Objective To investigate the efficacy of active immunization combined with dydrogesterone in the treatment of recurrent spontaneous abortion,and the expression of serum leptin(LP)and adiponectin(ADPN).Methods 51 cases of inpatient and outpatient treatment of repeated abortion of 51 pregnant women from January 2014 to December 2015 in Ningbo Fenghua People's Hospital of Zhejiang Province were selected,and 50 cases of normal pregnant women and normal nonpregnant women 50 cases as a control object.Depending on the treatment method,patients with recurrent spontaneous abortion were divided into combination group(n=26)and monotherapy group(n=25).The levels of LP,ADPN and β-HCG were measured before and after treatment,and the number of successful pregnancies.Results The levels of LP and ADPN in serum were measured in three groups of women,there were statistically significant differences between the two groups(P<0.05).The serum levels of β-HCG in the pregnant women with recurrent spontaneous abortion group were(3914.5±2548.2)mIU,and the normal pregnancy group was(7124.5±2847.6)mIU,the difference was statistically significant(P<0.05).After treatment,the levels of LP,ADPN and β-HCG in the combination group were significantly increased,and successful pregnancy as high as 88.46％,better than the level of monotherapy group,the difference was statistically significant(P<0.05).Conclusion Serum LP,ADPN lower levels of pregnant women prone to recurrent spontaneous abortion,through active immunization combined with dexamethasone treatment,can significantly improve the hormone level,improve the success rate of pregnancy.

OBJECTIVE: To present our experience of manipulation under general anesthesia for treating postoperative hip joint stiffness in children.METHODS: 193 children (226 hips) with postoperative joint stiffness were retrospectively studied at the Department of Pediatric Orthopaedics, Shengjing Hospital, China Medical University from January 1978 to December 2005, comprising 53 males and 140 females, aged 1-14 years old. 226 hips with postoperative stiffness from open reduction of developmental dysplasia of the hip (DDH) (155 cases with 188 hips) and capsulotomy for hip sepsis or tuberculosis (38 cases with 38 hips) were retrospectively reviewed. All patients laid on the surgical table supinately under general anesthesia. The assistant fixed the pelvic with palms. The operator manipulated the hip joint with 3 steps: flexed hip joint slowly and gently to 110°-120° or more; then abducted and externally rotated hip joint; adducted and internally rotated the hip. Then 3-step passive manipulation was repeated for once at least. As soon as the patient waked from general anesthesia, Continuous passive motion was applied for the affected hip with the range of motion increasing daily for 1-2 weeks. They were followed averagely 15 months (6-24 months) to evaluate the promoted range of motion in flextion-extension and adduction-abdduction.RESULTS: 186 hips (82.3%) succeeded in manipulation in addition to 34 failure hips (15%) and 6 hips (2.7%) with femoral neck fracture. The successful rate, promoted range of motion in group of ≤6-year-old and group of ≤12-month-duration from primary surgery were significantly higher, femoral neck fracture rate was less than those in group of >6 years of age and group of >12-month-duration from primary surgery.CONCLUSION: Passive manipulation under general anesthesia is a safe, uninvasive and effective method in treating postoperative hip stiffness in children. Younger age (≤6 years) and less duration from the primary surgery (≤12 months) would yield better result.