Introduction: Musculoskeletal disorders are the most common debilitating causes in workers and the main reason for medical leaves. Medial leave brings health, social, and economic consequences for individuals and society. The relationship between medical leaves due to pain and discomfort in different parts of the body and physical activity level at work, practice of sport, and leisure time in workers in cement industry in 2019 was examined. Methods: A descriptive-analytical study was conducted on 150 workers of a cement factory. The participants were selected randomly. Data gathering tools were demographics form, Nordic Musculoskeletal Questionnaire, and Baecke Physical Activity Questionnaire and the collected data was analyzed using SPSS (v.22). Results: The participants noted that the main painful areas over the past year were the waist, knee, ankle, and neck. There was a significant relationship between medical leave due to pain in the neck and overtime work. There was a significant relationship between the type of work activity and medical leave due to a pain in knee and ankle. Conclusion: The workers who used such medical leaves had a higher PAL at work. PAL at work increased the requests of medical leaves due to the pain in knee and waist. The PAL at sport practice decreased the rate of request for medical leave due to a pain in the Waist and Knee.