Introduction: Chronic kidney disease is a public health problem in the world which is increasing every year. Hemodialysis is one of the methods commonly used for patients with end-stage chronic kidney disease. However, hemodialysis does not cure the disease and requires long term therapy. So, the patient's decision whether to undergo hemodialysis, is crucial. Methods: This study is aimed to identify the factors associated with decision making in patients with end-stage chronic kidney disease undergoing hemodialysis in the Bahteramas General Hospital of Southeast Sulawesi Province, Indonesia. This study is a descriptive-analytic study using a cross-sectional design to observe the relationship between patients' decision making for hemodialysis. Results: A total of 34 patients with end-stage chronic kidney disease were chosen by accidental sampling technique. Analysis of the data was done by the Chi-Square test. The results of this study showed that age, level of knowledge, and family support have a significant relationship with the patient's decision for hemodialysis. The distance of home and economic status showed no relationship with the patient's decision to undergo hemodialysis. Conclusion: Based on the results of this study it can be concluded that age, level of knowledge and family support is related to the patient's decision to hemodialysis in the Bahteramas General Hospital of Southeast Sulawesi Province.