Objective To evaluate CT diagnosis and differential diagnosis of thoracic granulomatous diseases.Methods 13 cases of thoracic granulomatous diseases(tuberculoma 5,mycosis 3,sarcoidosis 2,Wegener's granuloma 2,eosinophilic granuloma 1) proved surgically-pathologically together with clinical and imaging data undergone analysis,especially put emphasis on CT features.Results ①Pulmonary granulomatous lesions commonly presented as nodules or masses,single or multiple,all the lesions had cavity,as well known pulmonary tuberculoma,pulmonary mycosis and Wegener's granuloma.②Cavity associated with mobile mass inside presented as air meniscus or air sing sign were the imaging characteristics of pulmonary aspergilloma.③Hilar and mediastinal lymphadenectasis always presented as bilaterally and symmetrically that was the typical sign of stage I sarcoidosis.④The multiple,multiplicity together with necrosis and cavity were the characteristics of wegener's granuloma.⑤Nodules and pneumtoceles were the major specific signs of pulmonary eosinophilic granuloma.Conclusion To analyse CT specific features and in combination with clinical data,it can improve the diagnostic accuracy of pulmonary granulomatous diseases.

Objective To study the efficacy and adverse reactions for renal transplant patients conversed from cyclospo-rine A to tacrolimus .Methods The follow-up data of renal transplant patients conversed from cyclosporine A to tacrolimus were collected .The clinical therapeutic outcomes including drug induced diseases (DIDs) and acute rejection (AR) induced by cyclosporine A were analyzed during the first year after conversion with SPSS 17 .0 software .Results The levels of Scr and BUN were significantly decreased during the first year after conversion for renal transplant patients with CScr and AR (P<0.05 or P<0 .01) .The levels of direct bilirubin (DB) and total bilirubin (TB) were also significantly lowed (P<0.05 or P<0 .01) during the first year for drug-induced liver injury (DILI) patients .The average level of ALT was significantly decreased in 12 months after conversion (P<0.05) .The complications of gingival overgrowth (GO) stopped with the medication replace-ment .However ,the fasting blood glucose (FBG) level increased significantly in 12 months after conversion (P<0.05) .Con-clusion For renal transplant patients suffered from AR or the serious DIDs induced by cyclosporine A ,conversion from cyclos-porine A to tacrolimus could be considered .However ,it should be aware of the high blood glucose or the new diabetes caused by tacrolimus .