1.A vision to remember
Eleonore B. Iguban ; Prospero Ma. C. Tuañ ; o ; Rolando Enrique D. Domingo ; Pearl M. Tamesis-Villalon
Philippine Journal of Ophthalmology 2011;36(2):92-95
On May 1911, the Department of Eye, Ear, Nose, and Throat (EENT) of the Philippine General Hospital (PGH) was established under the able leadership of Dr. Reinhart Remebe. As part of its commitment to pursue excellence and unconditional service, the graduates of what was then the Philippine Medical School (now the University of the Philippines College of Medicine (UPCM)) had to undergo a month of comprehensive training as an orientation to the department.
2.Comparative efficacy of smartphone imaging with 3D-printed adaptor versus fundus camera for diabetic retinopathy screening
Charlene V. Tablante ; Eleonore B. Iguban
Philippine Journal of Ophthalmology 2024;49(2):122-129
OBJECTIVE
To determine if dilated smartphone photography with a 3D-printed adaptor for a fundus lens can be an alternative screening tool for diabetic retinopathy.
METHODSThis was a single-center, prospective, comparative study of 102 eyes of patients with diabetes mellitus. DR screening was performed using binocular indirect ophthalmoscopy (BIO) as the reference standard, alongside two imaging modalities: a traditional fundus camera and a smartphone equipped with a 3D-printed adaptor. Coded images were evaluated by three masked retina specialists. Sensitivity, specificity, predictive values, and likelihood ratios were calculated for both imaging modalities.
RESULTSDR gradings of both imaging modalities were compared to BIO and showed very good agreement (κ 0.94-0.96 95% CI 0.93-0.99). Both have high levels of interobserver reliability (kappa value 0.88-0.92 95% CI 0.84-0.96) and intraobserver reliability (kappa value 0.85-1.00 95% CI 0.64-1.00). Smartphone and Visucam 500 images can detect presence of DR with a sensitivity of 93.9% (95% CI 83.1-98.7) and 91.8% (95% CI 80.4- 97.7); and a specificity of 90.6% (95% CI 79.3-96.9) and 92.5% (95% CI 81.8-97.9), respectively, as well as the presence of vision threatening DR with a sensitivity of 100% (95% CI 91.2-100) and specificity of 85.5% (95% CI 74.2-93.1). Image quality was similar between the two imaging modalities (P=1.00).
CONCLUSIONSmartphone-based imaging with an attached 3D-printed adaptor offers high sensitivity and reliability comparable to a traditional fundus camera, and can be used an alternative for DR screening.
Diabetic Retinopathy
3.The antimicrobial efficacy of multipurpose contact lens solutions on standard strains of common ocular pathogens
Eleonore B. Iguban ; Juan Pablo R. Nañ ; agas ; Roslyn F. De Mesa-Rodriguez
Philippine Journal of Ophthalmology 2013;38(1):35-42
Objective:
To compare the antimicrobial effects of locally available multipurpose contact lens solutions (MPS) on
the growth of standard strains of contact lens-related ocular pathogens and to establish the recommended duration
of exposure to these solutions to achieve maximal antimicrobial efficacy.
Methods:
This study, a single-blind controlled experiment, evaluated five locally available MPS in terms of their
antimicrobial efficacy towards common contact lens-related ocular pathogens, such as P. aeroginosa, S. aureus,
E. coli, F. solani, and C. albicans, using the stand alone criteria. Microbial viability counts were obtained at serial
durations: after 1 hour, 3 hours, 6 hours, and 12 hours of exposure.
Results:
MPS containing polyquaternium-1 and myristamidopropyl dimethylamine (MAPD) and polyhexamide
reduced the bacterial concentrations by 3 log and fungal concentrations by 1 log, enabling them to fulfill the stand
alone criteria for disinfecting solutions as mandated by ISO/CD 14729. This antimicrobial efficacy was most
evident at 6 hours of exposure to the challenge organisms. MPS containing polyquaternium-1 and MAPD also have
the broadest spectrum of effectivity against gram-negative and gram-positive bacteria, and C. albicans. All MPS
tested have poor microbial activity against F. solani.
Conclusion
Multipurpose contact lens solutions demonstrated variability in their antimicrobial activity. MPS with
broad spectrum efficacy and effectivity, such as those containing polyquaternum and MAPD, are preferred to
prevent contact lens-related ocular infections.
Contact Lenses