1.Pharmacological activities of a novel phthalic acid ester and iridoid glycoside isolated from the root bark of Anthocleista vogelii Planch
Anyanwu, G.O. ; Onyeneke, E.C. ; Okoli, B.J. ; Johannes, M.S. ; Sabi-ur-Rehman ; Iqbal, J. ; Ejaz, S.A. ; Zaib, S. ; Rauf, K. ; Nisar-ur-Rahman
Tropical Biomedicine 2019;36(1):35-43
In this study, a novel phthalic acid ester (1) and a known iridoid glycoside (2) were
isolated from the root bark of Anthocleista vogelii. The structures of the novel compound and
iridoid glycoside were elucidated on the basis of their chemical and spectral data (UV, FT-IR,
EI-MS, 1D and 2D NMR) and found to be phthalic acid ester, 4-ethyl-6-propyl-4,5,6,7-tetrahydro-
3H-2,8-benzodioxacycloundecine-1,9-dione (1) and sweroside (2). The compounds were
evaluated for their in vitro inhibitory activities against pancreatic lipase, α-amylase and α-
glucosidase, and in vivo laxative activity in rats. The metabolite phthalic acid ester (1)
exhibited moderate inhibitory activity against pancreatic lipase (IC50 = 24.43 ± 0.096 μg/mL)
and relatively good activity against α-glucosidase (IC50 = 10.28 ± 0.015 μg/mL). Sweroside (2)
displayed weak activity against α-glucosidase (IC50 = 40.28 ± 0.063 μg/mL) but significantly
(p<0.05) increased the feacal output of the treated animals compared to the normal and
sodium picosulfate controls.
Result Analysis
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