BACKGROUND: By current estimates, it takes 17 years to adopt a new evidence-based practice (EBP) intervention. Nursing efforts to increase EBP adoption typically focus on education. But, there is a research gap in that there is a lack of evidence to support that education impacts the adoption of evidence-based practice. This study explored factors associated with adopting quantitative pupillometry (QP). METHODS: This longitudinal, retrospective study used registry data to calculate QP usage rates between 2015 and 2021. Events and interventions hypothesized to increase EBP adoption were identified through stakeholder interviews and literature search. Events were categorized as: conference presentations, publications, education, new study sites, QP adoption on other nursing units, equipment purchase, and policy changes. Scatterplots and Spearman's Rho were used to examine the relationship between time and usage rate of QP. Odds ratio analyses were conducted to explore the relationship between the selected event types and changes in usage rate from month-to-month. RESULTS: Using 74,428 QP observations from 3,976 patients, there was a significant positive relationship between usage rate of QP and time (r = .642, P < .0001). However, there was no statistically significant odds of any event-type (alone or in combination) impacting the rate of QP adoption. CONCLUSION Time was the only independent variable significantly associated with an increase in EBP adoption for this intervention. Common methods used to accelerate nursing adoption of EBP may have limited effect.