Darier disease is an autosomal dominant skin condition characterized histologically by acantholysis due to mutations in the ATP2A2 gene. This commonly presents in seborrheic distribution as greasy, yellow-brown keratotic papules. Presenting a case of a 14-year-old male, who experienced progressive red to brown scaly rashes which started on the face progressing to the trunk and inguinal areas in a seborrheic distribution with nail brittleness. Treatment included topical corticosteroids and retinoids, leading to gradual improvement. Management emphasizes the importance of avoiding triggers and highlighting the significance of early intervention and eventual multidisciplinary support.

Human ; Bacteria ; Male ; Adolescent: 13-18 Yrs Old ; Darier Disease

Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary cicatricial alopecia in women of African descent but has rarely been reported from other parts of the world. It is also rarely reported in the Philippines hence there is a need to investigate this condition. Distinguishing this from other scarring alopecia is important to be able to give the proper treatment and intervention. A 28-year-old Filipino male presented at an outpatient dermatology clinic in the Philippines with a two-years history of erythematous bump with bald spot on the vertex area of the scalp associated with 8/10 itch and 2-4/10 tenderness. He denied any burning or decrease in sensation on the affected area as well as previous history of bald spot or trauma to the scalp. He did not notice any similar lesion on other parts of the body. There is no family history of alopecia. There were no history of hair treatments or hair dye use, however admits to occasional application of hair gel and use of a cap. Clinical, trichoscopy, and histologic findings confirmed the diagnosis of CCCA. There are no clear guidelines that exist for the management of CCCA. However, early intervention reduces the chance of disease progression. The use of anti-inflammatory therapy is considered the first-line treatment such as topical steroids or intralesional triamcinolone acetonide.

Human ; Male ; Adult: 25-44 Yrs Old

Human ; Male ; Adult ; Epinephrine ; Fluorouracil ; Lidocaine ; Prospective Studies ; Warts