1.Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report
Rahul KUMAR ; John Chen HSIANG ; Jessica TAN ; Prem Harichander THURAIRAJAH
Clinical and Molecular Hepatology 2019;25(3):326-330
No abstract available.
Drug-Induced Liver Injury
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Ribavirin
7.Primary study on hepatoprotective effect of curcuminoid in mice
Thanh Ngoc Vu ; Mai Thi Tuyet Vu
Journal of Medical Research 2007;47(2):22-28
Background: Curcuminoid in crocus has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities. Curcuminoid \ufffd?biofavonoid, a component of Cucuma longa L is attracting attention of researchers because of their effects and low toxicity. Objectives:To evaluate the hepatoprotective effect of curcuminoid on acute liver injury induced by carbon tetraclorid (CCl4 and paracetamol (PAR) in mice.) Subjects and method: Curcuminoid at doses of 60mg/kg and 120mg/kg were used in 8 consecutive days before hepatotoxins ( CCl4 0.5ml/kg in olive oil or PAR 400mg/kg) in mice.Results & Conclusion: Curcuminoid has hepatoprotective effect, expressed by reductions of serum levels of ALT, AST and liver histopathological injuries, in comparison with the control group ( which didn\u2019t use any drug). Curcuminoid at doses of 60mg/kg and 120mg/kg have hepatoprotective effect on acute liverinjury induced by carbon tetraclorid and paracetamol in mice. Curcuminoid at two different doses and silymarin at a dose 67mg/kg. The result showed that just low dose of curcuminoid (60mg/kg in mice) was enough to protect liver. It was just cheaper and safer than using high dose when using high dose the effect was not increase much.\r\n', u'\r\n', u'
Curcuma/ chemistry
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drug effects
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Drug-Induced Liver Injury
10.Drug-induced bile duct injury: progress and challenges.
Chinese Journal of Hepatology 2023;31(4):339-344
Drug-induced bile duct injury is a specific kind of drug-induced liver injury that has two main pathological types, namely ductopenia, or vanishing bile duct syndrome, and secondary sclerosing cholangitis. However, in recent years, the reports of new drugs that cause bile duct injury have been constantly increasing, and these drugs have different clinicopathological features and a novel pathogenesis. Therefore, this paper summarizes and analyzes the progress and challenges in the etiology, pathogenesis, diagnosis and treatment, and other aspects of drug-induced bile duct injury.
Humans
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Cholestasis/chemically induced*
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Cholangitis, Sclerosing/diagnosis*
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Chemical and Drug Induced Liver Injury/pathology*
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Bile Ducts/pathology*
Result Analysis
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