclusion The combined treatment of BS through combination of Mongolia medicine and Western medicine is effective.

Objective Study the epidemiological and clinical findings of patients with Brucellar epididymo-orchitis (BEO),to provide a theoretical basis for clinical diagnosis.Methods A study was carried out to analyze the patients' files of epidemiological,outcome,clinical and laboratory features of 23 cases of BEO and 185 in patients with brucellosis in Hulunbuir People's Hospital during 2011-2013.Results The age of patients with BEO and without epididymo-orchitis (EO) were (34.48 ± 10.32) years old and (42.07 ± 12.19) years old,the difference was statistically significant (t =-2.842,P ＜ 0.05).Patients with BEO and without EO of brucellosis patients with hypogastralgia ratio was 78.3％ (18/23) and 8.6％ (14/162),the difference was statistically significant (x2 =68.238,P ＜ 0.05).The proportion of BEO cases with abnormal White Blood of Cell (WBC) and C-reactive protein (CRP) levels were 34.8％ (8/23) and 91.3％ (21/23),which was significantly higher than those in without EO group [9.9％ (16/162),63.0％ (102/162),x2 =11.066,7.260,all P ＜ 0.05].After 2 to 7 days,BEO patients with scrotal swelling and pain and/or tenderness relieved.After two weeks treatment,11 patients of the urinary system showed normal by ultrasound,and no patients underwent testicular resection.Conclusions Young male patients with Brucellar are prone to BEO.Laboratory abnormalities are mainly leukocytosis and high CRP level.

Objective To analyze clinical and laboratory results of 38 children with brucellosis for providing theoretical basis for its clinical diagnosis and treatment. Methods The epidemiology, clinical features, laboratory characteristics and therapeutic effect of pediatric patients at HulunBuir People's Hospital from January 2011 to December 2015, were retrospectively evaluated. Results Totally there were 38 child patients with brucellosis, 24 males and 14 females, 36 children had directly contacted with animals, and onset seasons were mainly in Summer and Autumn. The dominant manifestations were fever in 33 (86.8%), anorexia in 21 (55.3%), arthralgiaand myalgia in 17 (44.7%), hepatomegaly in 5 (13.2%), splenomegaly in 11 (28.9%), and lymph nodes enlargement in 10 (26.3%). Abnormal laboratory findings included elevated C-reactive protein (CRP) level in 27 (71.1%) and erythrocyte sedimentation rates (ESR) in 24 (63.2%). Both the Rose Bengal test and serum agglutination test (SAT) were positive in 37 patients, only one patient was negative but the blood culture was positive. After at least 12 weeks of combined, adequate and standardized treatment, there were 30 pediatric brucellosis patients cured, improved in 8 cases, the total effective rate was 100.0%. Conclusions In endemic regions, the presence of persistent fever, joint pain and hepatosplenomegaly should alert clinicians the possibility of brucellosis. Early diagnosis and treatment will reduce the incidence of complications.

Objective:To investigate the clinical characteristics of patients infected with Brucella Melitensis ( B. Melitensis) type 1 and type 3 in Hulunbuir, Inner Mongolia Autonomous Region. Methods:A retrospective analysis method was used to collect clinical medical records of patients with brucellosis admitted to Hulunbuir People's Hospital from June 2013 to August 2017, and 71 patients with brucellosis positive in blood culture and identified by polymerase chain reaction (PCR) and AMOS-PCR were selected as the study subjects. According to the identification results, they were divided into B. Melitensis type 1 and type 3 groups. General information, epidemiological characteristics, clinical characteristics, laboratory examinations, complications and efficacy of the two groups were compared. Results:Among 71 patients with brucellosis, 22 cases were B. Melitensis type 1, including 16 males and 6 females, aged (39.91 ± 16.04) years old; 49 cases were B. Melitensis type 3, including 34 males and 15 females, aged (40.67 ± 18.72) years old. There were no significant differences in gender composition and age between the two groups (χ 2 = 0.081, t = 0.166, P > 0.05). There were 10 cases(45.5%) of B. Melitensis type 1 patients living in agricultural areas, 10 cases (45.5%) in pastoral areas, and 2 cases (9.1%) in cities; there were 40 cases (81.6%) of B. Melitensis type 3 patients living in agricultural areas, 7 cases (14.3%) in pastoral areas and 2 cases (4.1%) in cities, and the difference between regions was statistically significant (χ 2 = 9.276, P < 0.05). Testicular swelling and pain symptoms [22.7% (5/22), 6.1% (3/49)] in B. Melitensis type 1 and type 3 patients were compared, the difference was statistically significant (χ 2 = 4.187, P < 0.05); other clinical features were compared, the differences were not statistically significant ( P > 0.05). There were no significant differences in white blood cell count (WBC) and platelet count (PLT) decreased, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased between the two groups ( P > 0.05). The number of complications in B. Melitensis type 1 and type 3 patients were 12 cases (54.5%) and 14 cases (28.6%), respectively, and the difference between the two groups was statistically significant (χ 2 = 4.413, P < 0.05). Ten cases (45.5%) of B. Melitensis type 1 patients were cured, 12 cases (54.5%) were improved, 34 cases (69.4%) of B. Melitensis type 3 patients were cured, 15 cases (30.6%) were improved, and there were no invalid or relapsed patients in both groups, the difference in curative effect between the two groups was statistically significant (χ 2 = 3.690, P < 0.05). Conclusions:In Hulunbuir, Inner Mongolia Autonomous Region, there are differences in the living areas of B. Melitensis type 1 and type 3 patients. The B. Melitensis type 1 patients are prone to testicular swelling and pain and brucellosis complications.

Objective: To analyse epidemiological, clinical characteristics and laboratory examination results of 245 occupational brucellosis form 2008 to 2018, which providing theoretical basis for prevention and control of occupational brucellosis. Methods: Based on the China Center for Disease Control and Prevention Information System, a database of occupational brucellosis cases in HunlunBuir from January 2008 to July 2018 was established. The Epidemiological characteristics, Clinical manifestation, laboratory examination of 245 occupational brucellosis and 359 without occupational brucellosis were comparatively analyzed about the same period. Results: Among the 245 patients, 219 were males, 254 in 359, malese were significantly higher than control group (χ²=21.331, P<0.05) . Fever, fatigue, hyperhidrosis and splenomegaly are common in patients with occupational brucellosis and non occupational brucellosis. Arthralgia (54.3%/44.8%) and CRP (81.2%/71.3%) were significantly also higher than control group (χ²=5.193, P<0.05; χ²=7.704, P<0.05) Fever, hyperhidrosis, fatigue and splenomegaly were common clinical manifestation and signs in the two groups. Brucellosis can cause a variety of complications, including osteoarticular hematological system and hepatic involvement, some patients with multiple system damage. Conclusion The incidence of occupational brucellosis in HulunBuir is concentrated in agriculture and animal husbandry. Veterinarians are the main occupational groups, Occupational health interventions should be strengthened for key occupational hazards, regular occupational health examination, avoid chronic brucellosis and protect the health of key occupational groups.

Brucellosis is a common infection in many parts of the world.Neurobrucellosis is not a rare comolication of brucellosis with a broad spectrum of clinical manifestations.Patients with unkown neurological and psychiatric symptoms and persistent fever should be considered for neurobrucellosis in endemic regions.World health organization recommends doxycycline and streptomycin combined rifampicin/trimethoprim at least six to eight weeks.

Objective:To analyze the epidemiological characteristics, clinical features of brucellosis patients with abnormal blood routine, and to improve the awareness of brucellosis among clinicians.Methods:A total of 1 036 patients with brucellosis admitted to the Department of Brucellosis, Hulunbuir People's Hospital from January 2011 to December 2017 were selected, including 274 patients with abnormal blood routine (case group), and 762 patients with normal blood routine(conrtol group). Epidemiological characteristics, clinical features and laboratory tests were analyzed retrospectively.Results:In 274 patients of case group, there were 128 males and 146 females, and the age was (36.3 ± 18.7) years old. In 762 patients of conrtol group, there were 381 males and 381 females, and the age was (35.4 ± 20.4) years old, and there were no significant differences in sex ratio and age between the two groups ( P > 0.05). The main route of infection in the two groups was to raise livestock such as sheep and cattle, 254 cases (92.7%) and 724 cases (95.0%), respectively. The proportions of patients with dizziness symptoms were 31.0% (85/274) and 17.7% (135/762) in the two groups, and the proportions of patients with rash were 14.2% (39/274) and 3.0% (23/762), and the differences were statistically significant between the two groups (χ 2 = 21.331, 45.054, P < 0.05). The symptoms of fever, sweating and fatigue were common in both groups, and the splenomegaly was the most common sign. However, there were no significant differences in the proportion of abnormal characteristics between the two groups ( P > 0.05). Among the 274 patients in case group, 48 had leucopenia, 160 had anemia, and 148 had thrombocytopenia; and 17 had both leucopenia and anemia, 23 had both leucopenia and thrombocytopenia, and 16 had both anemia and thrombocytopenia, and 13 had leucopenia, anemia, and thrombocytopenia at the same time. Conclusions:In the brucellosis epidemic area, when the patient has symptoms such as fever, fatigue, sweating, leucopenia, anemia, and thrombocytopenia, and excluding abnormal blood routine caused by other reasons, clinicians should consider the possibility of Brucella infection.

Objective To analyze the epidemiological characteristics,clinical manifestations and laboratory examinations of occupational brucellosis (OB) in Hulun Buir City,Inner Mongolia,from 2008 to 2016,in order to provide experience for prevention and treatment of OB.Methods The data of human OB cases from 2008 to 2016 in Hulun Buir were extracted from the Chinese Information System for Diseases Control and Prevention (CISDCP).The available information included population distribution,geographical distribution,time distribution,occupational distribution,clinical manifestations and laboratory examinations of the cases.Results Of the 213 cases,191 were males and 22 females,aged from 23 to 62 years old,149 cases in their 25-44 years of ages among all age-gender groups,and 20.19％ of the cases (43) were reported in Ergun.Though occurred yearly and monthly,the disease reached the peaks in 2013 (41 cases),and in January (70 cases).A total of 212 cases had directly contacted with animals,only one was medical staff,116 were veterinary.The dominant manifestations were arthralgia and myalgia in 144 cases,sweats in 131,fatigue in 123,fever in 94 cases,splenomegaly in 17 cases,hepatomegaly in 4 cases,and hepatosplenomegaly in 2 cases.The positive rate of the Bengal plate agglutination test (RBPT) was 100％,standard tube agglutination test (SAT) title ≥ 1 ∶ 100 (++) in 195,and SAT title ≥ 1 ∶ 50 (++) in 18 cases.Abnormal laboratory findings included elevated C-reactive protein (CRP),aspartate transaminase (AST),and alanine aminotransferase (ALT) levels in 34,42 and 84 cases.Conclusions Occupational brucellosis is male-dominated,and concentrated in veterinary services.For exposed population,relevant departments should strengthen occupational health education,periodic occupational health examination.

Objective:To analyze the clinical characteristics of brucellosis complicated with rash.Methods:The medical records of 13 patients diagnosed with brucellosis complicated with rash diagnosed at the Hulunbuir People's Hospital from January 2017 to January 2022 were collected. Patient general information, clinical characteristics, laboratory tests and treatment results were analyzed by retrospective investigation.Results:Among the 13 patients with brucellosis complicated with rash, 10 were females and 3 were males, the youngest age was 39 years, and the oldest age was 62 years. All patients had fever, which may be accompanied by symptoms such as chills, fatigue, hyperhidrosis, arthralgia, headache and other symptoms. Among the 13 patients, 12 had scattered red or dark red macules/papules/maculopapules on the trunk and limbs, and 1 had red macules on both lower limbs, ranging in size from 2 to 10 mm, with no itching or pain symptoms, and the rash did not fade under pressure. All patients tested positive for rose bengal plate agglutination test (RBT) and in vitro serum agglutination test (SAT). Brucella was isolated and cultured from blood samples of 4 patients. All patients showed elevated levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), with detection values ranging from 27.1 to 146.4 mg/L and 22 to 79 mm/hr, respectively. Platelet and hemoglobin decreased in 1 case, 64 × 10 9/L and 96 g/L, respectively. Seven patients showed elevated levels of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST), with detection values ranging from 51 to 204 and 45 to 210 U/L, respectively. Creatinine increased in 2 patients, and the detection values ranged from 92.6 to 125.3 μmol/L. Three patients had abnormal urine routine; bone damage was found in 1 patient. After 12 weeks or more of combined, full dose and full course of drug treatment, 12 cases were cured and 1 case improved, with a treatment effectiveness rate of 100%. Conclusions:The incidence of brucellosis complicated with rash is low. When the patient has a history of epidemiological contact with brucellosis, and has symptoms of fever and rash, combined with laboratory test results, brucellosis can be considered, and early treatment could lead to a good prognosis.

Objective:To understand the clinical characteristics of Brucella epididym-orchitis (BEO). Methods:The clinical data of married male patients with brucellosis in acute stage admitted to Hulunbuir People's Hospital from September 2017 to October 2019 were collected and divided into BEO group and non-BEO group, with 46 and 50 cases, respectively. The clinical manifestations, laboratory examination and treatment effect were analyzed and evaluated.Results:The frequency of lower abdominal pain, erectile dysfunction and premature ejaculation in BEO group were higher than those in non-BEO group [26.1% (12/46) vs 8.0% (4/50), 89.1% (41/46) vs 12.0% (6/50), and 28.3% (13/46) vs 6.0% (3/50), χ 2 = 5.643, 57.037, 8.548, P < 0.05]. In laboratory examination, the incidence of increased leukocyte (WBC) count in BEO group was significantly higher than that in non-BEO group [23.9% (11/46) vs 8.0% (4/50), χ 2 = 4.602, P < 0.05]. In terms of sperm function, the incidence of decreased sperm dens (DENS) in BEO group was significantly higher than that in non-BEO group [21.7% (10/46) vs 2.0% (1/50), χ 2 = 9.201, P < 0.05]. After 2 - 7 d of treatment, the pain and/or tenderness of scrotum were relieved in all patients with BEO. After 3 - 5 d of treatment, the symptoms of BEO patients with lower abdominal pain and dysuria were relieved. After 12 weeks of treatment, 97.8% (45/46) of BEO patients had normal scrotal and testicular ultrasonography; 95.1% (39/41) of BEO patients had normal erectile function, 76.9% (10/13) of BEO patients had no premature ejaculation, and DENS returned to normal in 80.0% (8/10) of patients with DENS decreased. Five cases' sperm motility (PRNPPER) returned to normal of 6 patients with PRNPPER decreased. Conclusion:BEO patients have the clinical characteristics of lower abdominal pain, erectile dysfunction, premature ejaculation and spermatogenic dysfunction, and the overall prognosis is good after treatment.