[Objective]Menstrual disorders are generic symptoms that appear during a menstrual cycle. In this study we examined three years of medical records retrospectively in order to investigate the effects of acupuncture treatment on menstrual disorders. We compared a group of women with diseases 'D'with to no diseases 'N'with respect to the effects of short-term acupuncture treatment.
[Methodology]Subjects for this research were 203women with menstrual disorders who came to our office during the period January 2009 -March 2012. The only treatment they were given was traditional Chinese medicine. We used BL 32, BL 35, GV 2, GV 4, and SP 6 as acupuncture points. We inserted stainless steel acupuncture needles (40 mm long, 1.8 mm in diameter) to a depth of 20 mm at BL 32 and 10 mm at SP 6. Other points were treated three times with kyubu-moxibution (burnt 90%). Treatment was provided once every 1-2 weeks. A Menstrual Distress Questionnaire (MDQ) was used to judge treatment effectiveness. We classified the 203women into two groups;one was 'D'group (n = 46) and the other was 'N'group (n = 157). Concerning the eight items from the MDQ we compared each woman's condition before the first treatment after one menstrual cycle. This time we paid attention to premenstrual and menstrual periods. 'D'group was observed through three menstrual cycles.
[Results]The average number of treatments during one menstrual cycle was 2.2. Both groups had reduced scores for 6 prementstrual symptoms (p < 0.05). During menstrual period, 'D'had reduced scores for 3items, 'N'had reduced scores for 5 items;(p < 0.05). 'D'confirmed continuous effects of treatment. The effects on premenstrual symptoms were confirmed, "Pain"during all three menstrual cycles, "Water retention"during the second and third menstrual cycles, and "Concentration"during the third menstrual cycle. The effects during the menstrual period were also confirmed, "Pain"for all three menstrual cycles, and "Water retention"and "Behavioral change"during the third menstrual period (p < 0.05).
[Discussion]Concerning the effects of acupuncture treatment for menstrual disorders, 'D'had higher MDQ scores than 'N'. After one menstrual cycle, 'D'showed less improvement of MDQ items than 'N'. But continuous acupuncture treatments reduced menstrual disorder symptoms for 'D'.
[Conclusion]We have confirmed the effects of acupuncture treatment on menstrual cycle symptoms. In one menstrual cycle, 'N'showed more improvement than 'D'. But during three menstrual cycles 'N'experienced continuous effects of treatment.

Purpose: Naldemedine is a peripheral µ-opioid receptor antagonist, including the treatment of opioid-induced constipation (OIC) . However, diarrhea is known as its side effect. We conducted a study focusing on the administration period of opioid analgesics before the start of naldemedine to clear predictors of diarrhea due to Naldemedine. Method: All data were retrospectively collected from the electronic medical record system. We investigated patients who initially administrated naldemedine at Nagasaki University Hospital from June 1 2017 to March 31 2019. Result: One hundred thirty-two patients were subject of investigation. The incidence of diarrhea was 25.0%. The result of the multivariate analysis showed that significant predictors of diarrhea were associated with the opioid analgesics usage period longer than 7 days before naldemedine initiation (odds ratio: 3.76, 95% confidence interval: 1.53-9.20, p=0.004). Discussion: When naldemedine was used for OIC, diarrhea may be avoided by using within 7 days after opioid analgesics.

OBJECTIVE: This study estimated the effects of weekend and off-hour childbirth and the size of perinatal medical care center on the incidence of cerebral palsy. METHODS: The cases were all children with severe cerebral palsy born in Japan from 2009 to 2012 whose data were stored at the Japan Obstetric Compensation System for Cerebral Palsy database, a nationally representative database. The inclusion criteria were the following: neonates born between January 2009 and December 2012 who had a birth weight of at least 2000 g and gestational age of at least 33 weeks and who had severe disability resulting from cerebral palsy independent of congenital causes or factors during the neonatal period or thereafter. Study participants were restricted to singletons and controls without report of death, scheduled cesarean section, or ambulance transportation. The controls were newborns, randomly selected by year and type of delivery (normal spontaneous delivery without cesarean section and emergency cesarean section) using a 1:10 case to control ratio sampled from the nationwide Japan Society of Obstetrics and Gynecology database. RESULTS: A total of 90 cerebral palsy cases and 900 controls having normal spontaneous delivery without cesarean section were selected, as were 92 cerebral palsy cases and 920 controls with emergent cesarean section. A significantly higher risk for cerebral palsy was found among cases that underwent emergent cesarean section on weekends (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.06-2.81) and during the night shift (OR 2.29, 95% CI 1.30-4.02). No significant risk was found among normal spontaneous deliveries on weekends (OR 1.63, 95% CI 0.97-2.73) or during the quasi-night shift (OR 1.26, 95% CI 0.70-2.27). Regional perinatal care centers showed significantly higher risk for cerebral palsy in both emergent cesarean section (OR 2.35, 95% CI 1.47-3.77) and normal spontaneous delivery (OR 2.92, 95% CI 1.76-4.84). CONCLUSION Labor on weekends, during the night shift, and at regional perinatal medical care centers was associated with significantly elevated risk for cerebral palsy in emergency cesarean section.
Case-Control Studies ; Cerebral Palsy ; epidemiology ; etiology ; Delivery, Obstetric ; statistics & numerical data ; Health Facilities ; statistics & numerical data ; Humans ; Incidence ; Infant, Newborn ; Japan ; epidemiology ; Parturition ; Perinatal Care ; statistics & numerical data ; Retrospective Studies ; Time Factors