Objective To explore the efficacy and feasibility of suprapubic cystostomy combined with transurethral vapor resection of the prostate(TUVRP)for large benign prostatic hyperplasia(BPH).Method Twenty-eight cases with large BPH were treated with suprapubic cystostomy combined with TUVRP and the clinical data was analyzed retrospectively.Results After operation,all patients had normal urination,followed up for 6 months,the international prostatic symptom score was decreased from(24.2 ±4.8)scores to(9.8 ±2.6)scores,the maximal uroflow rate was increased from(6.2 ±2.1)ml/s to(14.8 ±2.9)ml/s,the residual urine was decreased from(108.0 ± 37.1)ml to(20.2 ± 7.6)ml,there was significant difference(P ＜ 0.05).Complications were found in 3 cases,2 cases were transurethral resection of prostate syndrome,I case was secondary bleeding.Conclusion Suprapubic cystostomy combined with TUVRP is a safe,less complication,effective and feasible method for large BPH with proficient skill.